{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:39:27Z","timestamp":1792935567417,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004374","name":"medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Diabetes Sci Technol"],"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The MiniMed 780G (MM780G) automated insulin delivery (AID) system has been shown to improve glycemic control in people with type 1 diabetes (T1D). The aim was to determine the long-term cost-effectiveness of the MM780G versus multiple daily injections of insulin plus continuous glucose monitoring (MDI+CGM) in people with T1D in Hong Kong.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The analysis was performed using the IQVIA Core Diabetes Model. The primary analysis was performed in adults with HbA1c \u22658%, from a payer perspective over a time horizon of 60 years and annual discount rate of 3%. Clinical input data were sourced from a clinical trial, wherein HbA1c reductions from baseline (9.04%) of 1.54% and 0.2% were assumed for MM780G and MDI+CGM, respectively. A secondary analysis was performed for a cohort of children\/adolescents starting treatment at &lt;18 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the adult base case analysis, the incremental cost-effectiveness ratio (ICER) for MM780G versus MDI+CGM was HKD 348\u2009927 (USD 44\u2009759) per quality-adjusted life year (QALY) gained. In the pediatric analysis, the ICER for MM780G versus MDI+CGM was HKD 300\u2009466 (USD 38\u2009543) per QALY. The use of MM780G was predicted to result in reductions in the incidence of diabetes-related complications in both analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Over a long-term time horizon, the use of MM780G was projected to improve clinical outcomes versus MDI+CGM. The MM780G was found to be cost-effective versus MDI+CGM in adults with T1D in Hong Kong who are not achieving glycemic targets; benefits were more pronounced in pediatric users, underscoring the value of initiating AID therapy at a younger age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19322968261494594","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:55:31Z","timestamp":1792666531000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term Cost-Effectiveness of an Automated Insulin Delivery System Versus Multiple Daily Injections of Insulin Plus Continuous Glucose Monitoring in Children and Adults With Type 1 Diabetes in Hong Kong"],"prefix":"10.1177","author":[{"given":"Elaine","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Chung","family":"Yau","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The Chinese University of Hong Kong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131 Zeynep Ozdemir","family":"Saltik","sequence":"additional","affiliation":[{"name":"Medtronic International Trading S\u00e0rl, Tolochenaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hill","sequence":"additional","affiliation":[{"name":"Medtronic International Trading S\u00e0rl, Tolochenaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2494-7000","authenticated-orcid":false,"given":"Martin","family":"Field","sequence":"additional","affiliation":[{"name":"Covalence Research Ltd, Harpenden, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-7507","authenticated-orcid":false,"given":"Richard F.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Covalence Research Ltd, Harpenden, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"de Portu","sequence":"additional","affiliation":[{"name":"Medtronic International Trading S\u00e0rl, Tolochenaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Type 1 Diabetes Index. 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