{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:27:30Z","timestamp":1787300850864,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Balance impairments in Huntington's Disease (HD) are common but difficult to treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate the potential effects and feasibility of multimodal physiotherapy balance intervention in HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this prospective, double-blind, parallel group randomized clinical trial (phase 1pilot study), we screened 56 persons with genetically confirmed HD; 36 were assigned randomly into three groups: 1) multimodal physiotherapy balance intervention supported by rhythmical auditory stimuli (RAS-supported,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912); (2) multimodal physiotherapy balance intervention without rhythmical auditory stimuli (Regular,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912); and (3) control intervention (educational program,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912). Interventions were delivered for 2-months, at a low dose, 1 session\/week. The primary outcome was the Mini-BESTest scored directly after the intervention. All outcomes were assessed at three time-points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Directly post-intervention, both the RAS-supported group and the Regular group improved significantly on the Mini-BESTest score compared to the Control group (RAS-supported 4.2 (95% Confidence Interval(CI) 3.1; 5.2),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001; Regular 2.7 (CI 1.7; 3.6),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001. These improvements were retained at 6-month follow-up only for the RAS-supported group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings motivate future studies to further explore multimodal physiotherapy interventions to improve balance in HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397261468393","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:19:00Z","timestamp":1787077140000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodal balance training with rhythmical auditory cueing in Huntington's disease: A pilot randomized controlled trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-4141","authenticated-orcid":false,"given":"Tamine TC","family":"Capato","sequence":"first","affiliation":[{"name":"Donders Institute for Brain"},{"name":"Department of Neurology, Movement Disorders Clinic, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorik","family":"Nonnekes","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain"},{"name":"Radboud University Medical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordache","family":"Ramjith","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egberto R","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Movement Disorders Clinic, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-0747","authenticated-orcid":false,"given":"Joanna","family":"IntHout","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R","family":"Bloem","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28855"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008887"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.06.023"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-220532"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-220549"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.11.86"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100438"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070346"},{"key":"e_1_3_3_11_2","first-page":"189","article-title":"Effectiveness of intensive neurorehabilitation in patients with Huntington\u2019s disease","volume":"49","author":"Ciancarelli I","year":"2013","unstructured":"Ciancarelli I, Tozzi Ciancarelli MG, Carolei A. 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