{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:38:46Z","timestamp":1768322326922,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1177\/1933719112468952","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T03:22:58Z","timestamp":1356664978000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Silk-Based Injectable Biomaterial as an Alternative to Cervical Cerclage: An In Vitro Study"],"prefix":"10.1007","volume":"20","author":[{"given":"Asha J.","family":"Heard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Socrate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Errol R.","family":"Norwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"House","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"issue":"24","key":"20080929_CR1","first-page":"1","volume":"58","author":"JA Martin","year":"2010","unstructured":"Martin JA, Hamilton BE, Sutton PD, et al. Births: final data for 2007. Natl Vital Stat Rep. 2010;58(24):1\u201385.","journal-title":"Natl Vital Stat Rep"},{"key":"20080929_CR2","volume-title":"Birth: Causes, Consequences, and Prevention","author":"Institute of Medicine","year":"2006","unstructured":"Institute of Medicine. Preterm Birth: Causes, Consequences, and Prevention. Washington DC: National Academies Press; 2006."},{"issue":"17","key":"20080929_CR3","first-page":"1","volume":"58","author":"TJ Mathews","year":"2010","unstructured":"Mathews TJ, MacDorman MF. Infant mortality statistics from the 2006 period linked birth\/infant death data set. Natl Vital Stat Rep. 2010; 58(17):1\u201331.","journal-title":"Natl Vital Stat Rep"},{"issue":"9608","key":"20080929_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0140-6736(08)60136-1","volume":"371","author":"S Saigal","year":"2008","unstructured":"Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 2008; 371(9608):261\u2013269.","journal-title":"Lancet"},{"issue":"9","key":"20080929_CR5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1056\/NEJM199602293340904","volume":"334","author":"JD Iams","year":"1996","unstructured":"Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery. N Engl J Med. 1996; 334(9):567\u2013572.","journal-title":"N Engl J Med"},{"issue":"11","key":"20080929_CR6","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1001\/jama.286.11.1340","volume":"286","author":"J Owen","year":"2001","unstructured":"Owen J, Yost N, Berghella V, et al. Mid-trimester endovaginal sonography in women at high risk for spontaneous preterm birth. JAMA. 2001; 286(11):1340\u20131348.","journal-title":"JAMA"},{"issue":"5","key":"20080929_CR7","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1056\/NEJMoa067815","volume":"357","author":"EB Fonseca","year":"2007","unstructured":"Fonseca EB, Celik E, Parra M, et al. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007; 357(5):462\u2013469.","journal-title":"N Engl J Med"},{"issue":"1","key":"20080929_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/uog.9017","volume":"38","author":"SS Hassan","year":"2011","unstructured":"Hassan SS, Romero R, Vidyadhari D, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2011;38(1):18\u201331.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"20080929_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ajog.2010.02.004","volume":"203","author":"JD Iams","year":"2010","unstructured":"Iams JD, Berghella V. Care for women with prior preterm birth. Am J Obstet Gynecol. 2010;203(2):89\u2013100.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"20080929_CR10","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/uog.3850","volume":"28","author":"M House","year":"2006","unstructured":"House M, Socrate S. The cervix as a biomechanical structure. Ultrasound Obstet Gynecol. 2006;28(6):745\u2013749.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"20080929_CR11","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1053\/j.semperi.2009.06.002","volume":"33","author":"M House","year":"2009","unstructured":"House M, Kaplan DL, Socrate S. Relationships between Mechanical Properties and Extracellular Matrix Constituents of the Cervical Stroma during Pregnancy. Semin Perinatol. 2009; 33(5):300\u2013307.","journal-title":"Semin Perinatol"},{"issue":"4","key":"20080929_CR12","doi-asserted-by":"publisher","first-page":"e371","DOI":"10.1016\/j.ajog.2009.08.015","volume":"201","author":"J Owen","year":"2009","unstructured":"Owen J, Hankins G, Iams JD, et al. Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol. 2009;201(4):e371\u2013378.","journal-title":"Am J Obstet Gynecol"},{"issue":"(9424)","key":"20080929_CR13","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/S0140-6736(04)16351-4","volume":"363","author":"MS To","year":"2004","unstructured":"To MS, Alfirevic Z, Heath VC, et al. Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial. Lancet. 