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The initial focus of the DFC is to develop and validate biomarkers for DFUs that can be used in clinical care and research. The DFC consists of a data coordinating center (DCC) for operational oversight and statistical analysis, clinical sites for participant recruitment and evaluation, and biomarker analysis units (BAUs). The DFC is currently studying biomarkers to predict wound healing and recurrence and is collecting biosamples for future studies through a biorepository. The DFC plans to address the challenges of recruitment and eligibility criteria for DFU clinical trials by taking an approach of \u201cNo DFU Patient Goes Unstudied.\u201d In this platform approach, clinical history, DFU outcome, wound imaging, and biologic measurements from a large number of patients will be captured and the in-depth longitudinal data set will be analyzed to develop a computational-based DFU risk factor profile to facilitate scientifically sound clinical trial design. The DFC will expand its platform to include studies of the role of social determinants of health, such as food insecurity, housing instability, limited health literacy, and poor social support. The DFC is starting partnerships with the broad group of stakeholders in the wound care community.<\/jats:p>","DOI":"10.1177\/19322968221121152","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T07:27:03Z","timestamp":1662190023000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["The NIDDK Diabetic Foot Consortium"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-2322","authenticated-orcid":false,"given":"Teresa L.Z.","family":"Jones","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal M.","family":"Holmes","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Katona","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika A.","family":"Niewczas","sequence":"additional","affiliation":[{"name":"Section on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-1350","authenticated-orcid":false,"given":"Rodica","family":"Pop-Busui","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-9243","authenticated-orcid":false,"given":"Brian M.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan K.","family":"Sen","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine and Indiana University Health Comprehensive Wound Center, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjana","family":"Tomic-Canic","sequence":"additional","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristidis","family":"Veves","sequence":"additional","affiliation":[{"name":"The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"bibr1-19322968221121152","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10029"},{"key":"bibr2-19322968221121152","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"bibr3-19322968221121152","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S011"},{"key":"bibr4-19322968221121152","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310799"},{"key":"bibr5-19322968221121152","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"bibr6-19322968221121152","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0571"},{"key":"bibr7-19322968221121152","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0743"},{"key":"bibr8-19322968221121152","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK326791\/. 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