{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:40:45Z","timestamp":1785451245731,"version":"3.56.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1177\/1933719108314624","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T21:38:04Z","timestamp":1214429884000},"page":"484-492","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["HB-EGF but Not Amphiregulin or Their Receptors HER1 and HER4 Is Altered in Endometrium of Women With Unexplained Infertility"],"prefix":"10.1007","volume":"15","author":[{"given":"Lusine","family":"Aghajanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Bjuresten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Altm\u00e4e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Marie","family":"Landgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Stavreus-Evers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,31]]},"reference":[{"key":"15050484_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0020-7292(01)00381-2","volume":"73","author":"G Wyshak","year":"2001","unstructured":"Wyshak G. Infertility in American college alumnae. Int J Gynaecol Obstet. 2001;73:237\u2013242.","journal-title":"Int J Gynaecol Obstet"},{"key":"15050484_CR2","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1093\/humrep\/13.7.1825","volume":"13","author":"MG Hull","year":"1998","unstructured":"Hull MG, Williams JA, Ray B, et al. The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: a controlled comparison with tubal infertility and use of donor spermatozoa. Hum Reprod. 1998;13:1825\u20131830.","journal-title":"Hum Reprod"},{"key":"15050484_CR3","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1093\/humrep\/16.12.2587","volume":"16","author":"AK Omland","year":"2001","unstructured":"Omland AK, Fedorcsak P, Storeng R, et al. Natural cycle IVF in unexplained, endometriosis-associated and tubal factor infertility. Hum Reprod. 2001;16:2587\u20132592.","journal-title":"Hum Reprod"},{"key":"15050484_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0014-4827(02)00105-2","volume":"284","author":"RC Harris","year":"2003","unstructured":"Harris RC, Chung E, Coffey RJ. EGF receptor ligands. Exp Cell Res. 2003;284:2\u201313.","journal-title":"Exp Cell Res"},{"key":"15050484_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0014-4827(02)00101-5","volume":"284","author":"A Citri","year":"2003","unstructured":"Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res. 2003;284:54\u201365.","journal-title":"Exp Cell Res"},{"key":"15050484_CR6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S0014-4827(02)00100-3","volume":"284","author":"G Carpenter","year":"2003","unstructured":"Carpenter G. ErbB-4: mechanism of action and biology. Exp Cell Res. 2003;284:66\u201377.","journal-title":"Exp Cell Res"},{"key":"15050484_CR7","doi-asserted-by":"publisher","first-page":"26761","DOI":"10.1074\/jbc.272.42.26761","volume":"272","author":"K Elenius","year":"1997","unstructured":"Elenius K, Corfas G, Paul S, et al. A novel juxtamembrane domain isoform of HER4\/ErbB4: isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 1997;272:26761\u201326768.","journal-title":"J Biol Chem"},{"key":"15050484_CR8","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.1840698","volume":"251","author":"S Higashiyama","year":"1991","unstructured":"Higashiyama S, Abraham JA, Miller J, et al. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991;251:936\u2013939.","journal-title":"Science"},{"key":"15050484_CR9","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/molehr\/gah207","volume":"11","author":"K Ejskjaer","year":"2005","unstructured":"Ejskjaer K, Sorensen BS, Poulsen SS, et al. Expression of the epidermal growth factor system in human endometrium during the menstrual cycle. Mol Hum Reprod. 2005;11:543\u2013551.","journal-title":"Mol Hum Reprod"},{"key":"15050484_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.fertnstert.2005.08.011","volume":"85","author":"XX Sun","year":"2006","unstructured":"Sun XX, Gemzell-Danielsson K, Li HZ, et al. Expression of heparin-binding epidermal growth factor-like growth factor and its receptors in the human fallopian tube and endometrium after treatment with mifepristone. Fertil Steril. 2006;85:171\u2013178.","journal-title":"Fertil Steril"},{"key":"15050484_CR11","first-page":"F179","volume":"1333","author":"G Raab","year":"1997","unstructured":"Raab G, Klagsbrun M. Heparin-binding EGF-like growth factor. Biochim Biophys Acta. 1997;1333:F179\u2013F199.","journal-title":"Biochim Biophys Acta"},{"key":"15050484_CR12","first-page":"3355","volume":"84","author":"RE Leach","year":"1999","unstructured":"Leach RE, Khalifa R, Ramirez ND, et al. Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. J Clin Endocrinol Metab. 1999;84:3355\u20133363.","journal-title":"J Clin Endocrinol Metab"},{"key":"15050484_CR13","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/molehr\/8.8.765","volume":"8","author":"A Stavreus-Evers","year":"2002","unstructured":"Stavreus-Evers A, Aghajanova L, Brismar H, et al. Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation. Mol Hum Reprod. 