2004;363(9424):1849\u201353.","journal-title":"Lancet"},{"issue":"5991","key":"20080929_CR14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1126\/science.1188936","volume":"329","author":"FG Omenetto","year":"2010","unstructured":"Omenetto FG, Kaplan DL. New opportunities for an ancient material. Science. 2010;329(5991):528\u2013531.","journal-title":"Science"},{"key":"20080929_CR15","doi-asserted-by":"publisher","first-page":"6161","DOI":"10.1021\/ma0610109","volume":"39","author":"X Hu","year":"2006","unstructured":"Hu X, Kaplan D, Cebe P. Determining beta-sheet crystallinity in fibrous proteins by thermal analysis and infrared spectroscopy. Macromolecules. 2006;39:6161\u20136170.","journal-title":"Macromolecules"},{"key":"20080929_CR16","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1021\/ma071551d","volume":"41","author":"X Hu","year":"2008","unstructured":"Hu X, Kaplan D, Cebe P. Dynamic protein-water relationships during beta-sheet formation. Macromolecules. 2008;41: 3939\u20133948.","journal-title":"Macromolecules"},{"issue":"8","key":"20080929_CR17","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.biomaterials.2007.11.003","volume":"29","author":"X Wang","year":"2008","unstructured":"Wang X, Kluge JA, Leisk GG, Kaplan DL. Sonication-induced gelation of silk fibroin for cell encapsulation. Biomaterials. 2008;29(8):1054\u20131064.","journal-title":"Biomaterials"},{"issue":"7","key":"20080929_CR18","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.bpj.2009.07.028","volume":"97","author":"T Yucel","year":"2009","unstructured":"Yucel T, Cebe P, Kaplan DL. Vortex-induced injectable silk fibroin hydrogels. Biophys J. 2009;97(7):2044\u20132050.","journal-title":"Biophys J"},{"issue":"2","key":"20080929_CR19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jsb.2009.12.012","volume":"170","author":"T Yucel","year":"2010","unstructured":"Yucel T, Kojic N, Leisk GG, Lo TJ, Kaplan DL. Non-equilibrium silk fibroin adhesives. J Struct Biol. 2010;170(2):406\u2013412.","journal-title":"J Struct Biol"},{"issue":"32","key":"20080929_CR20","doi-asserted-by":"publisher","first-page":"8121","DOI":"10.1016\/j.biomaterials.2010.07.044","volume":"31","author":"X Hu","year":"2011","unstructured":"Hu X, Wang X, Rnjak J, Weiss AS, Kaplan DL. Biomaterials derived from silk-tropoelastin protein systems. Biomaterials. 2011; 31(32):8121\u20138131.","journal-title":"Biomaterials"},{"key":"20080929_CR21","doi-asserted-by":"crossref","unstructured":"Hu X, Lu Q, Sun L, et al. Biomaterials from ultrasonication-induced silk fibroin-hyaluronic acid hydrogels [published online October 13, 2010]. Biomacromolecules. 2010.","DOI":"10.1021\/bm1010504"},{"issue":"4","key":"20080929_CR22","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/jbm.a.33149","volume":"98","author":"MA Serban","year":"2011","unstructured":"Serban MA, Panilaitis B, Kaplan DL. Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives. J Biomed Mater Res A. 2011;98(4):567\u2013575.","journal-title":"J Biomed Mater Res A"},{"issue":"15","key":"20080929_CR23","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1016\/j.biomaterials.2004.07.044","volume":"26","author":"UJ Kim","year":"2005","unstructured":"Kim UJ, Park J, Kim HJ, Wada M, Kaplan DL. Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin. Biomaterials. 2005;26(15):2775\u20132785.","journal-title":"Biomaterials"},{"issue":"35","key":"20080929_CR24","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.1016\/j.biomaterials.2007.08.008","volume":"28","author":"M Lovett","year":"2007","unstructured":"Lovett M, Cannizzaro C, Daheron L, Messmer B, Vunjak-Novakovic G, Kaplan DL. Silk fibroin microtubes for blood vessel engineering. Biomaterials. 2007;28(35):5271\u20135279.","journal-title":"Biomaterials"},{"issue":"1","key":"20080929_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0301-4622(00)00213-1","volume":"89","author":"X Chen","year":"2001","unstructured":"Chen X, Shao Z, Marinkovic NS, Miller LM, Zhou P, Chance MR. Conformation transition kinetics of regenerated Bombyx mori silk fibroin membrane monitored by time-resolved FTIR spectroscopy. Biophys Chem. 2001;89(1):25\u201334.","journal-title":"Biophys Chem"},{"issue":"7","key":"20080929_CR26","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1111\/j.1537-2995.2008.01703.x","volume":"48","author":"WD Spotnitz","year":"2008","unstructured":"Spotnitz WD, Burks S. Hemostats, sealants, and adhesives: components of the surgical toolbox. Transfusion. 