{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:07:14Z","timestamp":1790845634318,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["951933"],"award-info":[{"award-number":["951933"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["17-2011-515"],"award-info":[{"award-number":["17-2011-515"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DP3DK101068"],"award-info":[{"award-number":["DP3DK101068"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK085628"],"award-info":[{"award-number":["R01DK085628"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery\u2014meal announcement\u2014and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa\/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual\u2014not actual\u2014transit space for insulin delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968221076559","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T01:44:31Z","timestamp":1644543871000},"page":"751-756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling"],"prefix":"10.1177","volume":"17","author":[{"given":"Jorge","family":"Lo Presti","sequence":"first","affiliation":[{"name":"Department of Woman\u2019s and Child\u2019s Health, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-3056","authenticated-orcid":false,"given":"Alfonso","family":"Galderisi","sequence":"additional","affiliation":[{"name":"Department of Woman\u2019s and Child\u2019s Health, University of Padova, Padova, Italy"},{"name":"H\u00f4pital Necker-Enfants Malades, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-9114","authenticated-orcid":false,"suffix":"III","given":"Francis J.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Zisser","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Dassau","sequence":"additional","affiliation":[{"name":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, Nutrition and INSERM Clinical Investigation Center 1411, University Hospital of Montpellier, Montpellier, France"},{"name":"Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-3456","authenticated-orcid":false,"given":"Chiara","family":"Toffanin","sequence":"additional","affiliation":[{"name":"Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-6682","authenticated-orcid":false,"given":"Claudio","family":"Cobelli","sequence":"additional","affiliation":[{"name":"Department of Woman\u2019s and Child\u2019s Health, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"bibr1-19322968221076559","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31947-0"},{"issue":"3","key":"bibr2-19322968221076559","first-page":"738","volume":"77","author":"Giacca A","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr3-19322968221076559","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90136-6"},{"key":"bibr4-19322968221076559","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90164-5"},{"key":"bibr5-19322968221076559","volume-title":"Introduction to Modelling in Physiology and Medicine","author":"Cobelli C","year":"2019","edition":"2"},{"key":"bibr6-19322968221076559","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1080"},{"key":"bibr7-19322968221076559","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12999"},{"key":"bibr8-19322968221076559","doi-asserted-by":"publisher","DOI":"10.1109\/TMRB.2021.3075775"},{"key":"bibr9-19322968221076559","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11090600"},{"key":"bibr10-19322968221076559","unstructured":"Moret F, Schiavon M, Cobelli C, Dalla Man C. 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