{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:33:39Z","timestamp":1790714019881,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1177\/1933719111414205","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T22:43:04Z","timestamp":1321569784000},"page":"1230-1236","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Frequency of Metabolic Syndrome is Higher Among PCOS Brazilian Women With Menstrual Irregularity Plus Hyperandrogenism"],"prefix":"10.1007","volume":"18","author":[{"given":"Anderson Sanches","family":"Melo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Sales","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Gabriel Maltoni","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui A.","family":"Ferriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,30]]},"reference":[{"issue":"12","key":"18121230_CR1","first-page":"3108","volume":"21","author":"C Belosi","year":"2006","unstructured":"Belosi C, Selvaggi L, Apa R, et al. Is the PCOS diagnosis solved by ESHRE\/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma? Hum reprod. 2006;21(12):3108\u20133115.","journal-title":"Is the PCOS diagnosis solved by ESHRE\/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma?"},{"issue":"6","key":"18121230_CR2","first-page":"2493","volume":"94","author":"D Wiltgen","year":"2010","unstructured":"Wiltgen D, Spritzer PM. Variation in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes. Fertil Steril. 2010;94(6):2493\u20132496.","journal-title":"Variation in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes"},{"issue":"3","key":"18121230_CR3","first-page":"710","volume":"24","author":"AJ Goverde","year":"2009","unstructured":"Goverde AJ, van Koert AJ, Eijkemans MJ, et al. Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria. Hum Reprod. 2009;24(3):71\u2013717.","journal-title":"Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria"},{"issue":"4","key":"18121230_CR4","first-page":"477","volume":"15","author":"L Moran","year":"2009","unstructured":"Moran L, Teede H. Metabolic features of the reproductive phenotypes of polycystic ovary syndrome. Hum Reprod. 2009;15(4):477\u2013488.","journal-title":"Metabolic features of the reproductive phenotypes of polycystic ovary syndrome"},{"issue":"6","key":"18121230_CR5","first-page":"1702","volume":"86","author":"A Dokras","year":"2006","unstructured":"Dokras A, Jagasia DH, Maifeld M, Sinkey CA, VanVoorhis BJ, Haynes WG. Obesity and insulin resistance but not hyperandrogenism mediates vascular dysfunction in women with polycystic ovary syndrome. Fertil Steril. 2006;86(6):1702\u20131709.","journal-title":"Obesity and insulin resistance but not hyperandrogenism mediates vascular dysfunction in women with polycystic ovary syndrome"},{"issue":"suppl 1","key":"18121230_CR6","first-page":"S4","volume":"86","author":"F de Zegher","year":"2006","unstructured":"de Zegher F, Ibanez L. Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome. Fertil Steril. 2006;86(suppl 1):S4\u2013S5.","journal-title":"Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome"},{"issue":"10","key":"18121230_CR7","first-page":"1210","volume":"113","author":"FJ Broekmans","year":"2006","unstructured":"Broekmans FJ, Knauff EA, Valkenburg O, Laven JS, Eijkemans MJ, Fauser BC. PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG. 2006;113(10):1210\u20131217.","journal-title":"PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors"},{"issue":"10","key":"18121230_CR8","first-page":"3922","volume":"91","author":"D Dewailly","year":"2006","unstructured":"Dewailly D, Catteau-Jonard S, Reyss AC, Leroy M, Pigny P. Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. J Clin Endocrinol Metab. 2006;91(10):3922\u20133927.","journal-title":"Oligoanovulation with polycystic ovaries but not overt hyperandrogenism"},{"key":"18121230_CR9","first-page":"e1","volume":"670","author":"RP Kauffman","year":"2008","unstructured":"Kauffman RP, Baker TE, Baker VM, DiMarino P, Castracane VD. Endocrine and metabolic differences among phenotypic expressions of polycystic ovary syndrome according to the 2003 Rotterdam consensus criteria. Am J Obstet Gynecol. 2008;198(6):670.e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"17","key":"18121230_CR10","first-page":"2735","volume":"112","author":"SM Grundy","year":"2005","unstructured":"Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735\u20132752.","journal-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart"},{"issue":"12","key":"18121230_CR11","first-page":"4842","volume":"91","author":"CK Welt","year":"2006","unstructured":"Welt CK, Gudmundsson JA, Arason G, et al. Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab. 2006;91(12):4842\u20134848.","journal-title":"Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features"},{"issue":"12","key":"18121230_CR12","first-page":"1633","volume":"116","author":"HY Zhang","year":"2009","unstructured":"Zhang HY, Zhu FF, Xiong J, Shi XB, Fu SX. Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population. BJOG. 2009;116(12):1633\u20131639.","journal-title":"Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population"},{"issue":"1","key":"18121230_CR13","first-page":"141","volume":"154","author":"E Carmina","year":"2006","unstructured":"Carmina E, Napoli N, Longo RA, Rini GB, Lobo RA. Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in the USA and the influence of criteria for the diagnosis of PCOS. Eur J Endocrinol. 2006;154(1):141\u2013145.","journal-title":"Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in the USA and the influence of criteria for the diagnosis of PCOS"},{"issue":"3","key":"18121230_CR14","first-page":"649","volume":"89","author":"EM Soares","year":"2008","unstructured":"Soares EM, Azevedo GD, Gadelha RG, Lemos TM, Maranh\u00e3o TM. Prevalence of the metabolic syndrome and its components in Brazilian women with polycystic ovary syndrome. Fertil Steril. 2008;89(3):649\u2013655.","journal-title":"Prevalence of the metabolic syndrome and its components in Brazilian women with polycystic ovary syndrome"},{"issue":"4","key":"18121230_CR15","first-page":"572","volume":"21","author":"M Guo","year":"2010","unstructured":"Guo M, Chen ZJ, Macklon NS, et al. Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reprod Biomed Online. 2010;21(4):572\u2013580.","journal-title":"Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria"},{"issue":"1","key":"18121230_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/humrep\/deh098","volume":"19","author":"The Rotterdam ESHRE\/ASRM\u2014Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"The Rotterdam ESHRE\/ASRM\u2014Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u201347.","journal-title":"Hum Reprod"},{"key":"18121230_CR17","first-page":"1440","volume":"21","author":"D Ferriman","year":"1961","unstructured":"Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;21:1440\u20131447.","journal-title":"Clinical assessment of body hair growth in women"},{"issue":"6","key":"18121230_CR18","first-page":"499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy IR, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499\u2013502.","journal-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge"},{"issue":"17","key":"18121230_CR19","first-page":"2735","volume":"112","author":"SM Grundy","year":"2005","unstructured":"Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and Management of the Metabolic Syndrome An American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735\u20132752.","journal-title":"Diagnosis and Management of the Metabolic Syndrome An American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement"},{"issue":"5","key":"18121230_CR20","first-page":"536","volume":"84","author":"IJ Griffin","year":"1995","unstructured":"Griffin IJ, Cole TJ, Duncan KA, Hollman AS, Donaldson MD. Pelvic ultrasound measurements in normal girls. Acta Paediatr. 1995;84(5):536\u2013543.","journal-title":"Pelvic ultrasound measurements in normal girls"},{"issue":"9","key":"18121230_CR21","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.2337\/diacare.28.9.2289","volume":"28","author":"R Kahn","year":"2005","unstructured":"Kahn R, Buse J, Ferrannini E, Stern M; American Diabetes Association; European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2005;28(9):2289\u20132304.","journal-title":"Diabetes Care"},{"issue":"7","key":"18121230_CR22","first-page":"412","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412\u2013419.","journal-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man"},{"issue":"2","key":"18121230_CR23","first-page":"219","volume":"72","author":"B Geloneze","year":"2006","unstructured":"Geloneze B, Repetto EM, Geloneze SR, Tambascia MA, Ermetice MN. The threshold value for insulin resistance (HOMA-IR) in an admixtured population IR in the Brazilian Metabolic Syndrome Study. Diabetes Res Clin Pract. 2006;72(2):219\u2013220.","journal-title":"The threshold value for insulin resistance (HOMA-IR) in an admixtured population IR in the Brazilian Metabolic Syndrome Study"},{"issue":"7","key":"18121230_CR24","first-page":"908","volume":"52","author":"CJ Glueck","year":"2003","unstructured":"Glueck CJ, Papanna R, Wang P, Goldenberg N, Sieve-Smith L. Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism. 2003;52(7):908\u2013915.","journal-title":"Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome"},{"issue":"4","key":"18121230_CR25","first-page":"1929","volume":"90","author":"T Apridonidze","year":"2005","unstructured":"Apridonidze T, Essah P, Iuorno M, Nestler JE. Prevalence and characteristics of metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90(4):1929\u20131935.","journal-title":"Prevalence and characteristics of metabolic syndrome in women with polycystic ovary syndrome"},{"issue":"3","key":"18121230_CR26","first-page":"661","volume":"82","author":"E Carmina","year":"2004","unstructured":"Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004;82(3):661\u2013665.","journal-title":"Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome"},{"issue":"8","key":"18121230_CR27","first-page":"2124","volume":"25","author":"AS Melo","year":"2010","unstructured":"Melo AS, Vieira CS, Barbieri MA, et al. High prevalence of polycystic ovary syndrome in women born small for gestational age. Hum Reprod. 