{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:51:49Z","timestamp":1777877509302,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"crossref","award":["Grant No. SHDC12020105 to Zhaoyan Wang"],"award-info":[{"award-number":["Grant No. SHDC12020105 to Zhaoyan Wang"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head & Neck Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Importance<\/jats:title>\n At present, there is no consensus on the concentration of epinephrine\/physiological saline for subcutaneous injection into external auditory canal (EAC) under general anesthesia in otoendoscopic surgery. A randomized controlled trial (RCT) research is needed to provide reference, as this concentration can provide satisfactory surgical field clarity while maintaining patients\u2019 hemodynamic stability.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n Comparison of the effect of subcutaneous injection of different concentrations of epinephrine\/physiological saline into EAC under general anesthesia in otoendoscopic surgery on surgical field clarity and hemodynamics.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This double-blind, RCT study was about the effect of topical epinephrine injection in otoendoscopic surgery.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n This study was conducted at a single institution.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n This study included 168 patients conformed to the inclusion criteria.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Patients were randomized to receive different concentrations of epinephrine\/physiological saline injection (1:5000, 1:10,000, 1:20,000, or 1:40,000) into the junction of bone and cartilage at posterior wall of EAC during surgery.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Surgical field clarity was assessed with surgical field clarity grading scale and tympanic membrane flap flipping time. Hemodynamic changes were monitored by clinical parameters of blood pressure, heart rate, and ST segment of ECG.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There were no statistically-significant differences in surgical field clarity grade ( P\u2009=\u2009.577) and tympanic membrane flap flipping time ( P\u2009=\u2009.490) among 4 concentration groups. Epinephrine injection did cause an increase in hemodynamic parameters when compared with baseline ( P\u2009<\u2009.05). Compared with the relatively-lower concentration groups (1:20,000 and 1:40,000), the relatively-higher concentration groups (1:5000 and 1:10,000) had more significant and long-lasting effect until 30\u2009minutes after injection.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and relevance<\/jats:title>\n Four concentration groups of topical epinephrine injection in otoendoscopic surgery have the same effect on surgical field clarity. For the stability of patients\u2019 hemodynamics, we would prefer to recommend the use of concentrations with minimal impact on hemodynamics, ranging from 1:20,000 to 1:40,000.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n Clinical Trial Registry-China: ChiCTRI1800016647.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/19160216241288811","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T14:25:50Z","timestamp":1729175150000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Different Concentrations of Epinephrine in Otoendoscopic Surgery on Surgical Field Clarity: A Double-Blind, Randomized Study"],"prefix":"10.1177","volume":"53","author":[{"given":"Wenying","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinya","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-0920","authenticated-orcid":false,"given":"Zhaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai, 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