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Neuroimaging, particularly positron emission tomography (PET) with [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorodeoxyglucose (FDG), plays a crucial role by offering in vivo assessments of brain activity through glucose metabolism, a marker of neuronal function. FDG-PET has demonstrated consistent metabolic abnormalities in PD, even in early or ambiguous stages, supporting its potential as both a diagnostic and mechanistic tool. Recent advancements in analytical methods, including regional univariate, pattern-based multivariate, network connectivity, and machine learning approaches, have allowed for more detailed exploration of PD-related brain dysfunction across multiple spatial, temporal, and organizational scales. This review provides an overview of the various FDG-PET analysis methods, discussing their principles, strengths, and limitations, with an emphasis on their utility for applications in PD, including both diagnostic applications and insights into underlying neural mechanisms.\n                  <\/jats:p>","DOI":"10.1177\/1877718x261492275","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:54:37Z","timestamp":1790409277000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A review of FDG-PET biomarker analysis methods in Parkinson's disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6972-8233","authenticated-orcid":false,"given":"Erik","family":"Reimers","sequence":"first","affiliation":[{"name":"University of British Columbia"},{"name":"Djavad Mowafaghian Centre for Brain Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6258-8450","authenticated-orcid":false,"given":"Connor","family":"Bevington","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health"},{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-7246","authenticated-orcid":false,"given":"A. 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