{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:39:13Z","timestamp":1777372753531,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Academic Forensic Pathology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Introduction: Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal dominant disorder that results from mutations in the collagen type III gene. It is a risk factor for medium-sized artery aneurysms, dissections, and ruptures. We report a case of hemoperitoneum due to medial dissection and rupture of the superior mesenteric artery related to vEDS. Methods: A full body CT scan and full three cavity autopsy was performed in a 47-year-old man with a history of an intermittent abdominal cramping for one week rand complex past medical history that included a sigmoid bowel perforation at age 20, and previous popliteal artery pseudoaneurysm rupture. Histology and genetic testing were performed. Results: The postmortem computed tomography and autopsy showed a significant hemoperitoneum due to a ruptured dissection of the superior mesenteric artery and branches, and multiple splanchnic artery dissections with renal and small bowel infarctions. Genetic testing revealed a heterozygous COL3A1 gene variant associated with Ehlers-Danlos syndrome. Death was attributed to hemoperitoneum due to medial dissection and rupture of the superior mesenteric artery due to arteriopathy. Discussion: The relatively young age and medical history correlate with the autopsy findings and genetic testing towards the conclusion of an arteriopathy consistent with vEDS.<\/jats:p>","DOI":"10.1177\/19253621241283723","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T03:12:02Z","timestamp":1727752322000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemoperitoneum Due to Dissection and Rupture of the Superior Mesenteric Artery in a Patient With COL3A1 Mutation"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5279-4466","authenticated-orcid":false,"given":"Fabio","family":"Tironi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wijesinghe","family":"Lakmali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-4824","authenticated-orcid":false,"given":"Jayantha","family":"Herath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"bibr1-19253621241283723","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20166615"},{"key":"bibr2-19253621241283723","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.953894"},{"key":"bibr3-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20181"},{"key":"bibr4-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2007.12.019"},{"key":"bibr5-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-007-0594-0"},{"key":"bibr6-19253621241283723","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47335"},{"key":"bibr7-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.rxeng.2022.11.004"},{"key":"bibr8-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2013.10.006"},{"key":"bibr9-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.04.039"},{"key":"bibr10-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-023-04112-8"},{"key":"bibr11-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098770"},{"key":"bibr12-19253621241283723","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48970"},{"key":"bibr13-19253621241283723","volume-title":"StatPearls [Internet]","author":"Taylor AM","year":"2023"},{"key":"bibr14-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.10.047"},{"key":"bibr15-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.179"},{"key":"bibr16-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.06.003"},{"key":"bibr17-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2018.1557507"},{"key":"bibr18-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-010-9205-6"},{"key":"bibr19-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200603000-00012"},{"key":"bibr20-19253621241283723","doi-asserted-by":"publisher","DOI":"10.6705\/j.jacme.202309_13(3).0004"},{"key":"bibr21-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.32"},{"key":"bibr22-19253621241283723","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.01.070"}],"container-title":["Academic Forensic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19253621241283723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19253621241283723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19253621241283723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:53:52Z","timestamp":1777366432000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19253621241283723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/19253621241283723"],"URL":"https:\/\/doi.org\/10.1177\/19253621241283723","relation":{},"ISSN":["1925-3621","1925-3621"],"issn-type":[{"value":"1925-3621","type":"print"},{"value":"1925-3621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}