{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:27:26Z","timestamp":1793950046313,"version":"4.8.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Burst deep brain stimulation (DBS) is a promising alternative to conventional deep brain stimulation (cDBS), incorporating paradigms such as theta burst stimulation (TBS), burst cycling (BC), and coordinated reset (CR). Findings from transcranial magnetic stimulation, spinal cord stimulation and focused ultrasound neuromodulation inspire its potential application in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review evaluates the evidence on the efficacy and safety of burst DBS in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted in PubMed, Embase, and Web of Science. Inclusion criteria encompassed peer-reviewed primary preclinical or clinical studies in English, reporting motor outcomes and burst stimulation parameters. Methodological quality was assessed using SYRCLE and a modified Newcastle-Ottawa Scale. Data extraction was performed systematically, and findings were synthesized narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>19 studies met inclusion criteria: nine preclinical and ten clinical studies. Eight focused on BC (three including safety), four examined TBS (two including safety), and seven addressed CR (one including safety). Burst DBS showed mostly similar acute efficacy to cDBS, with distinct post-stimulation effects. No major adverse events were reported. However, stimulation settings varied widely, with no consensus on optimal parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efficacy and safety of burst DBS appear to be comparable to cDBS, with potential benefits such as post-stimulation effects. However, the risk of bias, variability in stimulation settings, inconsistent terminology, and other methodological considerations limit the interpretation of previous research. Further randomized studies are crucial to better refine the stimulation parameters and establish standardized clinical protocols that can be used to compare burst DBS with cDBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1877718x261474705","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:07:22Z","timestamp":1785586042000},"page":"1438-1453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2403-4469","authenticated-orcid":false,"given":"Martijn","family":"Hendriks","sequence":"first","affiliation":[{"name":"Radboud University Medical Center"},{"name":"Neuromodulation &amp; Translational Neuroengineering Laboratory, Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1518-2482","authenticated-orcid":false,"given":"Matej","family":"Lokar","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-5056","authenticated-orcid":false,"given":"Hisse","family":"Arnts","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center"},{"name":"Neuromodulation &amp; Translational Neuroengineering Laboratory, Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-8691","authenticated-orcid":false,"given":"Rob MC","family":"Mestrom","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-3441","authenticated-orcid":false,"given":"Dejan","family":"Georgiev","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"},{"name":"Artificial Intelligence Laboratory, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-1849","authenticated-orcid":false,"given":"R Saman","family":"Vinke","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center"},{"name":"Neuromodulation &amp; Translational Neuroengineering Laboratory, Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey ER","year":"2018","unstructured":"Dorsey ER, Sherer T, Okun MS, et al. 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