{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:50:59Z","timestamp":1778673059416,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1177\/1933719111426605","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T02:19:42Z","timestamp":1327112382000},"page":"534-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trichosanthin, a Chinese Medicine for the Medical Treatment of Ectopic Pregnancy With High Levels of \u03b2-hCG"],"prefix":"10.1007","volume":"19","author":[{"given":"D. J.","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,12,30]]},"reference":[{"key":"1905534_CR1","unstructured":"Anon, Ectopic pregnancies: United States, 1990\u20131992, MMWR Morb Mortal Wkly Rep 44. 1995, 46\u201348."},{"issue":"7147","key":"1905534_CR2","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1136\/bmj.316.7147.1776","volume":"316","author":"M Egger","year":"1998","unstructured":"Egger M, Low N, Smith GD, Lindblom B, Herrmann B. Screening for chlamydial infections and the risk of ectopic pregnancy in a county in Sweden: ecological analysis, BMJ. 1998;316(7147):1776\u20131786.","journal-title":"BMJ"},{"key":"1905534_CR3","volume-title":"Why Mothers die 1997\u20131999: the Fifth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom 1997\u20131999","author":"RCOG","year":"2001","unstructured":"RCOG. Why Mothers die 1997\u20131999: the Fifth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom 1997\u20131999. London, UK: RCOG Press; 2001."},{"issue":"18","key":"1905534_CR4","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1056\/NEJM200011023431807","volume":"343","author":"GH Lipscomb","year":"2000","unstructured":"Lipscomb GH, Stovall TG, Ling FW. Nonsurgical treatment of ectopic pregnancy. N Engl J Med. 2000;343(18):1325\u20131329.","journal-title":"N Engl J Med"},{"issue":"6","key":"1905534_CR5","first-page":"S96","volume":"86","author":"American Society for Reproductive Medicine","year":"2006","unstructured":"American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: the practice committee of the American society for reproductive medicine. Fertil Steril. 2006;86(6):S96\u2013S102.","journal-title":"Fertil Steril"},{"issue":"9485","key":"1905534_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0140-6736(05)67103-6","volume":"66","author":"CM Farquhar","year":"2005","unstructured":"Farquhar CM. Ectopic pregnancy. Lancet. 2005;66(9485):583\u2013591.","journal-title":"Lancet"},{"issue":"6 pt 1","key":"1905534_CR7","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1016\/0002-9378(93)90687-E","volume":"68","author":"TG Stovall","year":"1993","unstructured":"Stovall TG, Ling FW. Single dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol. 1993;68(6 pt 1):1759\u20131765.","journal-title":"Am J Obstet Gynecol"},{"key":"1905534_CR8","volume-title":"Medical Management of Ectopic Pregnancy: ACOG Practice Bulletin no","author":"DL Fylstra","year":"2008","unstructured":"Fylstra DL. Medical Management of Ectopic Pregnancy: ACOG Practice Bulletin no. 94. Washington, DC: American College of Obstetricians and Gynecologists; 2008."},{"issue":"1","key":"1905534_CR9","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/j.1460-2075.1989.tb03377.x","volume":"8","author":"MJ May","year":"1989","unstructured":"May MJ, Hartley MR, Roberts LM, Krieg PA, Osborn RW, Lord JM. Ribosome inactivation by ricin a chain: a sensitive method to assess the activity of wild-type and mutant polypeptides. EMBO J. 1989;8(1):301\u2013308.","journal-title":"EMBO J"},{"issue":"24","key":"1905534_CR10","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1016\/S0021-9258(18)60855-5","volume":"262","author":"JM Maraganore","year":"1987","unstructured":"Maraganore JM, Joseph M, Bailey MC. Purification and characterization of TCS. Homology to the ricin a chain and mplications as to mechanism of abortifacient activity. J Biol Chem. 1987;262(24):11628\u201311633.","journal-title":"J Biol Chem"},{"issue":"3","key":"1905534_CR11","first-page":"46","volume":"11","author":"Liu Shu-Lian","year":"1991","unstructured":"Liu Shu-Lian, Wu Xu-Dong, Liu Guo-Wu, et al. Primary study on safety of trichosanthin combined with reserpine and testosterone propionate for termination of early & middle stage pregnancy: a clinical report of 7754 cases [In Chinese]. Reprod Contraception. 