2002;8:765\u2013769.","journal-title":"Mol Hum Reprod"},{"key":"15050484_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0015-0282(16)59406-0","volume":"48","author":"E Johannisson","year":"1987","unstructured":"Johannisson E, Landgren BM, Rohr HP, et al. Endometrial morphology and peripheral hormone levels in women with regular menstrual cycles. Fertil Steril. 1987;48:401\u2013408.","journal-title":"Fertil Steril"},{"key":"15050484_CR15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","volume":"122","author":"RW Noyes","year":"1975","unstructured":"Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975;122:262\u2013263.","journal-title":"Am J Obstet Gynecol"},{"key":"15050484_CR16","first-page":"1026","volume":"11","author":"R Higuchi","year":"1993","unstructured":"Higuchi R, Fockler C, Dollinger G, et al. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N Y). 1993;11:1026\u20131030.","journal-title":"Biotechnology (N Y)"},{"key":"15050484_CR17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1677\/joe.0.1470553","volume":"147","author":"K Adachi","year":"1995","unstructured":"Adachi K, Kurachi H, Adachi H, et al. Menstrual cycle specific expression of epidermal growth factor receptors in human fallopian tube epithelium. J Endocrinol. 1995;147:553\u2013563.","journal-title":"J Endocrinol"},{"key":"15050484_CR18","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1210\/jc.2004-0476","volume":"90","author":"K Chobotova","year":"2005","unstructured":"Chobotova K, Karpovich N, Carver J, et al. Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocrinol Metab. 2005;90:913\u2013919.","journal-title":"J Clin Endocrinol Metab"},{"key":"15050484_CR19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1242\/dev.121.2.299","volume":"121","author":"CM Chia","year":"1995","unstructured":"Chia CM, Winston RM, Handyside AH EGF, TGF-alpha and EGFR expression in human preimplantation embryos. Development.1995;121:299\u2013307.","journal-title":"Development"},{"key":"15050484_CR20","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1073\/pnas.0611516104","volume":"104","author":"K Sugihara","year":"2007","unstructured":"Sugihara K, Sugiyama D, Byrne J, et al. Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. Proc Natl Acad Sci U S A. 2007;104: 3799\u20133804.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"15050484_CR21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1242\/dev.120.5.1071","volume":"120","author":"SK Das","year":"1994","unstructured":"Das SK, Wang XN, Paria BC, et al. Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development. 1994;120:1071\u20131083.","journal-title":"Development"},{"key":"15050484_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1073\/pnas.98.3.1047","volume":"98","author":"BC Paria","year":"2001","unstructured":"Paria BC, Ma W., Tan J., et al. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc Natl Acad Sci U S A. 2001; 98:1047\u20131052.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"15050484_CR23","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/(SICI)1520-6408(1997)21:1<102::AID-DVG12>3.0.CO;2-C","volume":"21","author":"HJ Yoo","year":"1997","unstructured":"Yoo HJ, Barlow DH, Mardon HJ. Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: a possible role in blastocyst implantation. Dev Genet. 1997;21: 102\u2013108.","journal-title":"Dev Genet"},{"key":"15050484_CR24","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1210\/endo.135.3.8070372","volume":"135","author":"XN Wang","year":"1994","unstructured":"Wang XN, Das SK, Damm D, et al. Differential regulation of heparin-binding epidermal growth factor-like growth factor in the adult ovariectomized mouse uterus by progesterone and estrogen. Endocrinology. 1994;135:1264\u20131271.","journal-title":"Endocrinology"},{"key":"15050484_CR25","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1095\/biolreprod52.4.928","volume":"52","author":"T Imai","year":"1995","unstructured":"Imai T, Kurachi H, Adachi K, et al. Changes in epidermal growth factor receptor and the levels of its ligands during menstrual cycle in human endometrium. Biol Reprod. 1995; 52:928\u2013938.","journal-title":"Biol Reprod"},{"key":"15050484_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/molehr\/7.1.65","volume":"7","author":"B Moller","year":"2001","unstructured":"Moller B, Ronnerdag M, Wang G, et al. Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle. Mol Hum Reprod. 2001;7:65\u201372.","journal-title":"Mol Hum Reprod"},{"key":"15050484_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/bit.10457","volume":"81","author":"AM Sanden","year":"2003","unstructured":"Sanden AM. Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng. 2003;81: 158\u2013166.","journal-title":"Biotechnol Bioeng"},{"key":"15050484_CR28","first-page":"3263","volume":"87","author":"M Tamura","year":"2002","unstructured":"Tamura M, Sebastian S, Yang S, et al. Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. J Clin Endocrinol Metab. 