{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:09:09Z","timestamp":1785161349697,"version":"3.55.0"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2017\/25\/N\/NZ2\/00812"],"award-info":[{"award-number":["2017\/25\/N\/NZ2\/00812"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/37\/B\/NZ2\/01050"],"award-info":[{"award-number":["2020\/37\/B\/NZ2\/01050"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent reports indicated that 4\u2032,5,7-trihydroxyisoflavone (genistein) can improve biochemical disorders and correct behavioral disturbances in cellular and animal models of Huntington's disease (HD), acting thorough stimulation of autophagy-dependent degradation of mutant huntingtin aggregates. Effects in the mouse HD model was tested previously only after appearance of symptoms of HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this work was to assess the efficacy of genistein in preventing the appearance of symptoms in the R6\/1 mouse model of HD, using both males and females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A battery of behavioral tests (Rota-rod, elevated-plus maze, Morris water maze, monitoring of movements in actometer) was used, and selected biochemical and hematological parameters were determined in control (wild-type) and R6\/1 (HD) mice (males and females) treated with either orally-administered genistein at 150 mg\/kg\/day or water (control). The treatment was initiated at 7\n                      <jats:sup>th<\/jats:sup>\n                      week of life (while the first symptoms appear at 14\u201316 week in this HD model), and was continued until 30\n                      <jats:sup>th<\/jats:sup>\n                      week.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Administration of genistein resulted in extension of life span and prevention of appearance of HD symptoms in R6\/1 mice. The immunological and biochemical parameters were comparable between wild-type and R6\/1 mice treated with genistein, whereas the untreated HD animals revealed significant differences relative to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genistein appeared to be effective in preventing the appearance of severe symptoms of HD in the mouse R6\/1 model, indicating that this compound might be considered as a potential anti-HD drug.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18796397261472379","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:40:46Z","timestamp":1784983246000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of appearance of severe Huntington's disease symptoms in the R6\/1 mouse model by early administration of 4\u2032,5,7-trihydroxyisoflavone"],"prefix":"10.1177","author":[{"given":"Lidia","family":"Gaffke","sequence":"first","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estera","family":"Rintz","sequence":"additional","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Podlacha","sequence":"additional","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"My\u015bli\u0144ska","sequence":"additional","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-7466","authenticated-orcid":false,"given":"Grzegorz","family":"W\u0119grzyn","sequence":"additional","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Pierzynowska","sequence":"additional","affiliation":[{"name":"University of Gda\u0144sk"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2020.100056"},{"key":"e_1_3_3_3_2","article-title":"Overview of Huntington\u2019s disease and emerging treatment strategies: a narrative review","volume":"17","author":"Vega AJ","year":"2025","unstructured":"Vega AJ, Hernandez GV, O'Malley PA, et al. 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