{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:08:53Z","timestamp":1784635733596,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0210104h0001, 19ek0210104h0002, 20ek0210104h00"],"award-info":[{"award-number":["18ek0210104h0001, 19ek0210104h0002, 20ek0210104h00"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan IDDM Network, Non-Profit Corporation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The relationship between the percent coefficient of variation (%CV) and the risk of severe hypoglycemia (SH) or non-severe hypoglycemia (NSH) in patients with type 1 diabetes (T1D) remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus (ISCHIA) study was a crossover, randomized, controlled trial for hypoglycemia prevention in patients with T1D using multiple daily injections (MDIs). Blinded continuous glucose monitoring (CGM) data of 93 patients obtained during the Control period (84 days) were used for the post hoc analysis. The receiver operating characteristics (ROC) curves were analyzed to determine the discrimination thresholds of %CV corresponding to the low blood glucose index (LBGI) &gt; 5 and LBGI \u2265 2.5, and the occurrence of SH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The %CV corresponding to LBGI &gt; 5 and LBGI \u2265 2.5 was 42.2% and 37.0%, respectively. The episodes of SH were observed in three patients, and the %CV corresponding to the occurrence of SH was 40.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The identification of the discrimination threshold of %CV associated with the risk of SH or NSH in patients with T1D is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968251318756","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:22:46Z","timestamp":1739780566000},"page":"1285-1292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Relationship Between the Percent Coefficient of Variation of Sensor Glucose Levels and the Risk of Severe Hypoglycemia or Non-Severe Hypoglycemia in Patients With Type 1 Diabetes: Post Hoc Analysis of the ISCHIA Study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-9657","authenticated-orcid":false,"given":"Takashi","family":"Murata","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, NHO Kyoto Medical Center, Kyoto, Japan"},{"name":"Diabetes Center, NHO Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehide","family":"Matsuhisa","sequence":"additional","affiliation":[{"name":"Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Ogura","sequence":"additional","affiliation":[{"name":"Diabetes Center, NHO Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Social and Community Pharmacy, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kato","sequence":"additional","affiliation":[{"name":"Diabetes Center, NHO Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Tone","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, NHO Kokura Medical Center, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Meguro","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnosuke","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Diabetology and Metabolism, Department of Internal Medicine, School of Medicine, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Hosoda","sequence":"additional","affiliation":[{"name":"Diabetes Center, Koseikai Takeda Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sakane","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The ISCHIA Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00609"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15384"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1769"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1426"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13886"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0016"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab688"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.1870"},{"key":"e_1_3_4_11_2","first-page":"59","article-title":"Protocol for a randomized, crossover trial to decrease time in hypoglycemia by combined intervention of the usage of intermittent-scanning continuous glucose monitoring device and the structured education regarding its usage: effect of intermittent-scanning continuous glucose monitoring to glycemic control including hypoglycemia and quality of life of patients with type 1 diabetes mellitus study (ISCHIA Study)","volume":"46","author":"Suzuki S","year":"2021","unstructured":"Suzuki S, Tone A, Murata T, et al. Protocol for a randomized, crossover trial to decrease time in hypoglycemia by combined intervention of the usage of intermittent-scanning continuous glucose monitoring device and the structured education regarding its usage: effect of intermittent-scanning continuous glucose monitoring to glycemic control including hypoglycemia and quality of life of patients with type 1 diabetes mellitus study (ISCHIA Study). Tokai J Exp Clin Med. 2021;46:59-68.","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.110147"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2010.00074.x"},{"key":"e_1_3_4_14_2","first-page":"811","article-title":"Consensus and statement on international standardization of HbA1C in Japan: committee report on diabetes mellitus laboratory testing standardization","volume":"52","author":"Kashiwagi A","year":"2009","unstructured":"Kashiwagi A, Kadowaki T, Haneda M, et al. Consensus and statement on international standardization of HbA1C in Japan: committee report on diabetes mellitus laboratory testing standardization. J Jpn Diabetes Soc. 2009;52: 811\u2013818. (In Japanese)","journal-title":"J Jpn Diabetes Soc"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319880041"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218178"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-023-01144-4"},{"key":"e_1_3_4_18_2","unstructured":"Ministry of Health Labour and Welfare. Clinical Trials Act (Act No. 16 of April 14 2017). 2017. https:\/\/www.mhlw.go.jp\/file\/06-Seisakujouhou-10800000-Iseikyoku\/0000213334.pdf. Accessed October 23 2024."}],"container-title":["Journal of Diabetes Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19322968251318756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19322968251318756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19322968251318756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:58:49Z","timestamp":1784635129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19322968251318756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/19322968251318756"],"URL":"https:\/\/doi.org\/10.1177\/19322968251318756","relation":{},"ISSN":["1932-2968","1932-2968"],"issn-type":[{"value":"1932-2968","type":"print"},{"value":"1932-2968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]}}}