{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:16:16Z","timestamp":1789078576774,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1177\/1933719115580995","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:51:28Z","timestamp":1429145488000},"page":"1421-1428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women"],"prefix":"10.1007","volume":"22","author":[{"given":"Shunyao","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuande","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjue","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"issue":"11","key":"22111421_CR1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/j.1471-0528.1978.tb15835.x","volume":"5","author":"FA Van Assche","year":"1978","unstructured":"Van Assche FA, Aerts L, De Prins F. A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol. 1978;5(11):818\u2013820.","journal-title":"Br J Obstet Gynaecol"},{"issue":"3","key":"22111421_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tem.2009.11.001","volume":"1","author":"S Rieck","year":"2010","unstructured":"Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab. 2010;1(3):151\u2013158.","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"22111421_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/gm232","volume":"3","author":"RM Watanabe","year":"2011","unstructured":"Watanabe RM. Inherited destiny? Genetics and gestational diabetes mellitus. Genome Med. 2011;3(3):18.","journal-title":"Genome Med."},{"issue":"4","key":"22111421_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/humupd\/dmt013","volume":"19","author":"C Zhang","year":"2013","unstructured":"Zhang C, Bao W, Rong Y, et al. Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum Reprod Update. 2013;19(4):376\u2013390.","journal-title":"Hum Reprod Update"},{"issue":"2","key":"22111421_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2337\/db11-1034","volume":"61","author":"SH Kwak","year":"2012","unstructured":"Kwak SH, Kim SH, Cho YM, et al. A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes. 2012;61(2):531\u2013541.","journal-title":"Diabetes"},{"issue":"9","key":"22111421_CR6","doi-asserted-by":"publisher","first-page":"e45882","DOI":"10.1371\/journal.pone.0045882","volume":"7","author":"H Mao","year":"2012","unstructured":"Mao H, Li Q, Gao S. Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus. PLoS One. 2012;7(9):e45882.","journal-title":"PLoS One"},{"issue":"11","key":"22111421_CR7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s11892-014-0551-8","volume":"14","author":"L Marullo","year":"2014","unstructured":"Marullo L, El-Sayed Moustafa JS, Prokopenko I. Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits. Curr Diab Rep. 2014;14(11):551.","journal-title":"Curr Diab Rep."},{"issue":"6","key":"22111421_CR8","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.2337\/db13-0949","volume":"63","author":"AS Dimas","year":"2014","unstructured":"Dimas AS, Lagou V, Barker A, et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 2014;63(6):2158\u20132171.","journal-title":"Diabetes"},{"issue":"11","key":"22111421_CR9","doi-asserted-by":"publisher","first-page":"e26953","DOI":"10.1371\/journal.pone.0026953","volume":"6","author":"Y Wang","year":"2011","unstructured":"Wang Y, Nie M, Li W, et al. Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population. PLoS One. 2011;6(11):e26953.","journal-title":"PLoS One"},{"issue":"7","key":"22111421_CR10","doi-asserted-by":"publisher","first-page":"e40113","DOI":"10.1371\/journal.pone.0040113","volume":"7","author":"S Liao","year":"2012","unstructured":"Liao S, Liu Y, Tan Y, et al. Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women. PLoS One. 2012;7(7):e40113.","journal-title":"PLoS One"},{"issue":"3","key":"22111421_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11154-010-9144-2","volume":"11","author":"K Bennet","year":"2010","unstructured":"Bennet K, James C, Hussain K. Pancreatic beta-cell K (ATP) channels: hypoglycaemia and hyperglycaemia. Rev Endocr Metab Disord. 2010;11(3):157\u2013163.","journal-title":"Rev Endocr Metab Disord."},{"issue":"50","key":"22111421_CR12","doi-asserted-by":"publisher","first-page":"41808","DOI":"10.1074\/jbc.M112.376558","volume":"287","author":"S Brambillasca","year":"2012","unstructured":"Brambillasca S, Altkrueger A, Colombo SF, et al. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. J Biol Chem. 2012;287(50):41808\u20134119.","journal-title":"J Biol Chem."},{"issue":"3","key":"22111421_CR13","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1172\/JCI64095","volume":"123","author":"JA Kushner","year":"2013","unstructured":"Kushner JA. The role of aging upon \u03b2 cell turnover. J Clin Invest. 