{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:04:14Z","timestamp":1784185454845,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Importance:<\/jats:title>\n                    <jats:p>Sensorineural hearing loss (SNHL) accompanied by vertigo is a condition with clinical heterogeneity. Understanding vascular underpinnings is crucial for management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association of systemic hemodynamics and endothelial dysfunction with the distinct clinical manifestations of SNHL with vertigo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A descriptive, hospital-based cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Department of Otolaryngology Head and Neck Surgery at a tertiary academic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>One hundred forty-two consecutive patients with SNHL and vertigo (disease duration \u226430\u2009days) enrolled between January 2023 and October 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>Observational study; no intervention was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Pure-tone audiometry (PTA) including high-frequency thresholds (6-8\u2009kHz), Dizziness Handicap Inventory (DHI), Tinnitus Evaluation Questionnaire, transcranial Doppler for mean flow velocity (Vm), and serum endothelin-1 (ET-1)\/nitric oxide (NO). Linear regression analyzed associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Linear regression showed PTA was significantly predicted by higher ET-1 (\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.37,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and lower NO. DHI was predicted by lower Vm (\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.40,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). High-frequency PTA (6-8\u2009kHz) was significantly worse in the Hearing Loss-Dominant (HLD) group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The HLD group (n\u2009=\u200975) exhibited significantly higher ET-1 levels compared to the Vertigo-Dominant (VD) group (n\u2009=\u200967) (85.4 vs 73.1\u2009pg\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Conversely, the VD group showed a more pronounced reduction in Vm (33.2 vs 38.5\u2009cm\/s,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Multiple linear regression identified ET-1 as the strongest predictor for PTA and Vm for DHI score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Systemic hemodynamic compromise and endothelial dysfunction differentially associate with hearing and vestibular phenotypes. Cochlear symptoms may be driven by endothelial-mediated vasoconstriction, while vestibular symptoms are more sensitive to macrovascular flow reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance:<\/jats:title>\n                    <jats:p>Vascular profiling could inform targeted therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19160216261454997","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:57:40Z","timestamp":1783943860000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis"],"prefix":"10.1177","volume":"55","author":[{"given":"Dongchen","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1186-1126","authenticated-orcid":false,"given":"Wu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3576-6535","authenticated-orcid":false,"given":"Zhijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First Hospital of Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0658"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1281689"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/01455613221139211"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15070725"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ms9.0000000000002579"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1127008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1658898"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00566.2022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-701"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.600985"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1505516"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073205"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03625-w"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres15020029"},{"issue":"6","key":"e_1_3_3_16_2","first-page":"344","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"60","author":"von Elm E","year":"2007","unstructured":"von Elm E, Altman DG, Egger M. 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