{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:06:48Z","timestamp":1778990808072,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Sudden sensorineural hearing loss (SSNHL) significantly impacts quality of life. Identifying genetic and serological markers could improve early diagnosis and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential correlation between the miR-204-5p rs718447 polymorphism and the occurrence of SSNHL in the Chinese Han population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A hospital-based, case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Third People\u2019s Hospital of Hubei Province in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>One hundred forty patients with idiopathic SSNHL and 140 age-frequency-matched and sex-frequency-matched healthy controls of Chinese Han ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Genotyping was performed using the LightCycler 480 Real-Time PCR system. miR-204-5p expression was measured by RT-qPCR, while enzyme-linked immunosorbent assay was utilized to determine the interleukin-1\u03b2 (IL-1\u03b2) concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Primary: Association between rs718447 genotypes and SSNHL risk. Secondary: Diagnostic\/prognostic performance of miR-204-5p; correlations with IL-1\u03b2 and fibrinogen (FIB) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the SSNHL group, miR-204-5p was significantly elevated (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01). The A allele [odds ratio (OR)\u2009=\u20090.470, 95% confidence interval (CI): 0.297-0.744] and AG\/AA genotypes (OR\u2009=\u20090.486, 95% CI: 0.297-0.793) were identified as potential protective factors against SSNHL, whereas the GG genotype was associated with an increased risk of SSNHL. miR-204-5p expression progressively increased as hearing loss worsened from mild to severe, and GG genotype patients demonstrated higher miR-204-5p expression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01). The SSNHL group exhibited significantly higher IL-1\u03b2 and FIB concentrations, especially GG carriers (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Additionally, high miR-204-5p expression (OR\u2009=\u20093.039, 95% CI: 1.435-6.439,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.004) and the GG genotype at rs718447 (OR\u2009=\u20092.853, 95% CI: 1.095-7.433,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.032) were associated with poorer hearing recovery outcomes, with the GG genotype showing a correlation with poorer outcomes, consistent with a potential link involving miR-204-5p-associated inflammation and coagulation abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The miR-204-5p rs718447 polymorphism was associated with susceptibility to SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance<\/jats:title>\n                    <jats:p>These findings identify rs718447 and miR-204-5p as potential biomarkers for SSNHL. Future studies should validate these results in larger, multicenter cohorts and explore the underlying mechanisms to assess their utility in personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216261439052","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:21:38Z","timestamp":1778818898000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Analysis Between rs718447 Polymorphism of miR-204-5p and Sudden Sensorineural Hearing Loss in the Chinese Han Population"],"prefix":"10.1177","volume":"55","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Ezhou Central Hospital, Ezhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupeng","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7291-0584","authenticated-orcid":false,"given":"Fenglan","family":"Peng","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2014Head and Neck Surgery, The Third People\u2019s Hospital of Hubei Province, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148149"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.666651"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47472"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600406"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117392"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31308"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000497032"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3967\/bes2020.045"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320924312"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/nah.NAH_17_20"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fauot.2024.1400576"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1660"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9380398"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1377195"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309892"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4545"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4045-y"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.659517"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1497806"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-0860.2015.06.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47141-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.883749"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.659486"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06763-z"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000004168"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087307"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.01.017"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320944657"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2012.1631"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02378-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43800"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.927235"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002275"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.814891"}],"container-title":["Journal of Otolaryngology - Head &amp; 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