{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:04:07Z","timestamp":1791417847493,"version":"4.3.3"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic continuous glucose monitoring options for animal research have been very limited due to various technical and biological challenges. We provide an evaluation of a novel telemetry device for continuous monitoring of temperature, activity, and plasma glucose levels in the arterial blood of rats for up to 2 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In vivo testing in rats including oral glucose tolerance tests (OGTTs) and intraperitoneal glucose tolerance tests (IPGTTs) and ex vivo waterbath testing were performed to evaluate acute and chronic sensor performance. Animal studies were in accordance with the guidelines for the care and use of laboratory animals and approved by the corresponding animal care and use committees (Data Sciences International, Eli Lilly).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Results demonstrated the ability to record continuous measurements for 75 days or longer. Bench testing demonstrated a high degree of linearity over a range of 20-850 mg\/dL with\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = .998 for linear fit and .999 for second order fit (n = 8 sensors). Evaluation of 6 rats over 28 days with 52 daily and OGTT test strip measurements each resulted in mean error of 3.8% and mean absolute relative difference of 16.6%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This device provides significant advantages in the quality and quantity of data that can be obtained relative to existing alternatives such as intermittent blood sampling. These devices provide the opportunity to expand the understanding of both glucose metabolism and homeostasis and to work toward improved therapies and cures for diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1932296815586424","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T20:29:50Z","timestamp":1432844990000},"page":"771-781","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Fully Implantable Arterial Blood Glucose Device for Metabolic Research Applications in Rats for Two Months"],"prefix":"10.1177","volume":"9","author":[{"given":"Robert","family":"Brockway","sequence":"first","affiliation":[{"name":"Data Sciences International, Inc (DSI), Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Tiesma","sequence":"additional","affiliation":[{"name":"Data Sciences International, Inc (DSI), Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Bogie","sequence":"additional","affiliation":[{"name":"Data Sciences International, Inc (DSI), Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"White","sequence":"additional","affiliation":[{"name":"Data Sciences International, Inc (DSI), Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Fine","sequence":"additional","affiliation":[{"name":"Data Sciences International, Inc (DSI), Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libbey","family":"O\u2019Farrell","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Michael","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Cox","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Coskun","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(84)90018-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1962.tb13623.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01637680"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0002."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2405."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4109(200108)13:12<983::AID-ELAN983>3.0.CO;2-#"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400507."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400222."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-9998"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.2.1012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.10.002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2007.0257."},{"key":"e_1_3_2_14_2","volume-title":"Poster presented at: Experimental Biology Annual Meeting","author":"Peterson RG","unstructured":"Peterson RG, Brockway R. Assessment of Nova biomedical statstrip glucose meters and test strips in rat glucose studies. Poster presented at: Experimental Biology Annual Meeting; April 21-25, 2012; San Diego, CA."},{"key":"e_1_3_2_15_2","volume-title":"Poster presented at: American Diabetes Association 74th Scientific Sessions","author":"Ailllon DV","unstructured":"Ailllon DV, Naylor E, Harmon HP, . A two-week continuous glucose monitoring system for subcutaneous implantation in rodents. Poster presented at: American Diabetes Association 74th Scientific Sessions; June 13-17, 2014; San Francisco, CA."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.023"}],"container-title":["Journal of Diabetes Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1932296815586424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1932296815586424","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1932296815586424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:11:53Z","timestamp":1777399913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1932296815586424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,27]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1177\/1932296815586424"],"URL":"https:\/\/doi.org\/10.1177\/1932296815586424","relation":{},"ISSN":["1932-2968","1932-2968"],"issn-type":[{"value":"1932-2968","type":"print"},{"value":"1932-2968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,27]]}}}