{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:55:57Z","timestamp":1793728557463,"version":"4.6.1"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AVAZZIA Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Electrical stimulation (E-Stim) may offer a unique adjunctive treatment to heal complicated diabetic foot ulcers (DFU). Our primary goal is to examine the effectiveness of daily home-based E-Stim therapy to speed-up wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients with chronic DFUs and mild to severe peripheral arterial disease (PAD) were recruited and randomized to either control (CG) or intervention (IG) groups. The IG received 1-hour home-based E-Stim therapy on daily basis for 4 weeks (4W). E-Stim was delivered through electrical pads placed above the ankle joint using a bio-electric stimulation technology (BEST\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) platform (Tennant Biomodulator\n                      <jats:sup>\u00ae<\/jats:sup>\n                      PRO). The CG was provided with an identical but non-functional device for the same period. The primary outcome included wound area reduction at 4W from baseline (BL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-eight patients were recruited and 5 were removed due to non-compliance or infection, leaving 33 participants (IG, n = 16; CG, n =17). At 4W, the IG showed a significant wound area reduction of 22% (BL: 7.4 \u00b1 8.5 cm\n                      <jats:sup>2<\/jats:sup>\n                      vs 4W: 5.8 \u00b1 8.0 cm\n                      <jats:sup>2<\/jats:sup>\n                      , P = 0.002). Average of wound area was unchanged in the CG ( P = 0.982). The self-report adherence to daily home-therapy was 93.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Daily home-based E-Stim provides early results on the feasibility, acceptability, and effectiveness of E-Stim as an adjunctive therapy to speed up wound healings in patients with chronic DFU and mild to severe PAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968211035128","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T06:21:51Z","timestamp":1627626111000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Home-Based Electrical Stimulation to Accelerate Wound Healing\u2014A Double-Blinded Randomized Control Trial"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-6882","authenticated-orcid":false,"given":"Alejandro","family":"Zulbaran-Rojas","sequence":"first","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Park","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesreen","family":"El-Refaei","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lepow","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"bibr1-19322968211035128","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v4i0.22081."},{"key":"bibr2-19322968211035128","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1364158"},{"key":"bibr3-19322968211035128","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002680"},{"key":"bibr4-19322968211035128","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0445"},{"key":"bibr5-19322968211035128","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12594"},{"key":"bibr6-19322968211035128","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13179"},{"key":"bibr7-19322968211035128","unstructured":"Proper Usage of Electrical Stimulation. 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