2008;48(7):1502\u20131516.","journal-title":"Transfusion"},{"issue":"6","key":"20080929_CR27","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1089\/ten.tea.2009.0457","volume":"16","author":"M House","year":"2010","unstructured":"House M, Sanchez CC, Rice WL, Socrate S, Kaplan DL. Cervical tissue engineering using silk scaffolds and human cervical cells. Tissue Eng Part A. 2010;16(6):2101\u20132112.","journal-title":"Tissue Eng Part A"},{"issue":"5","key":"20080929_CR28","doi-asserted-by":"publisher","first-page":"e481","DOI":"10.1016\/j.ajog.2007.05.041","volume":"197","author":"L Pereira","year":"2007","unstructured":"Pereira L, Cotter A, Gomez R, et al.. Expectant management compared with physical examination-indicated cerclage (EM-PEC) in selected women with a dilated cervix at 14(0\/7)-25(6\/7) weeks: results from the EM-PEC international cohort study. Am J Obstet Gynecol. 2007;197(5):483 e481-e488.","journal-title":"Am J Obstet Gynecol"},{"issue":"2 Pt 1","key":"20080929_CR29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/01.AOG.0000187896.04535.e6","volume":"107","author":"G Daskalakis","year":"2006","unstructured":"Daskalakis G, Papantoniou N, Mesogitis S, Antsaklis A. Management of cervical insufficiency and bulging fetal membranes. Obstet Gynecol. 2006;107(2 Pt 1):221\u2013226.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"20080929_CR30","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/AOG.0b013e31820afaf2","volume":"117","author":"HJ Landy","year":"2011","unstructured":"Landy HJ, Laughon SK, Bailit JL, et al. Characteristics associated with severe perineal and cervical lacerations during vaginal delivery. Obstet Gynecol. 2011;117(3):627\u2013635.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"20080929_CR31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/01.AOG.0000168435.17200.53","volume":"106","author":"V Berghella","year":"2005","unstructured":"Berghella V, Odibo AO, To MS, Rust OA, Althuisius SM. Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol. 2005; 106(1):181\u2013189.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"20080929_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/glycob\/cwh137","volume":"15","author":"KJ Straach","year":"2005","unstructured":"Straach KJ, Shelton JM, Richardson JA, Hascall VC, Mahendroo MS. Regulation of hyaluronan expression during cervical ripening. Glycobiology. 2005;15(1):55\u201365.","journal-title":"Glycobiology"},{"issue":"1","key":"20080929_CR33","first-page":"88","volume":"81","author":"R Osmers","year":"1993","unstructured":"Osmers R, Rath W, Pflanz MA, Kuhn W, Stuhlsatz HW, Szeverenyi M. Glycosaminoglycans in cervical connective tissue during pregnancy and parturition. Obstet Gynecol. 1993;81(1):88\u201392.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"20080929_CR34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.actbio.2007.04.009","volume":"4","author":"KM Myers","year":"2008","unstructured":"Myers KM, Paskaleva AP, House M, Socrate S. Mechanical and biochemical properties of human cervical tissue. Acta Biomater. 2008;4(1):104\u2013116.","journal-title":"Acta Biomater"},{"issue":"2","key":"20080929_CR35","doi-asserted-by":"publisher","first-page":"021003","DOI":"10.1115\/1.3197847","volume":"132","author":"KM Myers","year":"2010","unstructured":"Myers KM, Socrate S, Paskaleva AP, House M. A Study of the Anisotropy and Tension\/Compression Behavior of Human Cervical Tissue. J Biomech Eng. 2010;132(2):021003-021015.","journal-title":"J Biomech Eng"},{"issue":"3","key":"20080929_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0142-9612(02)00353-8","volume":"24","author":"GH Altman","year":"2003","unstructured":"Altman GH, Diaz F, Jakuba C, et al. Silk-based biomaterials. Biomaterials. 2003;24(3):401\u2013416.","journal-title":"Biomaterials"},{"issue":"24-25","key":"20080929_CR37","doi-asserted-by":"publisher","first-page":"3415","DOI":"10.1016\/j.biomaterials.2008.05.002","volume":"29","author":"Y Wang","year":"2008","unstructured":"Wang Y, Rudym DD, Walsh A, et al.. In vivo degradation of three-dimensional silk fibroin scaffolds. Biomaterials. 2008; 29(24\u201325):3415\u20133428.","journal-title":"Biomaterials"},{"issue":"2","key":"20080929_CR38","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.biomaterials.2004.02.047","volume":"26","author":"L Meinel","year":"2005","unstructured":"Meinel L, Hofmann S, Karageorgiou V, et al.. The inflammatory responses to silk films in vitro and in vivo. Biomaterials. 2005; 26(2):147\u2013155.","journal-title":"Biomaterials"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719112468952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719112468952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719112468952\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719112468952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719112468952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:26:15Z","timestamp":1656811575000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719112468952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["20080929"],"URL":"https:\/\/doi.org\/10.1177\/1933719112468952","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"30 December 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}