2013;123(3):990\u2013995.","journal-title":"J Clin Invest"},{"issue":"1","key":"22111421_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/8751","volume":"22","author":"SG Rane","year":"1999","unstructured":"Rane SG, Dubus P, Mettus RV, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999;22(1):44\u201352.","journal-title":"Nat Genet."},{"issue":"8","key":"22111421_CR15","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1210\/en.2004-0281","volume":"145","author":"L Wang","year":"2004","unstructured":"Wang L, Coffinier C, Thomas MK, et al. Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology. 2004; 145(8):3941\u20133949.","journal-title":"Endocrinology"},{"issue":"7435","key":"22111421_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature11793","volume":"494","author":"JW Kornfeld","year":"2013","unstructured":"Kornfeld JW, Baitzel C, Ko\u00a8nner AC, et al. Obesity-induced over-expression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature. 2013;494(7435):111\u2013115.","journal-title":"Nature"},{"issue":"3","key":"22111421_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ng.1053","volume":"44","author":"A Bonnefond","year":"2012","unstructured":"Bonnefond A, Cl\u00e9ment N, Fawcett K, et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet. 2012;44(3):297\u2013301.","journal-title":"Nat Genet."},{"issue":"8 Suppl 1","key":"22111421_CR18","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1186\/1471-2350-8-S1-S16","volume":"19","author":"JB Meigs","year":"2007","unstructured":"Meigs JB, Manning AK, Fox CS, et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet. 2007;19(8 Suppl 1):S16.","journal-title":"BMC Med Genet."},{"issue":"8","key":"22111421_CR19","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.2337\/db09-1386","volume":"59","author":"G Chauhan","year":"2010","unstructured":"Chauhan G, Spurgeon CJ, Tabassum R, et al. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes. 2010;59(8):2068\u20132074.","journal-title":"Diabetes"},{"issue":"9","key":"22111421_CR20","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s00125-008-1083-z","volume":"51","author":"MJ Groenewoud","year":"2008","unstructured":"Groenewoud MJ, Dekker JM, Fritsche A, et al. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia. 2008;51(9):1659\u20131663.","journal-title":"Diabetologia"},{"issue":"4","key":"22111421_CR21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00125-008-0926-y","volume":"51","author":"K Kirchhoff","year":"2008","unstructured":"Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008;51(4): 597\u2013601.","journal-title":"Diabetologia"},{"issue":"9","key":"22111421_CR22","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.2337\/db09-0117","volume":"58","author":"A Stanc\u00e1kov\u00e1","year":"2009","unstructured":"Stanc\u00e1kov\u00e1 A, Kuulasmaa T, Paananen J, et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes. 2009;58(9): 2129\u20132136.","journal-title":"Diabetes"},{"issue":"12","key":"22111421_CR23","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.2337\/db07-0856","volume":"56","author":"N Grarup","year":"2007","unstructured":"Grarup N, Rose CS, Andersson EA, et al. Studies of association of variants near the HHEX, CDKN2A\/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes. 2007;56(12):3105\u20133111.","journal-title":"Diabetes"},{"issue":"1","key":"22111421_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/ng.288","volume":"41","author":"V Lyssenko","year":"2009","unstructured":"Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41(1):82\u201388.","journal-title":"Nat Genet."},{"issue":"8","key":"22111421_CR25","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s00125-009-1392-x","volume":"52","author":"C Langenberg","year":"2009","unstructured":"Langenberg C, Pascoe L, Mari A, et al. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia. 2009; 52(8):1537\u20131542.","journal-title":"Diabetologia"},{"issue":"6","key":"22111421_CR26","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.2337\/db08-1660","volume":"58","author":"T Spars\u00f8","year":"2009","unstructured":"Spars\u00f8 T, Bonnefond A, Andersson E, et al. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucosestimulated insulin release: studies involving 19,605 Europeans. Diabetes. 2009;58(6):1450\u20131456.","journal-title":"Diabetes"},{"issue":"suppl 1","key":"22111421_CR27","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.2337\/diacare.26.2007.S103","volume":"26","author":"American Diabetes Association","year":"2003","unstructured":"American Diabetes Association. Gestational diabetes mellitus. Diabetes Care. 2003;26(suppl 1):S103\u2013S105.","journal-title":"Diabetes Care"},{"issue":"20","key":"22111421_CR28","first-page":"2477","volume":"122","author":"F Wang","year":"2009","unstructured":"Wang F, Han XY, Ren Q, et al. Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population. Chin Med J (Engl). 