{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:24:47Z","timestamp":1785803087859,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hypoglycemia is often the limiting factor for intensive glucose control in diabetes management, however its actual prevalence in type 2 diabetes (T2DM) is not well documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A total of 108 patients with T2DM wore a continuous glucose monitoring system (CGMS) for 5 days. Rates and patterns of hypoglycemia and glycemic variability (GV) were calculated. Patient and medication factors were correlated with rates, timing, and severity of hypoglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the patients, 49.1% had at least 1 hypoglycemic episode (mean 1.74 episodes\/patient\/ 5 days of CGMS) and 75% of those patients experienced at least 1 asymptomatic hypoglycemic episode. There was no significant difference in the frequency of daytime versus nocturnal hypoglycemia. Hypoglycemia was more frequent in individuals on insulin (alone or in combination) ( P = .02) and those on oral hypoglycemic agents ( P &lt; .001) compared to noninsulin secretagogues. CGMS analysis resulted in treatment modifications in 64% of the patients. T2DM patients on insulin exhibited higher glycemic variability (GV) scores (2.3 \u00b1 0.6) as compared to those on oral medications (1.8 \u00b1 0.7, P = .017).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CGMS can provide rich data that show glucose excursions in diabetes patients throughout the day. Consequently, unwarranted onset of hypo- and hyperglycemic events can be detected, intervened, and prevented by using CGMS. Hypoglycemia was frequently unrecognized by the patients in this study (75%), which increases their potential risk of significant adverse events. Incorporation of CGMS into the routine management of T2DM would increase the detection and self-awareness of hypoglycemia resulting in safer and potentially better overall control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1932296815581052","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:03:05Z","timestamp":1430168585000},"page":"999-1005","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":116,"title":["Hypoglycemia in Type 2 Diabetes - More Common Than You Think"],"prefix":"10.1177","volume":"9","author":[{"given":"Richa Redhu","family":"Gehlaut","sequence":"first","affiliation":[{"name":"Ohio University Heritage College of Osteopathic Medicine\/O\u2019Bleness Memorial Hospital, Diabetes Institute, Ohio University, Athens, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin Y.","family":"Dogbey","sequence":"additional","affiliation":[{"name":"Heritage College of Osteopathic Medicine\/CORE Research Office, Ohio University, Athens OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Diabetes Institute, Ohio University, Athens, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia R.","family":"Marling","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering and Computer Science, Russ College of Engineering and Technology and the Diabetes Institute, Ohio University, Athens, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Shubrook","sequence":"additional","affiliation":[{"name":"Touro University California, College of Osteopathic Medicine, Vallejo, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"bibr1-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0822-9"},{"key":"bibr2-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.12.2948"},{"key":"bibr3-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"bibr4-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4909"},{"key":"bibr5-1932296815581052","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-8-201104190-00007"},{"key":"bibr6-1932296815581052","doi-asserted-by":"publisher","DOI":"10.4158\/EP.17.2.287"},{"key":"bibr7-1932296815581052","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2012.01.2525"},{"key":"bibr8-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S58813"},{"key":"bibr9-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.01.002"},{"key":"bibr10-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1824"},{"key":"bibr11-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440360095010"},{"key":"bibr12-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"bibr13-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.8.1113"},{"key":"bibr14-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00429-3.x"},{"key":"bibr15-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2008.0047"},{"key":"bibr16-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.01.064"},{"key":"bibr17-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984452"},{"key":"bibr18-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1328"},{"key":"bibr19-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2337\/diab.19.9.644"},{"key":"bibr20-1932296815581052","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0077"},{"key":"bibr21-1932296815581052","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0063"},{"key":"bibr22-1932296815581052","unstructured":"Joy NG, Tate DB, Younk LM, Davis SN. Effects of acute and antecedent hypoglycemia on endothelial function and markers of atherothrombotic balance in healthy man [published online ahead of print February 18, 2015]. 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