{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:54:05Z","timestamp":1790610845849,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The extent of surgical resection for papillary thyroid carcinoma (PTCs) located in the isthmus has remained a matter of considerable debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the extent of wide-field isthmusectomy and complications and recurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Clinicopathologic documents of patients who received total thyroidectomy and wide-field isthmusectomy were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A retrospective review study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with single tumor in the isthmus with no cervical lymph node metastasis were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention or Exposures<\/jats:title>\n                    <jats:p>Patients received total thyroidectomy with neck dissection, or wide-field isthmusectomy with paratracheal and prelaryngeal lymph node dissection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The locoregional results, complications, and rate of patients who were not required to receive thyroid-stimulating hormone suppression therapy were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 389 patients were included in the study and divided into 3 groups. One hundred and nineteen (30.6%) patients were performed with wide-field isthmusectomy with a distance &lt;0.5\u2009cm (Group I), and 190 (48.8%) patients with a distance \u22650.5\u2009cm (Group II). Eighty (20.6%) underwent total thyroidectomy (Group III). Eighty (67.2%) of 119 patients in Group I and 125 (65.8%) of 190 patients in Group II did not take medication at the mean follow-up of 37\u2009months. Locoregional recurrence developed in 22 patients (18.5%) of Group I, 16 (8.4%) patients of Group II, and 5 (2.6%) patients of Group III. The overall morbidity was 6 (5.0%) in Group I, 14 (7.4%) in Group II, and 21 (26.5%) in Group III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Wide-field isthmusectomy with a 0.5\u2009cm distance may be a sufficient treatment for selected patients with PTC limited to the isthmus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance<\/jats:title>\n                    <jats:p>Wild-field isthmusectomy and limited neck dissection may be a sufficient procedure for isthmic PTC. Further research is needed to determine whether prophylactic central compartment neck dissection can be omitted during isthmusectomy for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216251348423","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T12:55:16Z","timestamp":1750856116000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognosis and Postoperative Complications of Wide-Field Isthmusectomy for Node-Negative Papillary Thyroid Carcinoma Limited to the Isthmus"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-1398","authenticated-orcid":false,"given":"Qianqian","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-7080","authenticated-orcid":false,"given":"Gaosong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06178-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.10.020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.620147"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01289-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09833-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.08.074"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2020.1749329"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0361"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00461-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.927407"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150212"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022552"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.04.039"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25926"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2018.94.5.229"}],"container-title":["Journal of Otolaryngology - Head &amp; 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