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This article reviews environmental and toxicological factors that may contribute to adverse health outcomes in sealed vehicles, particularly in hot climates. Reports of fatal incidents have described sudden deaths occurring in enclosed vehicles during summer power outages with no evidence of trauma, intoxication, or carbon monoxide poisoning, suggesting hypoxia and exposure to accumulated gases. In such circumstances, multiple environmental factors may operate simultaneously. Vehicle interior materials are known to emit volatile organic compounds (VOCs) including aromatic hydrocarbons, aldehydes, and ketones, especially under elevated temperatures. Solar heating can raise cabin temperatures to 40-70\u2005\u00b0C, increasing emission rates and reducing air exchange when ventilation is limited. Under these conditions, accumulation of VOCs may occur together with oxygen depletion, carbon dioxide buildup, and severe heat stress. 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