{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:16:52Z","timestamp":1770502612931,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1177\/1933719107303986","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T23:57:42Z","timestamp":1184975862000},"page":"338-348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High Expression of Human Telomerase Reverse Transcriptase in High-Grade Intraepithelial Neoplasia and Carcinoma of Uterine Cervix and Its Correlation With Human Papillomavirus Infection"],"prefix":"10.1007","volume":"14","author":[{"given":"Po-Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin-Den","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Ping","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Yau","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn-Liang","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,12,30]]},"reference":[{"key":"14040338_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1046\/j.1341-8076.2003.00126.x","volume":"29","author":"UB Saraiya","year":"2003","unstructured":"Saraiya UB. Preventable but not prevented: the reality of cervical cancer. J Obstet Gynaecol Res. 2003;29:351\u2013359.","journal-title":"J Obstet Gynaecol Res"},{"key":"14040338_CR2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/0002-9378(69)90268-3","volume":"5","author":"RM Richart","year":"1969","unstructured":"Richart RM, Barron BA. A follow-up of patients with cervical dysplasia. Am J Obstet Gynecol. 1969;5:386\u2013393.","journal-title":"Am J Obstet Gynecol"},{"key":"14040338_CR3","first-page":"447","volume-title":"Novak\u2019s Gynecology","author":"KD Hatch","year":"1996","unstructured":"Hatch KD, Hacker NF. Intraepithelial disease of the cervix, vagina, and vulva. In: Berek JS, Adashi EY, Hillard PA, eds. Novak\u2019s Gynecology. 12th ed. Baltimore, MD: Williams & Wilkins; 1996:447\u2013448.","edition":"12"},{"key":"14040338_CR4","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/jama.1989.03430070079034","volume":"262","author":"National Cancer Institute Workshop","year":"1989","unstructured":"National Cancer Institute Workshop. The 1988 Bethesda system for reporting cervical\/vaginal cytological diagnoses. JAMA. 1989;262:931\u2013934.","journal-title":"JAMA"},{"key":"14040338_CR5","first-page":"678","volume-title":"Principles and Practice of Gynecologic Oncology","author":"TC Wright Jr","year":"1997","unstructured":"Wright TC Jr, Richart RM. Pathogenesis and diagnosis of preinvasive lesions of the lower genital tract. In: Hoskins WJ, Perez CA, Young RC, eds. Principles and Practice of Gynecologic Oncology. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997:678\u2013680.","edition":"2"},{"key":"14040338_CR6","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00003081-200006000-00015","volume":"45","author":"AP Pinto","year":"2000","unstructured":"Pinto AP, Crum CP. Natural history of cervical neoplasia: defining progression and its consequence. Clin Obstet Gynecol. 2000;45:352\u2013362.","journal-title":"Clin Obstet Gynecol"},{"key":"14040338_CR7","first-page":"17","volume":"21","author":"MF Mitchell","year":"1996","unstructured":"Mitchell MF, Tortolero-Luna G, Wright T, et al. Cervical human papillomavirus infection and intraepithelial neoplasia: a review. J Natl Cancer Inst Monogr. 1996;21:17\u201325.","journal-title":"J Natl Cancer Inst Monogr"},{"key":"14040338_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/35040500","volume":"408","author":"EH Blackburn","year":"2000","unstructured":"Blackburn EH. Telomere states and cell fates. Nature. 2000; 408:53\u201356.","journal-title":"Nature"},{"key":"14040338_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1073\/pnas.95.1.90","volume":"95","author":"CW Greider","year":"1998","unstructured":"Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci U S A. 1998;95:90\u201392.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"14040338_CR10","first-page":"263","volume":"29","author":"CB Harley","year":"1997","unstructured":"Harley CB, Sherwood SW. Telomerase, checkpoints and cancer. Cancer Surv. 1997;29:263\u2013284.","journal-title":"Cancer Surv"},{"key":"14040338_CR11","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","volume":"33","author":"JW Shay","year":"1997","unstructured":"Shay JW, Bacchetti S. Telomerase activity in human cancer. Eur J Cancer. 1997;33:787\u2013791.","journal-title":"Eur J Cancer"},{"key":"14040338_CR12","doi-asserted-by":"publisher","first-page":"6476","DOI":"10.1073\/pnas.93.13.6476","volume":"93","author":"C Harle-Bachor","year":"1996","unstructured":"Harle-Bachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci U S A. 1996;93:6476\u20136481.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"14040338_CR13","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/S0959-8049(97)00059-2","volume":"33","author":"KF Norrback","year":"1997","unstructured":"Norrback KF, Roos G. Telomeres and telomerase activity in normal and malignant haematopoietic cells. Eur J Cancer. 