{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:57Z","timestamp":1777909317412,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1177\/1933719112466311","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T01:59:08Z","timestamp":1356573548000},"page":"797-803","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Environmental Factors in the First Trimester and Risk of Oral-Facial Clefts in the Offspring"],"prefix":"10.1007","volume":"20","author":[{"given":"Man-Kin","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence T.","family":"Lao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen-Ha","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak-Yeung","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Kin","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Wai","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"issue":"9703","key":"2007797_CR1","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","volume":"374","author":"PA Mossey","year":"2009","unstructured":"Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. Lancet. 2009;374(9703):1773\u20131785.","journal-title":"Lancet"},{"issue":"4","key":"2007797_CR2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1597\/02-142.1","volume":"41","author":"J Little","year":"2004","unstructured":"Little J, Cardy A, Arslan MT, Gilmour M, Mossey PA. Smoking and orofacial clefts: a United Kingdom-based case-control study. Cleft Palate Craniofac J. 2004;41(4):381\u2013386.","journal-title":"Cleft Palate Craniofac J"},{"issue":"7","key":"2007797_CR3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/aje\/kwm146","volume":"166","author":"PA Romitti","year":"2007","unstructured":"Romitti PA, Sun L, Honein MA, Reefhuis J, Correa A, Rasmussen SA. Maternal periconceptional alcohol consumption and risk of orofacial clefts. Am J Epidemiol. 2007;166(7):775\u2013785.","journal-title":"Am J Epidemiol"},{"issue":"7","key":"2007797_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/bdra.10057","volume":"67","author":"KA Meyer","year":"2003","unstructured":"Meyer KA, Werler MM, Hayes C, Mitchell AA. Low maternal alcohol consumption during pregnancy and oral clefts in offspring: the Slone Birth Defects Study. Birth Defects Res A Clin Mol Teratol. 2003;67(7):509\u2013514.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"5","key":"2007797_CR5","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1597\/05-167","volume":"43","author":"ME Cooper","year":"2006","unstructured":"Cooper ME, Ratay JS, Marazita ML. Asian oral-facial cleft birth prevalence. Cleft Palate Craniofac J. 2006;43(5):580\u2013589.","journal-title":"Cleft Palate Craniofac J"},{"issue":"1","key":"2007797_CR6","first-page":"33","volume":"25","author":"MA Coupland","year":"1988","unstructured":"Coupland MA, Coupland AI. Seasonality, incidence, and sex distribution of cleft lip and palate births in Trent Region, 1973\u20131982. Cleft Palate J. 1988;25(1):33\u201337.","journal-title":"Cleft Palate J"},{"issue":"2","key":"2007797_CR7","first-page":"121","volume":"28","author":"A De la Vega","year":"2009","unstructured":"De la Vega A, Lopez-Cepero R. Seasonal variations in the incidence of some congenital anomalies in Puerto Rico based on the timing of conception. P R Health Sci J. 2009;28(2): 121\u2013125.","journal-title":"P R Health Sci J"},{"issue":"5","key":"2007797_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1597\/07-086.1","volume":"45","author":"RF Elliott","year":"2008","unstructured":"Elliott RF, Jovic G, Beveridge M. Seasonal variation and regional distribution of cleft lip and palate in Zambia. Cleft Palate Craniofac J. 2008;45(5):533\u2013538.","journal-title":"Cleft Palate Craniofac J"},{"issue":"2","key":"2007797_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/(SICI)1096-9926(199802)57:2<93::AID-TERA8>3.0.CO;2-7","volume":"57","author":"FC Fraser","year":"1998","unstructured":"Fraser FC, Gwyn A. Seasonal variation in birth date of children with cleft lip. Teratology. 1998;57(2):93\u201395.","journal-title":"Teratology"},{"issue":"3","key":"2007797_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ijom.2005.08.007","volume":"35","author":"B Krost","year":"2006","unstructured":"Krost B, Schubert J. Influence of season on prevalence of cleft lip and palate. Int J Oral Maxillofac Surg. 2006;35(3): 215\u2013218.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"2007797_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1597\/02-076","volume":"41","author":"LD Vallino-Napoli","year":"2004","unstructured":"Vallino-Napoli LD, Riley MM, Halliday J. An epidemiologic study of isolated cleft lip, palate, or both in Victoria, Australia from 1983 to 2000. Cleft Palate Craniofac J. 2004;41(2):185\u2013194.","journal-title":"Cleft Palate Craniofac J"},{"key":"2007797_CR12","doi-asserted-by":"crossref","unstructured":"Chung MK, Lao TT, Ting YH, Suen SH, Leung TY, Lau TK. Is there seasonality in the incidence of oral-facial clefts? J Matern Fetal Neonatal Med. 2011;1(14).","DOI":"10.3109\/14767058.2011.629251"},{"issue":"1","key":"2007797_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M","volume":"79","author":"LA Croen","year":"1998","unstructured":"Croen LA, Shaw GM, Wasserman CR, Tolarova MM. Racial and ethnic variations in the prevalence of orofacial clefts in California, 1983\u20131992. Am J Med Genet. 