{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:52:17Z","timestamp":1777877537503,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research Project in Medical Science and Technology, Foshan Science and Technology Bureau","award":["232000100734"],"award-info":[{"award-number":["232000100734"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Effective anesthesia with minimal side effects is essential for pediatric patients undergoing adenoidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center, prospective, randomized controlled trial was conducted at Gaoming District People\u2019s Hospital (China, January 2022-October 2023). Two-hundred fifty-six children (ASA I-II, age 3-12\u2009years) scheduled for elective plasma radiofrequency adenoidectomy were randomized to 4 groups (n\u2009=\u200964 each). Group A received 0.9% normal saline; groups B, C, and D received continuous infusions of benzenesulfonate remimazolam at 0.4, 0.6, and 0.8\u2009mg\/kg\/h, respectively, combined with 6% sevoflurane for induction and 2% to 3% for maintenance. Primary outcomes were emergence time and postanesthesia care unit (PACU) stay. Secondary outcomes included incidence of adverse events, peak Pediatric Anesthesia Emergence Delirium (PAED) scores, and parental satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median awakening time was longer in groups B, C, and D than in group A (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). PACU stay was shorter in groups C and D versus group A (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Postoperative pain scores (Face, Legs, Activity, Cry, and Consolability) were lower in groups C and D than in groups A and B (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Peak PAED scores were lower in groups B, C, and D than in group A (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05); negative behavioral changes on postoperative day 3 were also reduced (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Parental satisfaction was higher in groups B, C, and D than in group A (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). No serious adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>Benzenesulfonate remimazolam (0.6\u2009mg\/kg\/h) combined with sevoflurane provides effective, safe anesthesia for pediatric plasma radiofrequency adenoidectomy, balancing induction efficacy, sedation depth, and safety. This regimen reduces emergence delirium, postoperative pain, and negative behavioral changes while enhancing parental satisfaction, supporting its use in pediatric adenoidectomy and warranting further investigation in other pediatric procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216251383860","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T18:19:58Z","timestamp":1761934798000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Application Study of Different Doses of Remimazolam Combined With Sevoflurane in Pediatric Adenoidectomy"],"prefix":"10.1177","volume":"54","author":[{"given":"Aiqun","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Gaoming District People\u2019s Hospital of Foshan, Foshan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Gaoming District People\u2019s Hospital of Foshan, Foshan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Gaoming District People\u2019s Hospital of Foshan, Foshan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3425-7598","authenticated-orcid":false,"given":"Meiyun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Boai Hospital of Zhongshan, Zhongshan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7692-6667","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Gaoming District People\u2019s Hospital of Foshan, Foshan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"issue":"9","key":"e_1_3_3_2_2","first-page":"1364","article-title":"Effect of low-temperature plasma ablation in tonsillectomy and adenoidectomy in children","volume":"43","author":"Yang ZG","year":"2021","unstructured":"Yang ZG, Zhang XJ, Xin SM, et al. 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