2009;122(20):2477\u20132482.","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"22111421_CR29","doi-asserted-by":"publisher","first-page":"e93961","DOI":"10.1371\/journal.pone.0093961","volume":"9","author":"L Qiu","year":"2014","unstructured":"Qiu L, Na R, Xu R, et al. Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes. PLoS One. 2014;9(4):e93961.","journal-title":"PLoS One"},{"issue":"5","key":"22111421_CR30","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/jhg.2012.25","volume":"57","author":"F Lu","year":"2012","unstructured":"Lu F, Qian Y, Li H, et al. Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese. J Hum Genet. 2012;57(5):320\u2013325.","journal-title":"J Hum Genet."},{"issue":"10","key":"22111421_CR31","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.2337\/db08-0047","volume":"57","author":"Y Wu","year":"2008","unstructured":"Wu Y, Li H, Loos RJ, et al. Common variants in CDKAL1, CDKN2A\/B, IGF2BP2, SLC30A8, and HHEX\/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008;57(10):2834\u20132842.","journal-title":"Diabetes"},{"issue":"2","key":"22111421_CR32","doi-asserted-by":"publisher","first-page":"e9153","DOI":"10.1371\/journal.pone.0009153","volume":"5","author":"J Wen","year":"2010","unstructured":"Wen J, Ro\u00a8nn T, Olsson A, et al. Investigation of type 2 diabetes risk alleles support CDKN2A\/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One. 2010;5(2):e9153.","journal-title":"PLoS One"},{"issue":"12","key":"22111421_CR33","doi-asserted-by":"publisher","first-page":"e52938","DOI":"10.1371\/journal.pone.0052938","volume":"7","author":"X Zhang","year":"2012","unstructured":"Zhang X, Qiao H, Zhao Y, et al. Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population. PLoS One. 2012;7(12):e52938.","journal-title":"PLoS One"},{"issue":"4","key":"22111421_CR34","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2337\/db08-1064","volume":"58","author":"C Wang","year":"2009","unstructured":"Wang C, Hu C, Zhang R, et al. Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population. Diabetes. 2009;58(4):1023\u20131027.","journal-title":"Diabetes"},{"issue":"5","key":"22111421_CR35","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1007\/s00125-009-1297-8","volume":"52","author":"T Ro\u00a8nn","year":"2009","unstructured":"Ro\u00a8nn T, Wen J, Yang Z, et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009;52(5):830\u2013833.","journal-title":"Diabetologia"},{"issue":"7","key":"22111421_CR36","doi-asserted-by":"publisher","first-page":"e11428","DOI":"10.1371\/journal.pone.0011428","volume":"5","author":"CH Tam","year":"2010","unstructured":"Tam CH, Ho JS, Wang Y, et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One. 2010;5(7):e11428.","journal-title":"PLoS One"},{"issue":"2","key":"22111421_CR37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00125-008-1196-4","volume":"52","author":"YM Cho","year":"2009","unstructured":"Cho YM, Kim TH, Lim S, et al. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Diabetologia. 2009;52(2):253\u2013261.","journal-title":"Diabetologia"},{"issue":"7","key":"22111421_CR38","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.2337\/dc10-0646","volume":"33","author":"RA DeFronzo","year":"2010","unstructured":"DeFronzo RA, Matsuda M. Reduced time points to calculate the composite index (letter). Diabetes Care. 2010;33(7):e93.","journal-title":"Diabetes Care"},{"issue":"7","key":"22111421_CR39","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412\u2013419.","journal-title":"Diabetologia"},{"issue":"10","key":"22111421_CR40","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.2337\/db13-1154","volume":"62","author":"D Meyre","year":"2013","unstructured":"Meyre D, Pare G. Genetic dissection of diabetes: facing the giant. Diabetes. 2013;62(10):3338\u20133340.","journal-title":"Diabetes"},{"issue":"8","key":"22111421_CR41","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.2337\/db12-1627","volume":"2","author":"A Jonsson","year":"2013","unstructured":"Jonsson A, Ladenvall C, Ahluwalia TS, et al. Effects of common genetic variants associated with type 2 diabetes and glycemic traits on \u03b1- and \u03b2-cell function and insulin action in humans. Diabetes. 2013;2(8):2978\u2013283.","journal-title":"Diabetes"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115580995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719115580995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719115580995\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719115580995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115580995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:39:22Z","timestamp":1656812362000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719115580995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["22111421"],"URL":"https:\/\/doi.org\/10.1177\/1933719115580995","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"30 December 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}