{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:32Z","timestamp":1791420812322,"version":"4.3.3"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271168"],"award-info":[{"award-number":["82271168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Haidian Innovation and Transformation Special Science and Technology Innovation Research and Development Project of Peking University Third Hospital","award":["HDCXZHKC2023202"],"award-info":[{"award-number":["HDCXZHKC2023202"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Peripheral blood inflammatory indices provide a noninvasive and cost-effective means to assess systemic inflammation. This study highlights the potential of pan-immune-inflammation value (PIV) as a reliable biomarker for obstructive sleep apnea (OSA) severity, with implications for clinical risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between peripheral blood inflammatory markers and OSA severity and identify predictive biomarkers for disease classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary academic medical center (Peking University Third Hospital), outpatient sleep clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>266 adults with snoring (18\u201370\u2009years) undergoing sleep monitoring, laryngoscopy, and blood tests. Exclusion criteria included recent infection, systemic illness, surgery, or pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention or Exposures<\/jats:title>\n                    <jats:p>No therapeutic intervention was performed. Exposures included varying severities of OSA and soft palate obstruction assessed by the M\u00fcller maneuver. Inflammatory indices (PIV, SIRI, SIL, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio [MLR], and platelet-to-lymphocyte ratio) were calculated from routine blood parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The primary outcome was the association between inflammatory indices and OSA severity as measured by apnea-hypopnea index (AHI). Secondary outcome was the correlation between inflammatory markers and soft palate-level obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PIV and SIRI were significantly elevated in severe OSA cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.012, respectively). PIV was independently associated with AHI severity (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20091.010, 95% CI [1.003, 1.017]). PIV and SIRI positively correlated with AHI (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009.236 and\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009.218, both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). MLR, PIV, and SIRI levels increased with greater soft palate collapse, though not independently predictive in multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PIV is an independent, accessible biomarker for assessing OSA severity. Composite indices (PIV, SIRI) may better reflect systemic inflammation than traditional single markers and could complement clinical phenotyping of OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance<\/jats:title>\n                    <jats:p>These findings support the use of composite inflammatory indices in OSA phenotyping and prognosis. Future studies should investigate inflammation-targeted strategies and validate these biomarkers in larger, multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216251407939","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T02:11:48Z","timestamp":1769479908000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation Between Peripheral Blood Inflammatory Markers and Obstructive Sleep Apnea Severity"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6296-4686","authenticated-orcid":false,"given":"Yingting","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(19)30198-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00248"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3070"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-458OC"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0013.6199"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.2.225"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13533"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076807"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13111300"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2023.2293409"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.01368"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.S317705"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1675517"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.525621"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1671-7368.2019.01.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812460505"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325105"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-07227-0"},{"key":"e_1_3_2_21_2","first-page":"63","article-title":"Predictive value of peripheral blood inflammatory markers for stroke in patients with obstructive sleep apnea hypopnea syndrome","volume":"33","author":"Gu Y PM","year":"2025","unstructured":"Gu Y PM, Zhou Y. 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