{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:52:05Z","timestamp":1777877525964,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The clinical significance of oncocytes in thyroid aspirate is uncertain, leading to inconsistent and possible over-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the predictive significance of clinico-radiological parameters and cytologic diagnosis on the risks of malignancy (ROM) and neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Data of thyroid aspirates with the presence of oncocytes were reviewed for outcomes and clinical-radiological-pathological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three regional institutes performing thyroid surgery and investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>From a population base of 1.3\u2009million across a 9-year period, totaling 371 aspirates with oncocytes with an 85.0-month average follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Fine-needle aspiration of thyroid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On clinical follow-up, the ROM for Bethesda categories C1-C6 was 15.4%\/2.7%\/9.2%\/6.9%\/37.5%\/100%, while the risk of neoplasm (considering thyroidectomy follow-up) was 45.5%\/23.8%\/56.3%\/61.9%\/50%\/100%, including 52 oncocytic follicular lesions (4 carcinomas and 48 adenomas) and 26 other carcinomas\/malignancies. C5+ diagnoses were associated with malignancy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003), and C3+ was associated with neoplasm on thyroidectomy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.006). Malignant\/neoplastic outcomes did not correlate with sex or age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u2009.05). High free triiodothyronine\/free thyroxine levels were associated with a benign clinical outcome (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001). Cystic change on ultrasound was associated with a lower malignancy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.012) and neoplasm risk (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.041). Lesion size, echogenicity, vascularity, multinodularity, lymphadenopathy, and solid areas on ultrasound were not significant in predicting malignancy or neoplasm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of oncocytes in thyroid aspirates does not increase malignancy risk. Most malignant oncocytic thyroid aspirates are not attributable to oncocytic carcinomas but papillary thyroid carcinomas. Ultrasound and thyroid function tests are helpful in the risk assessment of these cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance<\/jats:title>\n                    <jats:p>For treatment or follow-up decisions in patients with oncocytes in thyroid aspirates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216251333358","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:27:28Z","timestamp":1747294048000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncocytes in Thyroid Aspirates\u2014Implications of Clinical Parameters and Cytologic Diagnosis"],"prefix":"10.1177","volume":"54","author":[{"given":"Joanna K. M.","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong"},{"name":"Department of Pathology, North District Hospital, Hong Kong, Hong Kong"},{"name":"Department of Pathology, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0314","authenticated-orcid":false,"given":"Joshua J. X.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matrix M. H.","family":"Fung","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip P. C.","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen K. W.","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vielh","sequence":"additional","affiliation":[{"name":"Medipath and American Hospital of Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20440"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0190"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0253"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22213"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7_1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.190447"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8_1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0141"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22955"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13110"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.701877"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.12.049"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0405"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22546"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20132"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2023-209250"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2015.11.05"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.02.025"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2928"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.15605\/jafes.034.02.14"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25236"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19160216251333358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19160216251333358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19160216251333358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:53:47Z","timestamp":1777589627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19160216251333358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"alternative-id":["10.1177\/19160216251333358"],"URL":"https:\/\/doi.org\/10.1177\/19160216251333358","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"19160216251333358"}}