{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:05:54Z","timestamp":1770739554237,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1177\/1933719111415548","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T18:24:11Z","timestamp":1319653451000},"page":"1046-1070","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Biomarkers of Spontaneous Preterm Birth: An Overview of The Literature in the Last Four Decades"],"prefix":"10.1007","volume":"18","author":[{"given":"Ramkumar","family":"Menon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Regina","family":"Torloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Voltolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Torricelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Merialdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Pilar","family":"Betr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Davydova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulfiya","family":"Khodjaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul","family":"Thorsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Kacerovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojt\u00ecch","family":"Tambor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tytti","family":"Massinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Nace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chander","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,30]]},"reference":[{"issue":"6","key":"18111046_CR1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/00016340802005126","volume":"87","author":"R Menon","year":"2008","unstructured":"Menon R. Spontaneous preterm birth, a clinical dilemma: etiolo-gic, pathophysiologic and genetic heterogeneities and racial disparity. Acta Obstet Gynecol Scand. 2008;87(6):590\u2013600.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"18111046_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/aje\/154.4.307","volume":"154","author":"K Demissie","year":"2001","unstructured":"Demissie K, Rhoads GG, Ananth CV, et al. Trends in preterm birth and neonatal mortality among blacks and whites in the United States from 1989 to 1997 Am J Epidemiol. 2001;154(4): 307\u2013315.","journal-title":"Am J Epidemiol"},{"issue":"11","key":"18111046_CR3","first-page":"1516","volume":"97","author":"K Fiscella","year":"2005","unstructured":"Fiscella K. Race, genes and preterm delivery. J Natl Med Assoc. 2005;97(11):1516\u20131526.","journal-title":"J Natl Med Assoc."},{"key":"18111046_CR4","unstructured":"Committee on Understanding Premature Birth and Assuring Healthy Outcomes. In: Berhman RE, Butler AS, eds. Preterm Birth: Causes, Consequences and Prevention. Washington DC, The National Academies Press; 2006. Ref Type: Serial (Book, Monograph)."},{"key":"18111046_CR5","unstructured":"March of Dimes. Preterm Births Rise 36 Percent Since Early 1980s. (2009);9-12-2010. Ref Type: Online Source."},{"issue":"1","key":"18111046_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2471\/BLT.08.062554","volume":"88","author":"S Beck","year":"2010","unstructured":"Beck S, Wojdyla D, Say L, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010;88(1):31\u201338.","journal-title":"Bull World Health Organ"},{"issue":"1","key":"18111046_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0029-7844(98)00067-2","volume":"92","author":"G Faron","year":"1998","unstructured":"Faron G, Boulvain M, Irion O, Bernard PM, Fraser WD. Prediction of preterm delivery by fetal fibronectin: a meta-analysis. Obstet Gynecol. 1998;92(1):153\u2013158.","journal-title":"Obstet Gynecol"},{"issue":"7359","key":"18111046_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1136\/bmj.325.7359.301","volume":"325","author":"H Honest","year":"2002","unstructured":"Honest H, Bachmann LM, Gupta JK, Kleijnen J, Khan KS. Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review. BMJ. 2002;325(7359):301.","journal-title":"BMJ"},{"issue":"3","key":"18111046_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/uog.202","volume":"22","author":"H Honest","year":"2003","unstructured":"Honest H, Bachmann LM, Coomarasamy A, Gupta JK, Kleijnen J, Khan KS. Accuracy of cervical transvaginal sonography in predicting preterm birth: a systematic review. Ultrasound Obstet Gynecol. 2003;22(3):305\u2013322.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"18111046_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/uog.1062","volume":"24","author":"H Honest","year":"2004","unstructured":"Honest H, Bachmann LM, Sengupta R, Gupta JK, Kleijnen J, Khan KS. Accuracy of absence of fetal breathing movements in predicting preterm birth: a systematic review. Ultrasound Obstet Gynecol. 2004;24(1):94\u2013100.