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Under nasal esketamine treatment his mood improved dramatically after three treatment days. Beck Depression Inventory (BDI) score dropped from 29 to 5. In a three-month follow-up investigation depression worsened again (BDI score: 20). To our knowledge, this is the first reported case of esketamine use in HD, suggesting that esketamine may be a treatment option for psychiatric symptoms in HD, particularly treatment-resistant depression.<\/jats:p>","DOI":"10.1177\/18796397261489245","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:38:33Z","timestamp":1789655913000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Esketamine for treatment of depression in Huntington's disease: A case report"],"prefix":"10.1177","author":[{"given":"Carsten","family":"Saft","sequence":"first","affiliation":[{"name":"St Josef Hospital, Ruhr-University Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2157-9419","authenticated-orcid":false,"given":"Julia","family":"Jessen","sequence":"additional","affiliation":[{"name":"St Josef Hospital, Ruhr-University Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-9291","authenticated-orcid":false,"given":"David","family":"Kiefner","sequence":"additional","affiliation":[{"name":"LWL University Hospital, Ruhr University Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Juckel","sequence":"additional","affiliation":[{"name":"LWL University Hospital, Ruhr University Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14121551"},{"key":"e_1_3_3_3_2","first-page":"192","article-title":"Longitudinal personality changes among presymptomatic Huntington disease gene carriers","volume":"15","author":"Kirkwood SC","year":"2002","unstructured":"Kirkwood SC, Siemers E, Viken R, et al. 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