{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:58:20Z","timestamp":1767859100725,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1177\/1933719107307821","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T17:36:57Z","timestamp":1193247417000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Expression of Corticotropin-Releasing Hormone Receptor Type 1 and Type 2 in Human Pregnant Myometrium"],"prefix":"10.1007","volume":"14","author":[{"given":"Dan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingji","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,12,31]]},"reference":[{"key":"1406568_CR1","first-page":"34","volume":"21","author":"HJ Lenz","year":"1987","unstructured":"Lenz HJ, Raedler A., Greten H., Brown MR CRF initiates biological action within the brain that are observed in response to stress. Am J Physiol. 1987;21:34\u201339.","journal-title":"Am J Physiol"},{"key":"1406568_CR2","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jama.1992.03480090092034","volume":"267","author":"G Chrousos","year":"1992","unstructured":"Chrousos G., Gold P. The concepts of stress and stress system disorders. JAMA. 1992;267:1244\u20131252.","journal-title":"JAMA"},{"key":"1406568_CR3","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1210\/jcem-59-5-861","volume":"55","author":"T Suda","year":"1984","unstructured":"Suda T., Tomori N., Tozawa F., Mouri T., Demura H., Shizume K. Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissue. J Clin Endocrinol Metab. 1984;55:861\u2013866.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1210\/jcem-55-2-384","volume":"55","author":"T Shibasai","year":"1982","unstructured":"Shibasai T., Oagirl Ehizume K, Ling N. Corticotropin-releasing factor-like activity in human extracts. J Clin Endocrinol Metab. 1982;55:384\u2013386.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR5","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1210\/mend-2-9-871","volume":"2","author":"T Usui","year":"1988","unstructured":"Usui T., Nakai Y., Tsukada T., et al. Expression of adrenocorticotropin-releasing hormone precursor gene in placenta and other nonhypothalamic tissues in man. Mol Endocrinol. 1988;2:871\u2013875.","journal-title":"Mol Endocrinol"},{"key":"1406568_CR6","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/0306-4530(95)00011-9","volume":"20","author":"EB De Souza","year":"1995","unstructured":"De Souza EB Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology. 1995;20:789\u2013818.","journal-title":"Psychoneuroendocrinology"},{"key":"1406568_CR7","first-page":"425","volume":"43","author":"MJ Owens","year":"1991","unstructured":"Owens MJ, Nemeroff CB Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev. 1991;43:425\u2013473.","journal-title":"Pharmacol Rev"},{"key":"1406568_CR8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/nm0595-460","volume":"1","author":"M McLean","year":"1995","unstructured":"McLean M., Bistis A., Davies JJ, Woods R., Lowry PJ, Smith R. A placental clock controlling the length of human pregnancy. Nat Med. 1995;1:460\u2013463.","journal-title":"Nat Med"},{"key":"1406568_CR9","doi-asserted-by":"publisher","first-page":"8967","DOI":"10.1073\/pnas.90.19.8967","volume":"90","author":"R Chen","year":"1993","unstructured":"Chen R., Lewis KA, Perrin MH, Vale WW Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A. 1993;90:8967\u20138971.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1406568_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1210\/endo.137.1.8536644","volume":"137","author":"CW Liaw","year":"1996","unstructured":"Liaw CW, Lovenberg TW, Barry G., Oltersdorf T., Grigoriadis DE, De Souza EB. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology. 1996;137:72\u201377.","journal-title":"Endocrinology"},{"key":"1406568_CR11","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1096\/fj.01-0487fje","volume":"15","author":"A Pisarchik","year":"2001","unstructured":"Pisarchik A., Slominski AT Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J. 2001;15:2754\u20132756.","journal-title":"FASEB J"},{"key":"1406568_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0167-4781(97)00047-X","volume":"1352","author":"O Valdenaire","year":"1997","unstructured":"Valdenaire O., Giller T., Breu V., Gottowik J., Kilpatrick G. A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. Biochim Biophys Acta. 1997;1352:129\u2013132.","journal-title":"Biochim Biophys Acta"},{"key":"1406568_CR13","first-page":"1077","volume":"12","author":"WA Kostich","year":"1998","unstructured":"Kostich WA, Chen A., Sperle K., Largent BL Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2\u03b3 receptor. Mol Endocrinol. 