1997;33:774\u2013780.","journal-title":"Eur J Cancer"},{"key":"14040338_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1126\/science.279.5349.349","volume":"279","author":"AG Bodnar","year":"1998","unstructured":"Bodnar AG, Ouellette M, Frolkis M, et al. Extension of lifespan by introduction of telomerase into normal human cells. Science. 1998;279:349\u2013352.","journal-title":"Science"},{"key":"14040338_CR15","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/sj.onc.1201882","volume":"16","author":"CM Counter","year":"1998","unstructured":"Counter CM, Meyerson M, Eaton EN, et al. Telomerase activity is restored in human cells by ectopic expression hTERT (hEST2), the catalytic subunit of temomerase. Oncogene. 1998;16:1217\u20131222.","journal-title":"Oncogene"},{"key":"14040338_CR16","first-page":"1558","volume":"58","author":"M Takakura","year":"1998","unstructured":"Takakura M, Kyo S, Kanaya T, Tanaka M, Inoue M. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res. 1998;58:1558\u20131561.","journal-title":"Cancer Res"},{"key":"14040338_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0960-9822(98)70067-3","volume":"8","author":"TL Beattie","year":"1998","unstructured":"Beattie TL, Zhou W, Robinson MO, Harrington L. Reconstitution of human telomerase activity in vitro. Curr Biol. 1998;8: 177\u2013180.","journal-title":"Curr Biol"},{"key":"14040338_CR18","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/ng1297-498","volume":"17","author":"SL Weinrich","year":"1997","unstructured":"Weinrich SL, Pruzan R, Ma L, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Gene. 1997;17:498\u2013502.","journal-title":"Nat Gene"},{"key":"14040338_CR19","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1053\/hupa.2000.19299","volume":"31","author":"GB Wisman","year":"2000","unstructured":"Wisman GB, De Jong S, Meersma GJ, et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol. 2000;31: 1304\u20131312.","journal-title":"Hum Pathol"},{"key":"14040338_CR20","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.4049\/jimmunol.166.8.4826","volume":"166","author":"K Liu","year":"2001","unstructured":"Liu K, Hodes RH, Weng Np. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol. 2001;166:4826\u20134830.","journal-title":"J Immunol"},{"key":"14040338_CR21","first-page":"18","volume":"63","author":"M Akiyama","year":"2003","unstructured":"Akiyama M, Hideshima T, Hayashi T, et al. Nuclear factor-\u03baB p65 mediates tumor necrosis factor \u03b1-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 2003;63:18\u201321.","journal-title":"Cancer Res"},{"key":"14040338_CR22","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1128\/JCM.44.5.1733-1739.2006","volume":"44","author":"SL Huang","year":"2006","unstructured":"Huang SL, Chao A, Hsueh S, et al. Comparison between the Hybrid Capture II Test and an SPF1\/GP6+ PCR-based assay for detection of human papillomavirus DNA in cervical swab samples. J Clin Microbiol. 2006;44:1733\u20131739.","journal-title":"J Clin Microbiol"},{"key":"14040338_CR23","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1136\/ijgc-00009577-200407000-00012","volume":"14","author":"HJ Huang","year":"2004","unstructured":"Huang HJ, Huang SL, Lin CY, et al. Human papillomavirus genotyping by a polymerase chain reaction\u2014based genechip method in cervical carcinoma treated with neoadjuvant chemotherapy plus radical surgery. Int J Gynecol Cancer. 2004; 14:639\u2013649.","journal-title":"Int J Gynecol Cancer"},{"key":"14040338_CR24","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1128\/JCM.34.9.2095-2100.1996","volume":"34","author":"F Karlsen","year":"1996","unstructured":"Karlsen F, Kalantari M, Jenkins A, et al. Use of multiple PCR primer sets for optimal detection of human papillomavuirs. J Clin Microbiol. 1996;34:2095\u20132100.","journal-title":"J Clin Microbiol"},{"key":"14040338_CR25","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/jcp.2005.033142","volume":"59","author":"M Branca","year":"2006","unstructured":"Branca M, Giorgi C, Ciotti M, et al. Down-regulated nucleoside diphosphate (NDP) kinase nm23-H1 expression is unrelated to high-risk human papillomavirus (HPV) but associated with progression of CIN and unfavourable prognosis in cervical cancer. J Clin Pathol. 2006;59:1044\u20131051.","journal-title":"J Clin Pathol"},{"key":"14040338_CR26","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1309\/XWFE-ARMN-HG2D-AJYV","volume":"114","author":"M Frost","year":"2000","unstructured":"Frost M, Bobak JB, Gianani R, et al. Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix. Am J Clin Pathol. 2000;114:726\u2013734.","journal-title":"Am J Clin Pathol"},{"key":"14040338_CR27","first-page":"433","volume":"13","author":"S Yasumoto","year":"1996","unstructured":"Yasumoto S, Kunimura C, Kikuchi K, et al.Telomerase activity in normal human epithelial cells. Oncogene. 