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There are several etiologies of hepatic necrosis, including toxins, drug injuries, viral infections, ischemic injuries, and metabolic disease, all of which possess overlapping gross and histologic presentations. Nonetheless, patterned necrosis in the context of clinical and demographic history allows for the forensic pathologist to develop a differential diagnosis, which may then be pruned into a specific or likely cause. The aim of the following review is to elucidate these patterns in the context of the liver diseases from which they arise with the goal developing a differential diagnosis and ultimate determination of etiology. Acad Forensic Pathol. 2018 8(2): 256-295<\/jats:p>","DOI":"10.1177\/1925362118782056","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T10:46:01Z","timestamp":1528281961000},"page":"256-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Differential Diagnosis of Hepatic Necrosis Encountered at Autopsy"],"prefix":"10.1177","volume":"8","author":[{"given":"Daniel C.","family":"Butler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas I.","family":"Batalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"bibr1-1925362118782056","doi-asserted-by":"crossref","unstructured":"Guicciardi ME, Gores GJ. 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