{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:12:19Z","timestamp":1778969539166,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the feasibility of an implantable subconjunctival glucose monitoring system (SGMS) for long-term glucose monitoring, we investigated the in vivo performance of the system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>The SGMS consists of an implantable ocular mini implant (OMI) and a handheld fluorescence photometer. A clinical study was performed on 47 diabetes patients split into two cohorts. Two different types of OMI were used, with and without a biocompatible surface coating. Duration of the study was 1 year. Correlation between capillary blood glucose and SGMS-derived interstitial fluid glucose was investigated during the first 6 months of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both OMI types were tolerated well in the eyes of the patients. At the beginning of the study, the SGMS of both cohorts revealed a high accuracy with mean absolute relative difference (MARD) values of 7\u201312%. The performance of the uncoated OMIs deteriorated within 3 months of wearing time, exhibiting a MARD value of 20%. The performance of the surface-coated OMIs was preserved longer. Glucose correlation measurement with reasonable results (MARD of 14%) could be performed for up to 6 months of wear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The biocompatible surface coating on the OMIs enabled a longer duration of action of up to 6 months compared with 3 months for uncoated implants in a clinical trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/193229681300700104","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T10:36:05Z","timestamp":1389350165000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood Glucose Self-Monitoring with a Long-Term Subconjunctival Glucose Sensor"],"prefix":"10.1177","volume":"7","author":[{"given":"Achim Josef","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Eyesense GmbH, Grossostheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Knuth","sequence":"additional","affiliation":[{"name":"Eyesense GmbH, Grossostheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina Sibylle","family":"Nikolaus","sequence":"additional","affiliation":[{"name":"Eyesense GmbH, Grossostheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Kriv\u00e1nek","sequence":"additional","affiliation":[{"name":"Eyesense GmbH, Grossostheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"K\u00fcster","sequence":"additional","affiliation":[{"name":"Eyesense GmbH, Grossostheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hasslacher","sequence":"additional","affiliation":[{"name":"Diabetesinstitut Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd Uwe","family":"Auffarth","sequence":"additional","affiliation":[{"name":"University Eye Clinic, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"bibr1-193229681300700104","volume-title":"IDF diabetes atlas.","author":"International Diabetes 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