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"18111046_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/01443610410001685439","volume":"24","author":"H Honest","year":"2004","unstructured":"Honest H, Bachmann LM, Sundaram R, Gupta JK, Kleijnen J, Khan KS. The accuracy of risk scores in predicting preterm birth-a systematic review J Obstet Gynaecol. 2004;24(4): 343\u2013359.","journal-title":"J Obstet Gynaecol"},{"issue":"5","key":"18111046_CR12","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1471-0528.2004.00124.x","volume":"111","author":"H Honest","year":"2004","unstructured":"Honest H, Bachmann LM, Knox EM, Gupta JK, Kleijnen J, Khan KS. The accuracy of various tests for bacterial vaginosis in predicting preterm birth: a systematic review BJOG. 2004;111(5): 409\u2013422.","journal-title":"BJOG"},{"issue":"6","key":"18111046_CR13","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1067\/mob.2000.106855","volume":"182","author":"EL Mozurkewich","year":"2000","unstructured":"Mozurkewich EL, Naglie G, Krahn MD, Hayashi RH. Predicting preterm birth: a cost-effectiveness analysis. Am J Obstet Gynecol. 2000;182(6):1589\u20131598.","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"18111046_CR14","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/j.1471-0528.2007.01385.x","volume":"114","author":"RD Trochez-Martinez","year":"2007","unstructured":"Trochez-Martinez RD, Smith P, Lamont RF. Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. BJOG. 2007;114(7):796\u2013801.","journal-title":"BJOG"},{"issue":"1","key":"18111046_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ejogrb.2009.04.017","volume":"145","author":"W Yuan","year":"2009","unstructured":"Yuan W, Chen L, Bernal AL. Is elevated maternal serum alpha-fetoprotein in the second trimester of pregnancy associated with increased preterm birth risk? A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2009;145(1):57\u201364.","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"issue":"7305","key":"18111046_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/bmj.323.7305.157","volume":"323","author":"JJ Deeks","year":"2001","unstructured":"Deeks JJ. Systematic reviews in health care: systematic reviews of evaluations of diagnostic and screening tests. BMJ. 2001;323(7305):157\u2013162.","journal-title":"BMJ"},{"issue":"8","key":"18111046_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.7326\/0003-4819-120-8-199404150-00008","volume":"120","author":"L Irwig","year":"1994","unstructured":"Irwig L, Tosteson AN, Gatsonis C, et al. Guidelines for metaanalyses evaluating diagnostic tests Ann Intern Med. 1994;120(8): 667\u2013676.","journal-title":"Ann Intern Med."},{"issue":"1","key":"18111046_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0301-2115(00)00463-2","volume":"95","author":"KS Khan","year":"2001","unstructured":"Khan KS, Dinnes J, Kleijnen J. Systematic reviews to evaluate diagnostic tests Eur J Obstet Gynecol Reprod Biol. 2001;95(1): 6\u201311.","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"18111046_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2288-3-25","volume":"3","author":"P Whiting","year":"2003","unstructured":"Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25.","journal-title":"BMC Med Res Methodol"},{"issue":"4","key":"18111046_CR20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/OGX.0b013e3181dbc55b","volume":"65","author":"LM Bodnar","year":"2010","unstructured":"Bodnar LM, Simhan HN. Vitamin D may be a link to black-white disparities in adverse birth outcomes. Obstet Gynecol Surv. 2010;65(4):273\u2013284.","journal-title":"Obstet Gynecol Surv."},{"issue":"2","key":"18111046_CR21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1600-0897.2006.00394.x","volume":"56","author":"R Menon","year":"2006","unstructured":"Menon R, Merialdi M, Lombardi SJ, Fortunato SJ. Differences in the placental membrane cytokine response: a possible explanation for the racial disparity in preterm birth. Am J Reprod Immunol. 2006;56(2):112\u2013118.","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"18111046_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/1933719107301336","volume":"14","author":"R Menon","year":"2007","unstructured":"Menon R, Williams SM, Fortunato SJ. Amniotic fluid interleukin-1beta and interleukin-8 concentrations: racial disparity in preterm birth. Reprod Sci. 2007;14(3):253\u2013259.","journal-title":"Reprod Sci."},{"issue":"5","key":"18111046_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ajog.2007.11.025","volume":"198","author":"R Menon","year":"2008","unstructured":"Menon R, Camargo MC, Thorsen P, Lombardi SJ, Fortunato SJ. Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans. Am J Obstetr Gynecol. 