1998;79(1):42\u201347.","journal-title":"Am J Med Genet"},{"issue":"1","key":"2007797_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/00000637-199807000-00002","volume":"41","author":"A Chuangsuwanich","year":"1998","unstructured":"Chuangsuwanich A, Aojanepong C, Muangsombut S, Tongpiew P. Epidemiology of cleft lip and palate in Thailand. Ann Plast Surg. 1998;41(1):7\u201310.","journal-title":"Ann Plast Surg"},{"issue":"1","key":"2007797_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3346\/jkms.2002.17.1.49","volume":"17","author":"S Kim","year":"2002","unstructured":"Kim S, Kim WJ, Oh C, Kim JC. Cleft lip and palate incidence among the live births in the Republic of Korea. J Korean Med Sci. 2002;17(1):49\u201352.","journal-title":"J Korean Med Sci"},{"issue":"6","key":"2007797_CR16","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1054\/bjom.2000.0539","volume":"38","author":"N Natsume","year":"2000","unstructured":"Natsume N, Kawai T, Kohama G, et al. Incidence of cleft lip or palate in 303738 Japanese babies born between 1994 and 1995. Br J Oral Maxillofac Surg. 2000;38(6):605\u2013607.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"1","key":"2007797_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0890-6238(95)02013-6","volume":"10","author":"B Laumon","year":"1996","unstructured":"Laumon B, Martin JL, Collet P, Bertucat I, Verney MP, Robert E. Exposure to organic solvents during pregnancy and oral clefts: a case-control study. Reprod Toxicol. 1996;10(1):15\u201319.","journal-title":"Reprod Toxicol"},{"issue":"1","key":"2007797_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00001648-199501000-00006","volume":"6","author":"T Nurminen","year":"1995","unstructured":"Nurminen T, Rantala K, Kurppa K, Holmberg PC. Agricultural work during pregnancy and selected structural malformations in Finland. Epidemiology. 1995;6(1):23\u201330.","journal-title":"Epidemiology"},{"key":"2007797_CR19","doi-asserted-by":"crossref","unstructured":"Sperber G. Formation of the primary and secondary palate. In: Wyszynski D, ed. Cleft Lip and Palate: From Origin to Treatment. New York, NY: Oxford University Press; 2002:5\u201324.","DOI":"10.1093\/oso\/9780195139068.003.0001"},{"key":"2007797_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1471-0528.2003.00011.x","volume":"110","author":"Judith Lumley","year":"2003","unstructured":"Lumley J. Defining the problem: the epidemiology of preterm birth. BJOG. 2003;110(suppl 20):3\u20137.","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"issue":"7","key":"2007797_CR21","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1289\/ehp.9759","volume":"115","author":"ML Bell","year":"2007","unstructured":"Bell ML, Ebisu K, Belanger K. Ambient air pollution and low birth weight in Connecticut and Massachusetts. Environ Health Perspect. 2007;115(7):1118\u20131124.","journal-title":"Environ Health Perspect"},{"issue":"3","key":"2007797_CR22","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1093\/humrep\/deg102","volume":"18","author":"BE Lee","year":"2003","unstructured":"Lee BE, Ha EH, Park HS, et al. Exposure to air pollution during different gestational phases contributes to risks of low birth weight. Hum Reprod. 2003;18(3):638\u2013643.","journal-title":"Hum Reprod"},{"issue":"5","key":"2007797_CR23","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1289\/ehp.10952","volume":"116","author":"M Brauer","year":"2008","unstructured":"Brauer M, Lencar C, Tamburic L, Koehoorn M, Demers P, Karr C. A cohort study of traffic-related air pollution impacts on birth outcomes. Environ Health Perspect. 2008;116(5):680\u2013686.","journal-title":"Environ Health Perspect"},{"key":"2007797_CR24","doi-asserted-by":"crossref","unstructured":"Maroziene L, Grazuleviciene R. Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study. Environ Health. 2002;1(1):6.","DOI":"10.1186\/1476-069X-1-6"},{"issue":"6","key":"2007797_CR25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1080\/00039896.1995.9935976","volume":"50","author":"X Xu","year":"1995","unstructured":"Xu X, Ding H, Wang X. Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Arch Environ Health. 1995;50(6):407\u2013415.","journal-title":"Arch Environ Health"},{"issue":"6","key":"2007797_CR26","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1365-3016.2006.00759.x","volume":"20","author":"M Huynh","year":"2006","unstructured":"Huynh M, Woodruff TJ, Parker JD, Schoendorf KC. Relationships between air pollution and preterm birth in California. Paediatr Perinat Epidemiol. 2006;20(6):454\u2013461.","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"5","key":"2007797_CR27","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1097\/00001648-200009000-00004","volume":"11","author":"B Ritz","year":"2000","unstructured":"Ritz B, Yu F, Chapa G, Fruin S. Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology. 2000;11(5):502\u2013511.","journal-title":"Epidemiology"},{"issue":"4","key":"2007797_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1136\/oem.2009.045997","volume":"67","author":"H Dolk","year":"2010","unstructured":"Dolk H, Armstrong B, Lachowycz K, et al. Ambient air pollution and risk of congenital anomalies in England, 1991\u20131999. Occup Environ Med. 2010;67(4):223\u2013227.","journal-title":"Occup Environ Med"},{"key":"2007797_CR29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0076-6879(08)36001-7","volume":"436","author":"MN Hughes","year":"2008","unstructured":"Hughes MN. Chemistry of nitric oxide and related species. Methods Enzymol. 