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Additionally, research on Huntington's disease characteristics in each nation was utilized to give a general picture of the disease's status in those nations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled point prevalence estimation of the prevalence studies was 8.64 per 100,000 (95% CI, \u22120.04\u201317.33; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009100%). Among 14 cohort and cross-sectional studies on individuals with Huntington's disease in the MENASA region, 5.61% of the patients had juvenile-onset Huntington's disease, and 2.3% had late-onset Huntington's disease. In addition, 68.58%, 17.82%, and 45.17% of the individuals were reported with motor symptoms at the onset, abnormal cognitive assessment scores, and degrees of psychological disturbance, respectively. The mean age at onset was 44.85 years, and the mean number of pathologic CAG repeats was 45.46.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Notable differences in the frequency of symptoms of onset and pooled prevalence of HD in the MENASA region probably address a serious lack of sufficient information. The results would help clinicians and governments develop public health strategies, and further research could be conducted on these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397251356620","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T03:06:28Z","timestamp":1751511988000},"page":"319-330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology and clinical features of Huntington's disease in MENASA region: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"14","author":[{"given":"Mehri","family":"Salari","sequence":"first","affiliation":[{"name":"Men's health and reproductive health research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-3175","authenticated-orcid":false,"given":"Kamran","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-7063","authenticated-orcid":false,"given":"Fatemeh","family":"Hojjati pour","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-0763","authenticated-orcid":false,"given":"Mercedeh","family":"Sepehrnia","sequence":"additional","affiliation":[{"name":"Shohada Tajrish Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Etemadifar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"A clinical and genetic profile of 17 patients with Huntington\u2019s disease seen in Southern India","volume":"26","author":"Jhavar KR","year":"2011","unstructured":"Jhavar KR, Pal PK, Nagaraj MS, et al. 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