{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:28:49Z","timestamp":1786343329670,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371266"],"award-info":[{"award-number":["82371266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016698","name":"Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province","doi-asserted-by":"publisher","award":["82171252"],"award-info":[{"award-number":["82171252"]}],"id":[{"id":"10.13039\/100016698","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Science and Technology Natural Science Foundation","award":["No.25ZR1402042"],"award-info":[{"award-number":["No.25ZR1402042"]}]},{"name":"Clinical Research Project Supported by Huashan Hospital, Fudan University","award":["2023-YN008"],"award-info":[{"award-number":["2023-YN008"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder with different metabolic patterns in parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes, but their longitudinal changes are not well understood. To characterize longitudinal changes of glucose metabolism and network connectivity in MSA using\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG-PET for early diagnosis and disease progression tracking, we retrospectively analyzed 29 MSA patients (17 MSA-P, 12 MSA-C) and 28 healthy controls. Regional glucose uptake was assessed as standardized uptake value ratios (SUVR). We examined inter-regional connectivity via correlation analysis and modeled metabolic decline using nonlinear mixed-effects models. Clinical progression was measured using the Unified Multiple System Atrophy Rating Scale (UMSARS). MSA-P displayed progressive hypometabolism in the putamen, cerebellum, and frontal cortex, while MSA-C showed declines primarily in the cerebellum and frontal regions. Longitudinal modeling indicated a faster putaminal decline in MSA-P (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.015\u2009\u00b1\u20090.006) than in MSA-C (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u20090\u2009\u00b1\u20090.011), whereas cerebellar metabolism declined over time in both groups with overlapping slopes in MSA-P (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.022\u2009\u00b1\u20090.006) and MSA-C (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.022\u2009\u00b1\u20090.011). Regional metabolic reductions correlated with UMSARS progression (putamen in MSA-P:\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.59,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001; cerebellum in MSA-C:\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.62,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Significant connectivity disruptions were noted in frontal, basal ganglia, and cerebellar-parietal circuits. Longitudinal FDG-PET reveals distinct metabolic decline patterns in MSA subtypes\u2014putamen in MSA-P and cerebellum in MSA-C\u2014linked to clinical severity. These findings may inform clinical practice and trial design, supporting the use of FDG-PET for biological staging, monitoring disease progression, and potentially evaluating treatment responses.\n                  <\/jats:p>","DOI":"10.1177\/1877718x261455593","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:39:15Z","timestamp":1779975555000},"page":"992-1001","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral metabolic trajectories alterations in multiple system atrophy: A longitudinal FDG-PET study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-9791","authenticated-orcid":false,"given":"Yixin","family":"Zhao","sequence":"first","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamei","family":"Lin","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Zuo","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-395X","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Ge","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng-Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00058-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70327-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf117"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1984-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4243"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102416"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm328"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02645-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324823"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06493-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20255"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27945"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00456"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz189"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05325-z"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00786-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01701-x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.4643"},{"key":"e_1_3_3_23_2","article-title":"Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography","volume":"12","author":"Oh M","year":"2017","unstructured":"Oh M, Kim JS, Oh JS, et al. Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography. 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