2008;436:3\u201319.","journal-title":"Methods Enzymol"},{"issue":"4","key":"2007797_CR30","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1258\/ebm.2009.009285","volume":"235","author":"T Suzuki","year":"2010","unstructured":"Suzuki T, Nagamatsu C, Kushima T, et al. Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation. Exp Biol Med (Maywood). 2010;235(4):455\u2013462.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"2007797_CR31","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44\u201384.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"2007797_CR32","first-page":"8","volume":"61","author":"S Cordier","year":"2004","unstructured":"Cordier S, Chevrier C, Robert-Gnansia E, Lorente C, Brula P, Hours M. Risk of congenital anomalies in the vicinity of municipal solid waste incinerators. Occup Environ Med. 2004;61(1):8\u201315.","journal-title":"Occup Environ Med"},{"issue":"10","key":"2007797_CR33","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1289\/ehp.11311","volume":"116","author":"BF Hwang","year":"2008","unstructured":"Hwang BF, Jaakkola JJ. Ozone and other air pollutants and the risk of oral clefts. Environ Health Perspect. 2008;116(10):1411\u20131415.","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2007797_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/humupd\/4.1.3","volume":"4","author":"M Rosselli","year":"1998","unstructured":"Rosselli M, Keller PJ, Dubey RK. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update. 1998;4(1):3\u201324.","journal-title":"Hum Reprod Update"},{"issue":"18-19","key":"2007797_CR35","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/S0024-3205(99)00439-7","volume":"65","author":"L'. Bergendi","year":"1999","unstructured":"Bergendi L, Benes L, Durackova Z, Ferencik M. Chemistry, physiology and pathology of free radicals. Life Sci. 1999; 65(18\u201319):1865\u20131874.","journal-title":"Life Sciences"},{"key":"2007797_CR36","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1749-6632.1999.tb08007.x","volume":"890","author":"CC Chiueh","year":"1999","unstructured":"Chiueh CC. Neuroprotective properties of nitric oxide. Ann N Y Acad Sci. 1999;890:301\u2013311.","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"2007797_CR37","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/IGC.0b013e3181b7a35e","volume":"20","author":"A Barut","year":"2010","unstructured":"Barut A, Harma M, Arikan I, Harma MI, Barut F. Endothelial nitric oxide synthase expression in gestational trophoblastic diseases. Int J Gynecol Cancer. 2010;20(3):337\u2013340.","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"2007797_CR38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1530\/rep.0.1240049","volume":"124","author":"TG Burnett","year":"2002","unstructured":"Burnett TG, Tash JS, Hunt JS. Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice. Reproduction. 2002;124(1):49\u201357.","journal-title":"Reproduction"},{"issue":"1","key":"2007797_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/BC.2004.001","volume":"385","author":"LA Ridnour","year":"2004","unstructured":"Ridnour LA, Thomas DD, Mancardi D, et al. The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol Chem. 2004;385(1):1\u201310.","journal-title":"Biol Chem"},{"issue":"12","key":"2007797_CR40","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1016\/j.freeradbiomed.2008.03.016","volume":"44","author":"MD Rees","year":"2008","unstructured":"Rees MD, Kennett EC, Whitelock JM, Davies MJ. Oxidative damage to extracellular matrix and its role in human pathologies. Free Radic Biol Med. 2008;44(12):1973\u20132001.","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"2007797_CR41","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/bdra.20386","volume":"79","author":"PG Alexander","year":"2007","unstructured":"Alexander PG, Chau L, Tuan RS. Role of nitric oxide in chick embryonic organogenesis and dysmorphogenesis. Birth Defects Res A Clin Mol Teratol. 2007;79(8):581\u2013594.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"2007797_CR42","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/aje\/kwi189","volume":"162","author":"SM Gilboa","year":"2005","unstructured":"Gilboa SM, Mendola P, Olshan AF, et al. Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997\u20132000. Am J Epidemiol. 2005;162(3): 238\u2013252.","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2007797_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/aje\/155.1.17","volume":"155","author":"B Ritz","year":"2002","unstructured":"Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA. Ambient air pollution and risk of birth defects in Southern California. Am J Epidemiol. 2002;155(1):17\u201325.","journal-title":"Am J Epidemiol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719112466311.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719112466311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719112466311\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719112466311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719112466311.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:49:21Z","timestamp":1714783761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719112466311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["2007797"],"URL":"https:\/\/doi.org\/10.1177\/1933719112466311","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"30 December 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}