1991;11(3):46\u201351.","journal-title":"Reprod Contraception"},{"issue":"1","key":"1905534_CR12","first-page":"34","volume":"10","author":"YC Jin","year":"1990","unstructured":"Jin YC. Crystal trichosanthin protein intramuscular or intracervical injection for the termination of pregnancy at 10 to 14 weeks gestation: clinical analysis of 200 cases [In Chinese]. Reprod Contraception. 1990;10(1):34\u201337.","journal-title":"Reprod Contraception"},{"issue":"4","key":"1905534_CR13","first-page":"411","volume":"26","author":"RX Dai","year":"1993","unstructured":"Dai RX, Xu GJ, Lin XY, et al. Studies on injury-mechanism of trichosanthin on trophoblast cells and choriocarcinoma cells in culture [In Chinese]. Acta Biologiae Experimentalis Sinica. 1993;26(4):411\u2013427.","journal-title":"Acta Biologiae Experimentalis Sinica"},{"issue":"12","key":"1905534_CR14","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1097\/00002030-199012000-00003","volume":"4","author":"JO Kahn","year":"1990","unstructured":"Kahn JO, Kaplan LD, Gambertoglio JG, et al. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. AIDS. 1990;4(12):1197\u20131204.","journal-title":"AIDS"},{"issue":"2","key":"1905534_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1365-2362.1992.tb01944.x","volume":"22","author":"RA Mayer","year":"1992","unstructured":"Mayer RA, Sergios PA, Coonan K, O\u2019Brien L. Trichosanthin treatment of HIV-induced immune dysregulation. Eur J Clin Invest. 1992;22(2):113\u2013122.","journal-title":"Eur J Clin Invest"},{"issue":"12","key":"1905534_CR16","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/00002030-199012000-00002","volume":"4","author":"VS Byers","year":"1990","unstructured":"Byers VS, Levin AS, Waites LA, et al. A phase I\/II study of trichosanthin treatment of HIV disease. AIDS. 1990;4(12):1189\u20131196.","journal-title":"AIDS"},{"issue":"5","key":"1905534_CR17","first-page":"7","volume":"14","author":"HZ Jiang","year":"1992","unstructured":"Jiang HZ, Zhou ZM. Crystal trichosanthin treatment of Ectopic pregnancy: a clinnical report of 26 cases [In Chinese]. Hubei J Tradit Chin Med. 1992;14(5):7\u20138.","journal-title":"Hubei J Tradit Chin Med"},{"issue":"5","key":"1905534_CR18","first-page":"365","volume":"102","author":"PX Lu","year":"1989","unstructured":"Lu PX, Jin YC. Ectopic pregnancy treated with trichosanthin. Clinical analysis of 71 patients. Chin Med J (Engl). 1989;102(5):365\u2013367.","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"1905534_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000293116","volume":"31","author":"C Egarter","year":"1991","unstructured":"Egarter C, Husslein P, Yeung HW. Trichosanthin injection in tubal pregnancy. Gynecol Obstet Invest. 1991;31(2):119\u2013120.","journal-title":"Gynecol Obstet Invest"},{"issue":"3","key":"1905534_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0015-0282(16)60549-6","volume":"51","author":"TG Stovall","year":"1989","unstructured":"Stovall TG, Ling FW, Buster JE. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril. 1989;51(3):435\u2013438.","journal-title":"Fertil Steril"},{"issue":"4","key":"1905534_CR21","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00404-003-0543-4","volume":"270","author":"M Erdem","year":"2004","unstructured":"Erdem M, Erdem A, Arslan M, O\u00e7 A, Bibero\u011flu K, G\u00fcrsoy R. Single-dose methotrexate for the treatment of unruptured ectopic pregnancy. Arch Gynecol Obstet. 2004;270(4):201\u2013204.","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"1905534_CR22","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0015-0282(97)80064-7","volume":"67","author":"M Yao","year":"1997","unstructured":"Yao M, Tulandi T. Current status of surgical and nonsurgical management of ectopic pregnancy. Fertil Steril. 