2010;25(8):2124\u20132131.","journal-title":"High prevalence of polycystic ovary syndrome in women born small for gestational age"},{"issue":"25","key":"18121230_CR28","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","volume":"106","author":"Third Report of the National Cholesterol Education Program (NCEP)","year":"2002","unstructured":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143\u20133421.","journal-title":"Circulation"},{"issue":"3","key":"18121230_CR29","first-page":"356","volume":"287","author":"ES Ford","year":"2002","unstructured":"Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA. 2002;287(3):356\u2013359.","journal-title":"Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey"},{"issue":"1","key":"18121230_CR30","first-page":"48","volume":"91","author":"DA Ehrmann","year":"2006","unstructured":"Ehrmann DA, Liljenquist DR, Kasza K, et al. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91(1):48\u201353.","journal-title":"Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome"},{"issue":"3","key":"18121230_CR31","first-page":"406","volume":"71","author":"GM Soares","year":"2009","unstructured":"Soares GM, Vieira CS, Martins WP, et al. Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? Clin Endocrinol (Oxf). 2009;71(3):406\u2013411.","journal-title":"Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome?"},{"issue":"10","key":"18121230_CR32","first-page":"736","volume":"26","author":"C Castelo-Branco","year":"2010","unstructured":"Castelo-Branco C, Steinvarcel F, Osorio A, Ros C, Balasch J. Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol. 2010;26(10):736\u2013742.","journal-title":"Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism"},{"issue":"5","key":"18121230_CR33","first-page":"1319","volume":"85","author":"R Pasquali","year":"2006","unstructured":"Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril. 2006;85(5):1319\u20131340.","journal-title":"Obesity and androgens: facts and perspectives"},{"issue":"5","key":"18121230_CR34","first-page":"2038","volume":"95","author":"RA Wild","year":"2010","unstructured":"Wild RA, Carmina E, Diamanti-Kandarakis E, et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab. 2010;95(5):2038\u20132049.","journal-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society"},{"issue":"3","key":"18121230_CR35","first-page":"556","volume":"16","author":"MW Elting","year":"2001","unstructured":"Elting MW, Korsen TJM, Bezemer PD, Schoemaker J. Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population. Hum Reprod. 2001;16(3):556\u2013560.","journal-title":"Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population"},{"issue":"4","key":"18121230_CR36","first-page":"347","volume":"16","author":"LJ Moran","year":"2010","unstructured":"Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2010;16(4):347\u2013363.","journal-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis"},{"issue":"1","key":"18121230_CR37","first-page":"2402","volume":"85","author":"RA De Fronzo","year":"1979","unstructured":"DeFronzo RA, Tobin JD, Andreas R. Glucose clamp technique: a method for quantifying insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 1979;85(1):2402\u20132410.","journal-title":"Glucose clamp technique: a method for quantifying insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans"},{"issue":"8","key":"18121230_CR38","first-page":"480","volume":"10","author":"M Straczkowski","year":"2004","unstructured":"Straczkowski M, Stepie\u0144 A, Kowalska I, Kinalska I. Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp technique. Med Sci Monit. 2004; 10(8):480\u2013484.","journal-title":"Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp technique"},{"issue":"3","key":"18121230_CR39","first-page":"189","volume":"37","author":"Z Radikova","year":"2003","unstructured":"Radikova Z. Assessment of insulin sensitivity\/resistance in epidemiological studies. Endocr Regul. 2003;37(3):189\u2013194.","journal-title":"Assessment of insulin sensitivity\/resistance in epidemiological studies"},{"issue":"2","key":"18121230_CR40","first-page":"405","volume":"92","author":"W Rosner","year":"2007","unstructured":"Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H. Utility, limitation, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab. 2007;92(2):405\u2013413.","journal-title":"Utility, limitation, and pitfalls in measuring testosterone: an Endocrine Society position statement"},{"issue":"12","key":"18121230_CR41","first-page":"5305","volume":"95","author":"RS Legro","year":"2010","unstructured":"Legro RS, Schlaff WD, Diamond MP, et al. Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. J Clin Endocrinol Metab. 2010;95(12):5305\u20135313.","journal-title":"Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism"},{"issue":"6","key":"18121230_CR42","first-page":"505","volume":"9","author":"AH Balen","year":"2003","unstructured":"Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003;9(6):505\u2013514.","journal-title":"Ultrasound assessment of the polycystic ovary: international consensus definitions"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111414205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719111414205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719111414205\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719111414205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111414205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:19:06Z","timestamp":1656811146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719111414205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["18121230"],"URL":"https:\/\/doi.org\/10.1177\/1933719111414205","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"30 December 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}