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In this narrative review and case report, we first review the extant literature on applications of ACT to patients with a variety of mental and physical health challenges, including neurodegenerative disorders, and their caregivers. We then discuss applications of ACT to Huntington's disease (HD). We provide a case report of a 52-year-old man living with HD who, accompanied by his caregiver, received a virtually-delivered 6-session ACT intervention. We measured the patient's self-reported symptoms of depression (PHQ-9) and anxiety (GAD-7) as well as his health-related quality of life (HDQoL) and level of cognitive fusion (i.e., being attached to his thoughts; CFQ-13) at baseline and following the intervention. At follow-up, the patient had a clinically significant reduction in depressive symptoms (from moderate to mild symptomatology) and cognitive fusion. Further, the patient had improvements in quality of life across the domains of physical functioning, mood, and worries. The promising outcomes of this case, as well as extant literature on the effectiveness of ACT in supporting individuals with similar neurodegenerative disorders, suggests that ACT may hold promise as a scalable and impactful intervention for individuals living with HD and their caregivers. We conclude with a call for further study of ACT with this population to build a more robust evidence base that can be used to benefit individuals living with HD and their caregivers.<\/jats:p>","DOI":"10.1177\/18796397251315162","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:36:09Z","timestamp":1738157769000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Acceptance and commitment therapy with Huntington's disease: A narrative review and case report of a caregiver-assisted intervention"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-5867","authenticated-orcid":false,"given":"Simone H","family":"Schriger","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6363-1714","authenticated-orcid":false,"given":"Chelsi N","family":"Nurse","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-8009","authenticated-orcid":false,"given":"C Virginia","family":"O\u2019Hayer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2016.11.006"},{"key":"e_1_3_5_3_2","volume-title":"Acceptance and commitment therapy: the process and practice of mindful change","author":"Hayes SC","year":"2011","unstructured":"Hayes SC, Strosahl KD, Wilson KG. 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