{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:08:53Z","timestamp":1788368933890,"version":"build-2803163510"},"reference-count":150,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Huntington's disease (HD) is a hereditary neurodegenerative disease characterized by a combination of motor, cognitive, and mental health issues, with depression being the most common. Despite its importance, the relationship between depression and disease progression is still debatable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective of this study was to examine the frequency of depression across different disease stages in individuals with HD. We also explored the associations between depression and other HD-related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review comprehensively searched MEDLINE, APA PsycINFO, and Embase databases for studies on depression in individuals with HD. Pooled depression frequencies were calculated for premanifest and manifest HD. Depression was analyzed based on HD functional stages and diagnostic tools, alongside reviewing its association with various HD factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We assessed 6523 records and included 104 studies. Our meta-analyses revealed that the overall frequency of depression was higher in manifest HD compared to premanifest HD (0.38 vs. 0.23). However, the progression of depression did not follow a consistent pattern, with peaks occurring in earlier rather than later stages. Additionally, the frequency of depression was lower in studies using diagnostic criteria compared to those using clinical scales (0.25 vs. 0.42).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings showed that the rate of depression is high in HD and varies depending on the disease stage and the criteria used. This emphasizes the necessity for tailored and unified diagnostic criteria for depression in HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397241301774","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T03:33:47Z","timestamp":1733369627000},"page":"43-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Frequency of depression in Huntington's disease: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-0567","authenticated-orcid":false,"given":"Shayan Abdollah","family":"Zadegan","sequence":"first","affiliation":[{"name":"Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at the University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9931-1015","authenticated-orcid":false,"given":"Frank","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at the University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7888-7571","authenticated-orcid":false,"given":"Jung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-8082","authenticated-orcid":false,"given":"Natalia Pessoa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at the University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Furr Stimming","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at the University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-5422","authenticated-orcid":false,"given":"Antonio L","family":"Teixeira","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1039856218791036"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2954"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7060067"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14121551"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.20220033"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104958"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000301"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020318"},{"key":"e_1_3_5_10_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372: n71.","journal-title":"BMJ"},{"key":"e_1_3_5_11_2","unstructured":"Zadegan SA Park JW Ramirez F et al. The frequency and interconnections of depression in Huntington\u2019s disease: A systematic review and meta-analysis. PROSPERO 2023 CRD42023495322. https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023495322 (2023 accessed 1 March 2024)."},{"key":"e_1_3_5_12_2","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2023. https:\/\/www.R-project.org\/."},{"key":"e_1_3_5_13_2","volume-title":"RStudio: Integrated development environment for R","author":"Posit team","unstructured":"Posit team. RStudio: Integrated development environment for R. Boston, MA: Posit Software, PBC, 2023. https:\/\/www.posit.co\/."},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01381-z"},{"key":"e_1_3_5_16_2","unstructured":"Higgins J Thomas J Chandler J et al. Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021) http:\/\/www.training.cochrane.org\/handbook (2021 accessed 18 December 2023)."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320071018"},{"key":"e_1_3_5_18_2","first-page":"199","article-title":"Plasma testosterone, dehydroepiandrosterone sulfate, and cortisol in female patients with Huntington\u2019s disease","volume":"28","author":"Markianos M","year":"2007","unstructured":"Markianos M, Panas M, Kalfakis N, et al. Plasma testosterone, dehydroepiandrosterone sulfate, and cortisol in female patients with Huntington\u2019s disease. Neuro Endocrinol Lett 2007; 28: 199\u2013203.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.10.020"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13147"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00257-8"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.21070191"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2023.106002"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.103309"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.10.3.314"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.02.008"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27395"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2009.21.3.266"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.3.310"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0029218"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200091"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2010.22.3.287"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.10.002"},{"key":"e_1_3_5_34_2","first-page":"1","article-title":"A clinico-genetic study of psychiatric disorder in Huntington\u2019s chorea","volume":"23","author":"Watt DC","year":"1993","unstructured":"Watt DC, Seller A. A clinico-genetic study of psychiatric disorder in Huntington\u2019s chorea. Psychol Med 1993; Suppl 23: 1\u201346.","journal-title":"Psychol Med"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.09.012"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.16020025"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n1116"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-190365"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.10.016"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2018.02.030"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01671-x"},{"key":"e_1_3_5_42_2","first-page":"219","article-title":"Behavioral changes in Huntington disease","volume":"14","author":"Craufurd D","year":"2001","unstructured":"Craufurd D, Thompson JC, Snowden JS. Behavioral changes in Huntington disease. Neuropsychiatry Neuropsychol Behav Neurol 2001; 14: 219\u2013226.","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.01.010"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700047966"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.022756"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22837"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100412"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100067"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23136"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1306"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.6.728"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9450.1991.tb00877.x"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.4274\/tnd.2020.87533"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061676"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05787-x"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181da50d7"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.5.1305"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181da852a"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-160206"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720000094"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.02.009"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.03.021"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091523"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.04.030"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11982-x"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.14030051"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010206"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3258"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000793"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(02)00054-7"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.11.003"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101965"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28638"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-180291"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0498-4"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000134"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.026"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327754"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10929-4"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000286"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617722000364"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20739"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.10.031"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.001"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17070144"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000199"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.536"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1755-6"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020174"},{"key":"e_1_3_5_90_2","first-page":"93","article-title":"Understanding the relationship between perseveration, comorbid behavioral symptoms, motor decline, functional decline, and self-report accuracy in Huntington disease can help inform clinical practice","volume":"36","author":"Liu AM","year":"2023","unstructured":"Liu AM, Koppel E, Anderson KE. Understanding the relationship between perseveration, comorbid behavioral symptoms, motor decline, functional decline, and self-report accuracy in Huntington disease can help inform clinical practice. Cogn Behav Neurol 2023; 36: 93\u201399.","journal-title":"Cogn Behav Neurol"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-140133"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200613"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac278"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-150164"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2151"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617719000067"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.13.3.342"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000106004.67587.57"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2011.00563.x"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.17.4.496"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23337"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1159\/000480701"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12917"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13857"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.4.jnp434"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.4.jnp399"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.11.020"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171300247X"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200434"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.14.1.37"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11030057"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.01.002"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200446"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343210"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307343"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.074"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.05.006"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2016.1214555"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_3_5_120_2","volume-title":"Manual for the Beck Depression Inventory-II","author":"Beck AT","year":"1996","unstructured":"Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation, 1996."},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.028"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_3_5_126_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-140115"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00120-X"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200397"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.231"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200410"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.106969"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14188"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2013.03.012"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.07.001"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713001276"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.3928\/00989134-20151015-03"},{"key":"e_1_3_5_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.06.008"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1980-5764-2016dn1004002"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181cb87d6"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.01.006"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.026"},{"key":"e_1_3_5_144_2","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2019.0171"},{"key":"e_1_3_5_145_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.3\/dnutt"},{"key":"e_1_3_5_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.04.014"},{"key":"e_1_3_5_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.03.009"},{"key":"e_1_3_5_148_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6319826"},{"key":"e_1_3_5_149_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17080173"},{"key":"e_1_3_5_150_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200418"},{"key":"e_1_3_5_151_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.20230120"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18796397241301774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18796397241301774","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18796397241301774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:31Z","timestamp":1777452991000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18796397241301774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":150,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/18796397241301774"],"URL":"https:\/\/doi.org\/10.1177\/18796397241301774","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]}}}