{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:45Z","timestamp":1787841405911,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016374","name":"Cures Within Reach","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Huntington's disease (HD) is a neurodegenerative disorder caused characterized by motor, cognitive, and psychiatric\/behavioral impairments. Among these symptoms, irritability is particularly burdensome due to its frequency and significant impact on the daily lives of both patients and caregivers. Currently, no FDA-approved medication specifically targets this symptom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the efficacy of dextromethorphan\/quinidine (DM\/Q) 20\/10\u2005mg (NUEDEXTA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) in managing irritability in HD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Double-blind, placebo-controlled, randomized, crossover clinical trial. Participants underwent a 13-week study: six weeks of DM\/Q treatment, one-week washout, and six weeks of placebo. The DM\/Q 20\/10\u2005mg regimen started with a once-daily dose, increased to twice daily after the first week, and tapered back to once daily in the sixth week. Participants were evaluated during three in-person visits: at baseline and at the end of each treatment phase. Assessments included motor and cognitive exams, the Irritability Scale, and the Problem Behavior Assessment\u2013short version (PBA-s) (ClinicalTrials.gov NCT03854019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty participants were enrolled, with 18 completing the study (mean age = 43.94\u2009\u00b1\u200910.70 years, 11 females and 7 males). Both DM\/Q and placebo reduced mean Irritability Scale scores (32% and 27.5%, respectively) and the irritability subscale of the PBA-s (42% and 33%, respectively), with no statistically significant differences between groups. Additionally, DM\/Q showed no significant advantage over placebo in motor, behavioral, or cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DM\/Q did not demonstrate significant benefits in managing irritability compared to placebo. Further research with larger sample sizes and alternative therapeutic strategies is needed to effectively address this symptom in HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397251411112","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:56:56Z","timestamp":1767808616000},"page":"332-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the efficacy of dextromethorphan\/quinidine in treating irritability in Huntington's disease"],"prefix":"10.1177","volume":"15","author":[{"given":"Shayan A","family":"Zadegan","sequence":"first","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Calderon","sequence":"additional","affiliation":[{"name":"The University of Texas M.D. Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Karagas","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Patino","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Dongarwar","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Duncan","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L","family":"Teixeira","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-8082","authenticated-orcid":false,"given":"Natalia P","family":"Rocha","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Furr Stimming","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)"},{"name":"Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801893-4.00006-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200397"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-019-00237-x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.993357"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-140127"},{"key":"e_1_3_3_7_2","article-title":"An international survey-based algorithm for the pharmacologic treatment of irritability in Huntington\u2019s disease","volume":"3","author":"Groves M","unstructured":"Groves M, van Duijn E, Anderson K, et al. 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