1996;13:433\u2013439.","journal-title":"Oncogene"},{"key":"14040338_CR28","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1136\/jcp.2004.024158","volume":"58","author":"S Bravaccini","year":"2005","unstructured":"Bravaccini S, Sanchini MA, Amadori A, et al. Potential of telomerase expression and activity in cervical specimens as a diagnostic tool. J Clin Pathol. 2005;58:911\u2013914.","journal-title":"J Clin Pathol"},{"key":"14040338_CR29","doi-asserted-by":"publisher","first-page":"7441","DOI":"10.1038\/sj.onc.1207527","volume":"23","author":"A Zhang","year":"2004","unstructured":"Zhang A, Wang J, Zheng B, et al. Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix. Oncogene. 2004;23:7441\u20137447.","journal-title":"Oncogene"},{"key":"14040338_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1177\/153537020523000406","volume":"230","author":"A Tsezou","year":"2005","unstructured":"Tsezou A, Oikonomou P, Kollia P, et al. The role of human telomerase catalytic subunit mRNA expression in cervical dyplasias. Exp Biol Med. 2005;230:263\u2013270.","journal-title":"Exp Biol Med"},{"key":"14040338_CR31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/ajcp\/114.3.371","volume":"114","author":"H Wada","year":"2000","unstructured":"Wada H, Enomoto T, Yoshino K, et al. Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia. Am J Clin Pathol. 2000;114:371\u2013379.","journal-title":"Am J Clin Pathol"},{"key":"14040338_CR32","first-page":"1849","volume":"3","author":"M Engelhardt","year":"1997","unstructured":"Engelhardt M, Albanell J, Drullinsky P, et al. Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon and sarcoma. Clin Cancer Res. 1997;3:1849\u20131857.","journal-title":"Clin Cancer Res"},{"key":"14040338_CR33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.humpath.2005.09.031","volume":"37","author":"P Oikonomou","year":"2006","unstructured":"Oikonomou P, Mademtzis I, Messinis I, Tsezou A. Quantitative determination of human telomerase reverse transcriptase messenger RNA expression in premalignant cervical lesions and correlation with human papillomavirus load. Hum Pathol. 2006;37:135\u2013142.","journal-title":"Hum Pathol"},{"key":"14040338_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/380079a0","volume":"380","author":"AJ Klingelhutz","year":"1996","unstructured":"Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature. 1996;380:79\u201382.","journal-title":"Nature"},{"key":"14040338_CR35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ygyno.2004.03.041","volume":"94","author":"E Jeong Seo","year":"2004","unstructured":"Jeong Seo E, Jung Kim H, Jae Lee C, Tae Kang H, Seong Hwang E. The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells. Gynecol Oncol. 2004;94:40\u201347.","journal-title":"Gynecol Oncol"},{"key":"14040338_CR36","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.1128\/JVI.75.12.5559-5566.2001","volume":"75","author":"ST Oh","year":"2001","unstructured":"Oh ST, Kyo S, Laimins LA. Telomerase activation by human papillomavirus type E6 portein: induction of human telomerase reverse transcriptase expression through Myc and GCrich Sp1 binding sites. J Virol. 2001;75:5559\u20135566.","journal-title":"J Virol"},{"key":"14040338_CR37","doi-asserted-by":"publisher","first-page":"8211","DOI":"10.1073\/pnas.1435900100","volume":"100","author":"T Veldman","year":"2003","unstructured":"Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci U S A. 2003;100:8211\u20138216.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"14040338_CR38","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1002\/1097-0142(19951115)76:10+<1902::AID-CNCR2820761306>3.0.CO;2-0","volume":"76","author":"TW Park","year":"1995","unstructured":"Park TW, Fujiwara H, Wright TC. Molecular biology of cervical cancer and its precursors. Cancer. 1995;76:1902\u20131913.","journal-title":"Cancer"},{"key":"14040338_CR39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1346-8138.2000.tb02126.x","volume":"27","author":"T Ishiji","year":"2000","unstructured":"Ishiji T. Molecular mechanism of carcinogenesis by human papillomavirus-16. J Dermatol. 2000;27:73\u201386.","journal-title":"J Dermatol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719107303986.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719107303986\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719107303986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719107303986.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:05:12Z","timestamp":1656810312000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719107303986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["14040338"],"URL":"https:\/\/doi.org\/10.1177\/1933719107303986","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"30 December 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}