{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:24:55Z","timestamp":1783416295943,"version":"3.54.6"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Disrupted 24-h sleep-wake and rest-activity cycles are known common features in Huntington's disease (HD) patients; however, critical periods during the 24-h cycle have been less studied.\n                    <jats:bold>Objective:<\/jats:bold>\n                    To analyze the differences between early-mid stage HD patients and healthy controls (HC) in sleep patterns and 24-h motor activity by using actigraphic monitoring.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty HD patients (13 females; mean age\u2009\u00b1\u2009SD 56.45\u2009\u00b1\u200916.94) at early-mid stage of the disease and 20 HC were actigraphically monitored for a week. We applied the Functional Linear Modeling (FLM) to analyze motor activity from the actigraphic data. We analyzed parameters regarding both the time spent in bed and out of bed; get-up time (GUT); time in bed (TIB); midpoint of sleep (MS); sleep motor activity (SMA); sleep onset latency (SOL); total sleep time (TST); wake after sleep onset (WASO); sleep efficiency (SE); number and duration of awakenings (AWK); diurnal motor activity (DMA) and diurnal total sleep time (DTST).\n                    <jats:bold>Results:<\/jats:bold>\n                    Ten patients were in Stage I, 6 in Stage II and 4 in Stage III. HD patients presented lower SE and higher TIB, SOL, WASO, AWK and AWK\u2009&gt;\u20095\u2005min in comparison to HC. Moreover, higher motor activity was observed in patients with HD, in particular between 2:15 and 4:00 am, from around 40\u2005min prior to bedtime until 20\u2005min after bedtime, and from around 20\u2005min prior to get-up time until 50\u2005min after get-up time.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Actigraphy documented a specific 24-h motor pattern in HD, potentially constituting a disease signature.\n                  <\/jats:p>","DOI":"10.1177\/18796397241287227","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:49:17Z","timestamp":1734670157000},"page":"501-509","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep-wake cycle and 24-h motor activity in early-mid Huntington's disease patients: An actigraphy-based study"],"prefix":"10.1177","volume":"13","author":[{"given":"Cesa","family":"Scaglione","sequence":"first","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Unit Cesena (Forl\u00ec), Bufalini Hospital, AUSL Romagna, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Tonetti","sequence":"additional","affiliation":[{"name":"Department of Psychology \u201cRenzo Canestrari\u201d, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-8083","authenticated-orcid":false,"given":"Sara","family":"Giovagnoli","sequence":"additional","affiliation":[{"name":"Department of Psychology \u201cRenzo Canestrari\u201d, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Barletta","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"},{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Calandra-Buonaura","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"},{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-603X","authenticated-orcid":false,"given":"Pietro","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Di Laudo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Psychology \u201cRenzo Canestrari\u201d, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Provini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"},{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.4.482"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24495"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-230576"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.02.009"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3842-04.2005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0709-z"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbscr.2018.07.001"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1740-3391-9-11"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.05.002"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.05.022"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/clockssleep4030032"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12040424"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12161"},{"key":"e_1_3_5_15_2","first-page":"467","volume-title":"Sleep \u201884","author":"Zomer J","year":"1985","unstructured":"Zomer J, Peder R, Rubin AH, et al. Mini Sleep Questionnaire for screening large populations for EDS complaints. In: Koella WP, Ruther E, Schulz H (eds) Sleep \u201884. Stuttgart: Gustav Fisher, 1985, pp.467\u2013470."},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.5.461"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101762"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.206"},{"key":"e_1_3_5_19_2","first-page":"85","article-title":"The neuroanatomy of sleep. Considerations on the role of the thalamus in sleep and a proposal for a caudorostral organization","volume":"8","author":"Lugaresi E","year":"2004","unstructured":"Lugaresi E, Provini F, Montagna P. The neuroanatomy of sleep. Considerations on the role of the thalamus in sleep and a proposal for a caudorostral organization. Eur J Anat 2004; 8: 85\u201393.","journal-title":"Eur J Anat"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.08.008"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.12.021"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2016.01.009"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq047"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.001"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110406"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.09.013"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.10.002"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314781"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-378610-4.00098-X"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26003"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12255"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.12.011"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-230574"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.07.013"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2009.07.004"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91505-2"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18796397241287227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18796397241287227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18796397241287227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:50:41Z","timestamp":1783414241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18796397241287227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/18796397241287227"],"URL":"https:\/\/doi.org\/10.1177\/18796397241287227","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}