1998;12:1077\u20131085.","journal-title":"Mol Endocrinol"},{"key":"1406568_CR14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/378287a0","volume":"378","author":"J Vaughan","year":"1996","unstructured":"Vaughan J., Donaldson C., Bittencourt J., et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotrophin-releasing factor. Nature. 1996;378:287\u2013292.","journal-title":"Nature"},{"key":"1406568_CR15","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/87936","volume":"7","author":"SY Hsu","year":"2001","unstructured":"Hsu SY, Hsueh AJ Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med. 2001;7:605\u2013611.","journal-title":"Nat Med"},{"key":"1406568_CR16","doi-asserted-by":"publisher","first-page":"7570","DOI":"10.1073\/pnas.121165198","volume":"98","author":"K Lewis","year":"2001","unstructured":"Lewis K., Li C., Perrin MH, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001;98:7570\u20137575.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1406568_CR17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0022-3565(24)29670-1","volume":"296","author":"FM Dautzenberg","year":"2001","unstructured":"Dautzenberg FM, Py-Lang G., Higelin J., Fischer C., Wright MB, Huber G. Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences. J Pharmacol Exp Ther. 2001;296:113\u2013120.","journal-title":"J Pharmacol Exp Ther"},{"key":"1406568_CR18","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1677\/jme.0.0320339","volume":"32","author":"B Sehringer","year":"2004","unstructured":"Sehringer B., Zahradnik HP, Simon M., Ziegler R., Noethling C., Schaefer WR mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR. J Mol Endocrinol. 2004; 32:339\u2013348.","journal-title":"J Mol Endocrinol"},{"key":"1406568_CR19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ajog.2005.12.048","volume":"195","author":"A Imperatore","year":"2006","unstructured":"Imperatore A., Florio P., Torres PB, et al. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. Am J Obstet Gynecol. 2006;195:288\u2013295.","journal-title":"Am J Obstet Gynecol"},{"key":"1406568_CR20","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1210\/en.2003-1210","volume":"145","author":"E Karteris","year":"2004","unstructured":"Karteris E., Hillhous EW, Grammatopoulos DK Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 conticotropin-releasing hormone receptor in the control of myometrial contractility. Endocrinology. 2004;145:890\u2013900.","journal-title":"Endocrinology"},{"key":"1406568_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1210\/jcem-64-2-224","volume":"64","author":"A Sasaki","year":"1987","unstructured":"Sasaki A., Shinkawa O., Margioris AN, et al. Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor and delivery. J Clin Endocrinol Metab. 1987; 64:224\u2013229.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR22","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/S0002-9378(11)90606-1","volume":"166","author":"WB Warren","year":"1992","unstructured":"Warren WB, Patrick SL, Goland RS Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by preterm labor. Am J Obstet Gynecol. 1992;166:1198\u20131204.","journal-title":"Am J Obstet Gynecol"},{"key":"1406568_CR23","first-page":"2539","volume":"83","author":"D Grammatopoulos","year":"1998","unstructured":"Grammatopoulos D., Dai Y., Chen J., et al. Human corticotropin-releasing hormone receptor: difference in subtype expression between pregnant and nonpregnant myometria. J Clin Endocrinol Metab. 1998;83:2539\u20132544.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1677\/joe.0.1560015","volume":"156","author":"B Rodriguez-Linares","year":"1998","unstructured":"Rodriguez-Linares B., Linton EA, Phaneuf S. Expression of corticotrophin-releasing hormone receptor mRNA and protein in the human myometrium. J Endocrinol. 1998;156:15\u201321.","journal-title":"J Endocrinol"},{"key":"1406568_CR25","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1055\/s-2003-39778","volume":"111","author":"B Wetzka","year":"2003","unstructured":"Wetzka B., Sehringer B., Sch\u00e4fer WR, et al. Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term. Exp Clin Endocrinol Diabetes. 2003;111:154\u2013161.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1406568_CR26","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1073\/pnas.052296399","volume":"99","author":"E Aggelidou","year":"2002","unstructured":"Aggelidou E., Hillhouse EW, Grammatopoulos D. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotrophin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Proc Natl Acad Sci U S A. 2002;99:3300\u20133305.