2008;198(5):77.","journal-title":"Am J Obstetr Gynecol"},{"issue":"5","key":"18111046_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ajog.2007.11.025","volume":"198","author":"R Menon","year":"2008","unstructured":"Menon R, Thorsen P, Vogel I, et al. Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-(alpha) and soluble TNF receptors in spontaneous preterm birth. Am J Obstetr Gynecol. 2008;198(5):533.","journal-title":"Am J Obstetr Gynecol"},{"issue":"2","key":"18111046_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jri.2008.11.003","volume":"79","author":"KK Ryckman","year":"2009","unstructured":"Ryckman KK, Simhan HN, Krohn MA, Williams SM. Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry. J Reprod Immunol. 2009;79(2):174\u2013182.","journal-title":"J Reprod Immunol"},{"issue":"12","key":"18111046_CR26","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.3109\/00016340903410873","volume":"88","author":"A Tsourapas","year":"2009","unstructured":"Tsourapas A, Roberts TE, Barton PM, et al. An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies. Acta Obstet Gynecol Scand. 2009;88(12):1319\u20131330.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"10","key":"18111046_CR27","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/S1701-2163(16)32973-5","volume":"30","author":"A Gagnon","year":"2008","unstructured":"Gagnon A, Wilson RD, Audibert F, et al. Obstetrical complications associated with abnormal maternal serum markers analytes. J Obstet Gynaecol Can. 2008;30(10):918\u2013949.","journal-title":"J Obstet Gynaecol Can"},{"issue":"43","key":"18111046_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta13430","volume":"13","author":"H Honest","year":"2009","unstructured":"Honest H, Forbes CA, Duree KH, et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess. 2009;13(43):1\u2013627.","journal-title":"Health Technol Assess."},{"issue":"2 pt 1","key":"18111046_CR29","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/AOG.0b013e3181e6dbc0","volume":"116","author":"SQ Wei","year":"2010","unstructured":"Wei SQ, Fraser W, Luo ZC. Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review. Obstet Gynecol. 2010;116(2 pt 1):393\u2013401.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"18111046_CR30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1080\/00016340802702219","volume":"88","author":"AE Curry","year":"2009","unstructured":"Curry AE, Thorsen P, Drews C, et al. First-trimester maternal plasma cytokine levels, pre-pregnancy body mass index, and spontaneous preterm delivery. Acta Obstet Gynecol Scand. 2009;88(3):332\u2013342.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"18111046_CR31","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jri.2008.08.006","volume":"79","author":"JW Gargano","year":"2008","unstructured":"Gargano JW, Holzman C, Senagore P, et al. Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth J Reprod Immunol. 2008;79(1): 100\u2013110.","journal-title":"J Reprod Immunol"},{"issue":"2 pt 1","key":"18111046_CR32","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/AOG.0b013e3181ae6a08","volume":"114","author":"RM Holst","year":"2009","unstructured":"Holst RM, Hagberg H, Wennerholm UB, Skogstrand K, Thorsen P, Jacobsson B. Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids. Obstet Gynecol. 2009;114(2 pt 1):268\u2013277.","journal-title":"Obstet Gynecol"},{"issue":"5","key":"18111046_CR33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/14767050802609759","volume":"22","author":"K Mestan","year":"2009","unstructured":"Mestan K, Yu Y, Thorsen P, et al. Cord blood biomarkers of the fetal inflammatory response. J Matern Fetal Neonatal Med. 2009;22(5):379\u2013387.","journal-title":"J Matern Fetal Neonatal Med."},{"issue":"5","key":"18111046_CR34","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1097\/AOG.0b013e31817057fb","volume":"111","author":"K Skogstrand","year":"2008","unstructured":"Skogstrand K, Hougaard DM, Schendel DE, Bent NP, Svaerke C, Thorsen P. Association of preterm birth with sustained postnatal inflammatory response Obstet Gynecol. 2008;111(5): 1118\u20131128.","journal-title":"Obstet Gynecol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111415548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719111415548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719111415548\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719111415548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111415548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:17:51Z","timestamp":1656811071000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719111415548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["18111046"],"URL":"https:\/\/doi.org\/10.1177\/1933719111415548","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"30 December 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}