{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:13:59Z","timestamp":1783494839274,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Medical Acupuncture"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Asthma is a chronic inflammatory disease affecting millions of people globally. Chronic asthma is generally resistant to steroid therapy. Acupuncture has anti-inflammatory effects and has been widely used as an adjuvant therapy for asthma. This study aims to evaluate the effects of acupuncture at Feishu (BL-13) only and BL-13 and Zusanli stomach (ST-36) on immunoglobulin E (IgE) levels of the chronic asthma mice model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>BALB\/c mice were sensitized using ovalbumin (OVA) to induce a chronic asthma mouse model by injecting OVA intraperitoneally on days 0 and 14 and followed by aerosol exposure of OVA 1% three times\/week for 6 weeks. The 28 mice were randomized into four groups: Control group, untreated asthma group, asthma + BL-13, and asthma + BL-13 + ST-36. For the treatment group, manual acupuncture (MA) was done three times\/week for 6 weeks at BL-13 only or BL-13 and ST-36. At the end of the experiment, blood samples were taken to determine IgE levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussions:<\/jats:title>\n                    <jats:p>\n                      This study found significantly lower IgE levels after MA at BL-13 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.009) and BL-13 + ST-36 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.018) compared with the control group. Acupuncture is able to stimulate sympathetic nerves, stimulating Beta-2 (\u03b22) adrenergic receptors. Moreover, acupuncture reduces T helper-2 (Th2) cytokines and restores the balance of Th1\/Th2 cytokines, which might affect the IgE level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acupuncture at BL-13 and BL-13 + ST-36 acupoints is able to demonstrate a lower concentration of IgE in the chronic asthma mice model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19336586261444174","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:45:16Z","timestamp":1776228316000},"page":"264-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Acupuncture at Feishu and Zusanli on Immunoglobulin E Levels in Chronic Asthma Mice Model"],"prefix":"10.1177","volume":"38","author":[{"given":"Ida","family":"Nurwati","sequence":"first","affiliation":[{"name":"Acupuncture Research Group, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Central Java, Indonesia."},{"name":"Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthmainah","family":"Muthmainah","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selfi","family":"Handayani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyonisa Nasirochmi","family":"Pakha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus Jati","family":"Sunggoro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02475-6"},{"key":"e_1_3_3_3_1","unstructured":"2.World Health Organization. Asthma. 2023. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/asthma#:\u223c:text=Asthma%20affected%20an%20estimated%20262 help%20to%20reduce%20asthma%20symptoms [Last accessed: April16 2024]."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.02.011"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2020.1443"},{"key":"e_1_3_3_6_1","unstructured":"5.Hashmi MF Tariq M Cataletto ME. Asthma. 2023. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430901\/ [Last accessed: April16 2024]."},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.006"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-114"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/647308"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.01.005"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.03.010"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0964528418818705"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2007.04.004"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.02.003"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000312635"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0083OC"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2015.1111"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1013-7025(07)70006-4"},{"key":"e_1_3_3_19_1","first-page":"1","article-title":"Examining the effector mechanisms of the feishu acupoint (BL13) in the treatment of pneumonia based on systematic acupuncture and moxibustion research","volume":"2021","author":"Xu Y","year":"2021","unstructured":"18.Xu Y, , Cai J, , Li W, et al. Examining the effector mechanisms of the feishu acupoint (BL13) in the treatment of pneumonia based on systematic acupuncture and moxibustion research. Evidence-Based Complementary Alternative Med 2021;2021:1\u201311.","journal-title":"Evidence-Based Complementary Alternative Med"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S462262"},{"key":"e_1_3_3_21_1","volume-title":"Contemporary meridians and acupoints in practice","author":"Yeh ML","year":"2004","unstructured":"20.Yeh ML, , Chen HH, , Lin IH. Contemporary meridians and acupoints in practice. 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