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Vesicular trafficking is a fundamental way to target proteins to their functional sites and thus essential for the maintenance of cellular homeostasis. HTT associates with vesicles and interacts with molecular motor proteins driving vesicle movement along cytoskeletons and with the molecular machines orchestrating vesicle formation, tethering and fusion. Rab proteins play key roles in each of the four major steps in vesicular trafficking. Here we provide an overview of Rab proteins perturbed in HD, how their disturbance contributes to disease progression, and ways to target them for therapy in Huntington's disease (HD).<\/jats:p>","DOI":"10.1177\/18796397261490952","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:05:57Z","timestamp":1790309157000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Defective membrane dynamics in Huntington's disease: A role of Rab11 dysfunction"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-5995","authenticated-orcid":false,"given":"An","family":"Wu","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School"},{"name":"Department of Neurosurgery, Affiliated Quzhou Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Kecheng District, Quzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-3432","authenticated-orcid":false,"given":"Xueyi","family":"Li","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-025-01159-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90346-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.8.1365"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90345-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-104"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.6.2703"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0053-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.02.018"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202200158"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90518-4"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-10-0737"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15453"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601617103"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2728"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/35052055"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02147-X"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04397"},{"key":"e_1_3_3_20_2","first-page":"971","article-title":"The huntington\u2019s disease collaborative research group","volume":"72","author":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","year":"1993","unstructured":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. 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