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To evaluate NfL's utility in HDL2, a comparative analysis among HDL2 (n\u2009=\u200912), HD (n\u2009=\u20099), and unaffected controls (n\u2009=\u20099) was conducted. Employing a cross-sectional design, NfL levels were assessed in blood plasma. Concentrations were notably elevated in both HD and HDL2 groups compared to controls. HD patients displayed higher NfL levels than HDL2, possibly reflecting disease duration differences. NfL effectively distinguished HDL2 from controls, highlighting its promise as a possible biomarker in HDL2 research.<\/jats:p>","DOI":"10.1177\/18796397241300141","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T01:48:50Z","timestamp":1732758530000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-6424","authenticated-orcid":false,"given":"David G","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK"},{"name":"Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of 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