1997;67(3):421\u2013433.","journal-title":"Fertil Steril"},{"issue":"3","key":"1905534_CR23","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/humrep\/12.3.596","volume":"12","author":"K Clasen","year":"1997","unstructured":"Clasen K, Camus M, Tournaye H, Devroey P. Ectopic pregnancy: let\u2019s cut! strict laparoscopic approach to 194 consecutive cases and review of literature on alternatives. Hum Reprod. 1997;12(3):596\u2013601.","journal-title":"Hum Reprod"},{"issue":"6","key":"1905534_CR24","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1016\/S0002-9378(96)70219-3","volume":"174","author":"CS Stika","year":"1996","unstructured":"Stika CS, Anderson L, Frederiksen MC. Single-dose methotrexate for the treatment of ectopic pregnancy: Northwestern memorial hospital three-year experience. Am J Obstet Gynecol. 1996;174(6):1840\u20131848.","journal-title":"Am J Obstet Gynecol"},{"issue":"5 pt 1","key":"1905534_CR25","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1097\/01.AOG.0000142712.80407.fd","volume":"104","author":"K Barnhart","year":"2004","unstructured":"Barnhart K, Sammel MD, Chung K, Zhou L, Hummel AC, Guo W. Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curve. Obstet Gynecol. 2004;104(5 pt 1):975\u2013981.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"1905534_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1055\/s-2006-934097","volume":"23","author":"N Gabbur","year":"2006","unstructured":"Gabbur N, Sherer DM, Hellmann M, Abdelmalek E, Phillip P, Abulafia O. Do serum beta-human chorionic gonadotropin levels on day 4 following methotrexate treatment of patients with ectopic pregnancy predict successful single-dose therapy? Am J Perinatol. 2006;23(3):193\u2013196.","journal-title":"Am J Perinatol"},{"issue":"6","key":"1905534_CR27","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/uog.1061","volume":"23","author":"J Elson","year":"2004","unstructured":"Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D. Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol. 2004;23(6):552\u2013556.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"1905534_CR28","first-page":"778","volume":"101","author":"KT Barnhart","year":"2003","unstructured":"Barnhart KT, Gosman G, Ashby R. Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing \u2018single dose\u2019 and \u2018multidose\u2019 regimens. Obstet Gynecol. 2003;101(4):778\u2013784.","journal-title":"Obstet Gynecol"},{"issue":"6","key":"1905534_CR29","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.toxicon.2004.12.024","volume":"45","author":"PC Shaw","year":"2005","unstructured":"Shaw PC, Lee KM, Wong KB. Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties. Toxicon. 2005;45(6):683\u2013689.","journal-title":"Toxicon"},{"issue":"2","key":"1905534_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0014-5793(02)03539-1","volume":"531","author":"JH Wang","year":"2002","unstructured":"Wang JH, Nie HL, Tarn SC, Huang H, Zheng YT. Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett. 2002;531(2):295\u2013298.","journal-title":"FEBS Lett"},{"issue":"4","key":"1905534_CR31","first-page":"494","volume":"59","author":"KF Cheng","year":"1982","unstructured":"Cheng KF. Midtrimester abortion induced by radix trichosanthis: morphologic observations in placenta and fetus. Obstet Gynecol. 1982;59(4):494\u2013498.","journal-title":"Obstet Gynecol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111426605.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719111426605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719111426605\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719111426605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719111426605.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:22:10Z","timestamp":1656811330000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719111426605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["1905534"],"URL":"https:\/\/doi.org\/10.1177\/1933719111426605","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"30 December 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}