{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:34:53Z","timestamp":1792294493075,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the progression of diabetic retinopathy (DR) after the initiation of automated insulin delivery (AID) systems in adults with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this longitudinal study with 152 adults, retinal exams and clinical variables were collected before and after AID initiation up to 2.7 years. The DR worsening was defined as an increase in Early Treatment of Diabetic Retinopathy Study (ETDRS) scores or qualitative retinal exam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 152 adults with mean age of 42 years (57% female), 26 years of T1D duration, and mean baseline HbA\n                      <jats:sub>1c<\/jats:sub>\n                      of 7.6% (60 mmol\/mol) were included in this analysis. Of 152 adults with T1D, 42 (28%) adults had DR worsening after AID initiation. After adjusting for age, diabetes duration, and sex, baseline HbA\n                      <jats:sub>1c<\/jats:sub>\n                      (odds ratio [OR] = 2.1 [1.34-3.04]) and low-density lipoprotein cholesterol (LDL-C) &gt;100 mg\/dL with HbA\n                      <jats:sub>1c<\/jats:sub>\n                      &gt;8% (OR = 3.33 [1.12-9.91]) were associated with two- and three-fold increased risk for DR worsening, respectively. The decline of HbA\n                      <jats:sub>1c<\/jats:sub>\n                      with AID initiation between DR worsening and no-DR worsening groups was not significant (\u22120.38 \u00b1 1.2% vs \u22120.47 \u00b1 0.9%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Higher baseline HbA\n                      <jats:sub>1c<\/jats:sub>\n                      with LDL-C &gt;100 mg\/dL may be associated with DR worsening after initiation of AID systems in T1D. Those with elevated HbA\n                      <jats:sub>1c<\/jats:sub>\n                      should get periodic ophthalmic examination after AID initiation to detect progression of DR. Prompt diagnosis may result in timely treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968251318740","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:44:26Z","timestamp":1739511866000},"page":"1159-1163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Progression of Diabetic Retinopathy After Initiation of Automated Insulin Delivery System in Adults With Type 1 Diabetes"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-5206","authenticated-orcid":false,"given":"Kagan E.","family":"Karakus","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5179","authenticated-orcid":false,"given":"Halis K.","family":"Akturk","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-3740","authenticated-orcid":false,"given":"Janet K.","family":"Snell-Bergeon","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3827-7107","authenticated-orcid":false,"given":"Viral N.","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Medicine, Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13538"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13172"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.7.874"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01190-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205225"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907863"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0172"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11708"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004736"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296820986879"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38012-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.10.014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408093110604"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0904"},{"key":"e_1_3_2_17_2","article-title":"10. Cardiovascular disease and risk management: standards of care in diabetes\u20142023","volume":"46","author":"ElSayed NA","year":"2022","unstructured":"ElSayed NA, Aleppo G, Aroda VR, et al. 10. Cardiovascular disease and risk management: standards of care in diabetes\u20142023. Diabetes Care. 2022;46(suppl 1):S158-S190.","journal-title":"Diabetes Care"},{"key":"e_1_3_2_18_2","article-title":"12. Retinopathy, neuropathy, and foot care: standards of care in diabetes\u20142023","volume":"46","author":"ElSayed NA","year":"2022","unstructured":"ElSayed NA, Aleppo G, Aroda VR, et al. 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes\u20142023. Diabetes Care. 2022;46(suppl 1):S203-15.","journal-title":"Diabetes Care"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4959-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2062"},{"key":"e_1_3_2_21_2","unstructured":"NHS. Diabetic retinopathy. Accessed December 4 2024. Published 2021. https:\/\/www.nhs.uk\/conditions\/diabetic-retinopathy\/"},{"key":"e_1_3_2_22_2","unstructured":"NHS England. Hybrid closed loop technologies: 5-year implementation strategy. Published 2024. Accessed December 4 2024. https:\/\/www.england.nhs.uk\/long-read\/hybrid-closed-loop-technologies-5-year-implementation-strategy\/"}],"container-title":["Journal of Diabetes Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19322968251318740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19322968251318740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19322968251318740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:58:30Z","timestamp":1784635110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19322968251318740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/19322968251318740"],"URL":"https:\/\/doi.org\/10.1177\/19322968251318740","relation":{},"ISSN":["1932-2968","1932-2968"],"issn-type":[{"value":"1932-2968","type":"print"},{"value":"1932-2968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]}}}