{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:08:31Z","timestamp":1790201311513,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Calibra Medical (Wayne, PA), which has since been acquired by CeQur SA (Horw, Switzerland)."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>CeQur Simplicity\u2122 (CeQur, Marlborough, MA) is a 3-day insulin delivery patch designed to meet mealtime insulin requirements. A recently reported 48-week, randomized, multicenter, interventional trial compared efficacy, safety and self-reported outcomes in 278 adults with type 2 diabetes (T2D) on basal insulin therapy who initiated and managed mealtime insulin therapy with a patch pump versus insulin pen. We assessed changes in key glycemic metrics among a subset of patients who wore a continuous glucose monitoring (CGM) device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Study participants (patch, n = 49; pen, n = 48) wore a CGM device in masked setting during the baseline period and prior to week 24. Glycemic control was assessed using international consensus guidelines for percentage of Time In Range (%TIR: &gt;70% at 70-180\u2009mg\/dL), Time Below Range (%TBR: &lt;4% at &lt;70\u2009mg\/dL; &lt;1% at &lt;54\u2009mg\/dL), and Time Above Range (%TAR: &lt;25% at &gt;180\u2009mg\/dL; &lt;5% at &gt;250\u2009mg\/dL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both the patch and pen groups achieved recommended targets in %TIR (74.1%\u2009\u00b1\u200918.7%, 75.2\u2009\u00b1\u200916.1%, respectively) and marked reductions in %TAR &gt;180\u2009mg\/dL (21.1%\u2009\u00b1\u200919.9%, 19.7%\u2009\u00b1\u200917.5%, respectively) but with increased %TBR &lt;70\u2009mg\/dL (4.7%\u2009\u00b1\u20095.2%, 5.1\u2009\u00b1\u20095.8, respectively), all P &lt; .0001. No significant between-group differences in glycemic improvements or adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CGM confirmed that the patch or pen can be used to safely initiate and optimize basal-bolus therapy using a simple insulin adjustment algorithm with SMBG. Preference data suggest that use of the patch vs pen may enhance treatment adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968211016513","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T07:32:21Z","timestamp":1621409541000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparing Patch vs Pen Bolus Insulin Delivery in Type 2 Diabetes Using Continuous Glucose Monitoring Metrics and Profiles"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5584","authenticated-orcid":false,"given":"Richard M.","family":"Bergenstal","sequence":"first","affiliation":[{"name":"International Diabetes Center, Park Nicollet, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"International Diabetes Center, Park Nicollet, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanita R.","family":"Aroda","sequence":"additional","affiliation":[{"name":"Medstar Health Research Institute, Hyattsville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Brazg","sequence":"additional","affiliation":[{"name":"Rainier Clinical Research Center, Renton, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene M.","family":"Dreon","sequence":"additional","affiliation":[{"name":"Calibra Medical, Johnson & Johnson Diabetes Care Companies, Wayne, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Frias","sequence":"additional","affiliation":[{"name":"National Research Institute, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida F.","family":"Kruger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Bone and Mineral Disease, Henry Ford Health System, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Molitch","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Molecular Medicine at the Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-2889","authenticated-orcid":false,"given":"Deborah M.","family":"Mullen","sequence":"additional","affiliation":[{"name":"International Diabetes Center, Park Nicollet, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Peyrot","sequence":"additional","affiliation":[{"name":"Loyola University Maryland, Department of Sociology, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Richter","sequence":"additional","affiliation":[{"name":"Professional Data Analysts, GBC, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Rosenstock","sequence":"additional","affiliation":[{"name":"Dallas Diabetes Research Center at Medical City, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Serusclat","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Mutualiste Les Portes du Sud, Ve\u2019nissieux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Vance","sequence":"additional","affiliation":[{"name":"Rocky Mountain Diabetes Center, Idaho Falls, Idaho, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-5666","authenticated-orcid":false,"given":"Ruth S.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, SUNY Upstate Medical University, Syracuse, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Calibra Medical, Johnson & Johnson Diabetes Care Companies, Wayne, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"bibr1-19322968211016513","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.17.2254"},{"key":"bibr2-19322968211016513","doi-asserted-by":"publisher","DOI":"10.1186\/1750-4732-1-9"},{"issue":"11","key":"bibr3-19322968211016513","volume":"14","author":"Zhou J","year":"2008","journal-title":"Med Sci 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