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Recent observations suggest that disturbances in social cognition may feature prominently in HD, potentially contributing to behavioral challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the onset and neural mechanisms underlying social cognition disturbances in HD, which are not yet well understood despite increasing recognition of these symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study compared 20 individuals in the early stages of HD with 20 healthy controls across a range of cognitive tests, in-depth social cognition assessments, and structural MRI evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The findings revealed alterations in various aspects of social cognition, particularly cognitive and affective Theory of Mind, in the early HD group. Some of these alterations correlated with the neurodegeneration of the striatum (caudate), suggesting that social cognition deficits may serve as early indicators of disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research underscores the importance of integrating social cognition evaluations into the clinical assessment of HD and hints at a complex interplay between these deficits and the broader neuropsychological impact of the disease. The results thus advocate for a more holistic approach to understanding and managing HD, considering the potential interdependencies between social cognition and other cognitive functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397241291730","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:49:17Z","timestamp":1734670157000},"page":"467-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Social cognition profile in early Huntington disease: Insight from neuropsychological assessment and structural neuroimaging"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-8182","authenticated-orcid":false,"given":"Marie","family":"Caillaud","sequence":"first","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, [CHU Angers], LPPL, SFR CONFLUENCES, Angers, France"},{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"},{"name":"Department of Psychology, University of Texas at Austin, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Laisney","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-0951","authenticated-orcid":false,"given":"Alexandre","family":"Bejanin","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"},{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-6749","authenticated-orcid":false,"given":"Harmony","family":"Duclos","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Scherer-Gagou","sequence":"additional","affiliation":[{"name":"Univ Angers, [CHU Angers], Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Prundean","sequence":"additional","affiliation":[{"name":"Univ Angers, [CHU Angers], Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bonneau","sequence":"additional","affiliation":[{"name":"Univ Angers, [CHU Angers], Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-8686","authenticated-orcid":false,"given":"Francis","family":"Eustache","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Verny","sequence":"additional","affiliation":[{"name":"Univ Angers, [CHU Angers], Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Desgranges","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Allain","sequence":"additional","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, [CHU Angers], LPPL, SFR CONFLUENCES, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1139\/jpn.0603"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_3_5_6_2","first-page":"62","article-title":"Neuropsychological and neuropsychiatric aspects of Huntington\u2019s disease","volume":"45","author":"Craufurd D","year":"2002","unstructured":"Craufurd D, Snowden J. 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