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1406568_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1159\/000061042","volume":"27","author":"EW Hillhouse","year":"2001","unstructured":"Hillhouse EW, Grammatopoulos D. Control of intracellular signaling by corticotropin-releasing hormone in human myometrium. Front Horm Res. 2001;27:66\u201374.","journal-title":"Front Horm Res"},{"key":"1406568_CR28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156\u2013159.","journal-title":"Anal Biochem"},{"key":"1406568_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1677\/jme.0.0320021","volume":"32","author":"E Kateris","year":"2004","unstructured":"Kateris E., Papadopoulou N., Grammatopoulos DK, Hillhouse EW Expression and signaling characteristics of the corticotrophin-releasing hormone receptors during the implantation phase in the human endometrium. J Mol Endocrinol. 2004;32:21\u201332.","journal-title":"J Mol Endocrinol"},{"key":"1406568_CR30","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402\u2013408.","journal-title":"Methods"},{"key":"1406568_CR31","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1111\/j.1432-1033.2004.04216.x","volume":"271","author":"A Pisarchik","year":"2004","unstructured":"Pisarchik A., Slominski A. Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem. 2004;271:2821\u20132830.","journal-title":"Eur J Biochem"},{"key":"1406568_CR32","first-page":"4107","volume":"83","author":"MY Stevens","year":"1998","unstructured":"Stevens MY, Challis Jrg, Lye SJ Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium. J Clin Endocrinol Metab. 1998;83:4107\u20134115.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR33","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1210\/mend.13.12.0391","volume":"13","author":"D Grammatopoulos","year":"1999","unstructured":"Grammatopoulos D., Dai Y., Randeva HS, et al. A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. Mol Endocrinol. 1999;13:2189\u20132202.","journal-title":"Mol Endocrinol"},{"key":"1406568_CR34","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1210\/jc.2005-0680","volume":"90","author":"R Sirianni","year":"2005","unstructured":"Sirianni R., Mayhew BA, Carr BR, Parker CR, Rainey WE Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells. J Clin Endocrinol Metab. 2005;90:5393\u20135400.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1210\/jc.2002-020375","volume":"88","author":"E Karteris","year":"2003","unstructured":"Karteris E., Goumenou A., Koumantakis E., Hillhouse EW, Grammatopoulos DK Reduced expression of corticotropin-releasing hormone receptor type-1\u03b1 in human preeclamptic and growth-restricted placentas. J Clin Endocrinol Metab. 2003;88:363\u2013370.","journal-title":"J Clin Endocrinol Metab"},{"key":"1406568_CR36","first-page":"2076","volume":"14","author":"DK Grammatopoulos","year":"2000","unstructured":"Grammatopoulos DK, Randeva HS, Levine MA, Katsanou ES, Hillhouse EW Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: an effect mediated via R1alpha and R2beta CRH receptor subtypes and stimulation of Gq-proteins. Mol Endocrinol. 2000;14:2076\u20132091.","journal-title":"Mol Endocrinol"},{"key":"1406568_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1471-4159.1999.0720388.x","volume":"72","author":"S Wille","year":"1999","unstructured":"Wille S., Sydow S., Palchaudhuri MR, Spiess J., Dautzenberg FM Identification of amino acids in the N-terminal domain of corticotropin-releasing factor receptor 1 that are important determinants of high-affinity ligand binding. J Neurochem. 1999;72:388\u2013395.","journal-title":"J Neurochem"},{"key":"1406568_CR38","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1210\/er.2005-0034","volume":"27","author":"EW Hillhouse","year":"2006","unstructured":"Hillhouse EW, Grammatopoulos DK The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev. 2006;27:260\u2013286.","journal-title":"Endocr Rev"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719107307821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719107307821\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719107307821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719107307821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T21:33:03Z","timestamp":1737495183000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719107307821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["1406568"],"URL":"https:\/\/doi.org\/10.1177\/1933719107307821","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"31 December 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}