{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:14:37Z","timestamp":1787800477191,"version":"build-2784847793"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Vesale and Roi Baudouin Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Recent studies suggested that laryngopharyngeal reflux disease may be associated with chronic nasal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the prevalence and the pre- to posttreatment clinical findings of nasopharyngeal reflux disease (NRD) in patients with idiopathic chronic nasal complaints without allergy or chronic rhinosinusitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective uncontrolled preliminary study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with chronic idiopathic nasal complaints, without rhinosinusitis, allergic rhinitis, or other common sinonasal diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>From July 2022 to November 2024, patients underwent a 24\u2009hour nasopharyngeal pH-testing (Dx-pH system) for detecting NRD. Patients with NRD were treated with alginates or antacids for 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes<\/jats:title>\n                    <jats:p>Laryngopharyngeal and nasal symptoms and findings were evaluated from pre- to posttreatment with reflux symptom score (RSS), Sinonasal Outcome Test-22 (SNOT-22), and reflux sign assessment (RSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-three patients (15 females; mean age 50.1\u2009\u00b1\u200916.4\u2009years) were evaluated. NRD was identified in 26 patients (78.8%) with a mean of 85.6\u2009\u00b1\u200964.3 reflux events, predominantly alkaline (pH\u2009&gt;\u20096.0). Endoscopic findings included mulberry inferior turbinate (72.2%), crusts (38.9%), and dry nasal mucosa (27.8%). Posttreatment analysis revealed a significant reduction in RSS from 141.4\u2009\u00b1\u2009100.9 to 95.2\u2009\u00b1\u200982.6 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.015). While baseline SNOT-22 scores showed nonsignificant reduction posttreatment (46.2\u2009\u00b1\u200919.1 vs 36.0\u2009\u00b1\u200931.0), nasal RSA decreased significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.023). Nasal dryness was positively associated with the total upright reflux time (pH\u2009&lt;\u20096.5;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.575;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.016) and the number of acid reflux events (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.523;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.026), while the RSA pharynx was associated with the supine reflux time (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.573;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nasopharyngeal reflux, predominantly alkaline, shows high prevalence (78.8%) with characteristic endoscopic findings. Anti-reflux treatment significantly improves reflux symptoms and nasal scores, though overall sinonasal quality of life shows modest change.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216251409741","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:10:08Z","timestamp":1783055408000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Clinical Findings of Nasopharyngeal Reflux in Patients With Idiopathic Nasal Symptoms: A Preliminary Study"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Mons (UMons), Mons, Belgium"},{"name":"Department of Otolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France"},{"name":"Department of Otolaryngology and Head and Neck Surgery, CHU Saint-Pierre, Brussels, Belgium"},{"name":"Department of Otolaryngology, Elsan Hospital of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"441","article-title":"Chapter 16\u2014Diagnosis and management of rhinitis and rhinosinusitis","volume":"2022","author":"Sweis AM","unstructured":"Sweis AM, Kennedy DW. 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