2002;87:3263\u20133273.","journal-title":"J Clin Endocrinol Metab"},{"key":"15050484_CR29","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1242\/dev.126.9.1997","volume":"126","author":"BC Paria","year":"1999","unstructured":"Paria BC, Elenius K, Klagsbrun M, et al. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparin sulfate proteoglycans and ErbB4 in blastocyst implantation. Development. 1999;126:1997\u20132005.","journal-title":"Development"},{"key":"15050484_CR30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S0046-8177(96)90070-2","volume":"27","author":"H Niikura","year":"1996","unstructured":"Niikura H, Sasano H, Kaga K, et al. Expression of epidermal growth factor family proteins and epidermal growth factor receptor in human endometrium. Hum Pathol. 1996;27:282\u2013289.","journal-title":"Hum Pathol"},{"key":"15050484_CR31","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1210\/en.2006-0231","volume":"147","author":"A Khatua","year":"2006","unstructured":"Khatua A, Wang X, Ding T, et al. Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamsters. Endocrinology. 2006;147: 4079\u20134092.","journal-title":"Endocrinology"},{"key":"15050484_CR32","first-page":"691","volume":"9","author":"SK Das","year":"1995","unstructured":"Das SK, Paria BC, Wang XN, et al. Amphiregulin is an implantation-specific and progesterone regulated gene in the mouse uterus. Mol Endocrinol. 1995;9:691\u2013705.","journal-title":"Mol Endocrinol"},{"key":"15050484_CR33","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0143-4004(95)90093-4","volume":"16","author":"JJ Lysiak","year":"1995","unstructured":"Lysiak JJ, Johnson GR, Lala PK. Localization of amphiregulin in the human placenta and decidua throughout gestation: role in trophoblast growth. Placenta. 1995;16:359\u2013366.","journal-title":"Placenta"},{"key":"15050484_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/359076a0","volume":"359","author":"CL Stewart","year":"1992","unstructured":"Stewart CL, Kaspar P, Brunet LJ, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992;359:76\u201379.","journal-title":"Nature"},{"key":"15050484_CR35","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1210\/endo.135.3.8070371","volume":"135","author":"Z Zhang","year":"1994","unstructured":"Zhang Z, Funk C, Glasser SR, et al. Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299. Endocrinology. 1994;135:1256\u20131263.","journal-title":"Endocrinology"},{"key":"15050484_CR36","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1210\/me.2004-0110","volume":"18","author":"JR Sherwin","year":"2004","unstructured":"Sherwin JR, Freeman TC, Stephens RJ, et al., Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation. Mol Endocrinol. 2004;18:2185\u20132195.","journal-title":"Mol Endocrinol"},{"key":"15050484_CR37","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/mrd.10129","volume":"62","author":"BA Lessey","year":"2002","unstructured":"Lessey BA, Gui Y, Apparao KB, et al. Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation. Mol Reprod Dev. 2002;62:446\u2013455.","journal-title":"Mol Reprod Dev"},{"key":"15050484_CR38","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1093\/humrep\/del135","volume":"21","author":"N Gleicher","year":"2006","unstructured":"Gleicher N, Barad D, Unexplained infertility: does it really exist? Hum Reprod. 2006;21:1951\u20131955.","journal-title":"Hum Reprod"},{"key":"15050484_CR39","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.fertnstert.2004.03.069","volume":"82","author":"C Coutifaris","year":"2004","unstructured":"Coutifaris C, Myers ER, Guzick DS, et al. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril. 2004;82:1264\u20131272.","journal-title":"Fertil Steril"},{"key":"15050484_CR40","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1210\/jcem.87.3.8350","volume":"87","author":"SL Young","year":"2002","unstructured":"Young SL, Lessey BA, Fritz MA, et al. In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor. J Clin Endocrinol Metab. 2002;87:1368\u20131375.","journal-title":"J Clin Endocrinol Metab"},{"key":"15050484_CR41","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0301-5629(96)00197-4","volume":"23","author":"K Sterzik","year":"1997","unstructured":"Sterzik K, Grab D, Schneider V, Strehler EJ, Gagsteiger F, Rosenbusch BE. Lack of correlation between ultrasonography and histologic staging of the endometrium in in vitro fertilization (IVF) patients. Ultrasound Med Biol. 1997;23:165\u2013170.","journal-title":"Ultrasound Med Biol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719108314624.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719108314624\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719108314624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719108314624.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:08:06Z","timestamp":1656810486000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719108314624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["15050484"],"URL":"https:\/\/doi.org\/10.1177\/1933719108314624","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"31 December 2008","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}