{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:58:54Z","timestamp":1771567134775,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1177\/1933719115589409","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T01:05:24Z","timestamp":1433466324000},"page":"1516-1523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ulipristal Acetate Antagonizes the Inhibitory Effect of Progesterone on Ciliary Beat Frequency and Upregulates Steroid Receptor Expression Levels in Human Fallopian Tubes"],"prefix":"10.1007","volume":"22","author":[{"given":"Jiangjing","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"issue":"11","key":"22121516_CR1","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1093\/humrep\/13.11.2991","volume":"13","author":"T Mahmood","year":"1998","unstructured":"Mahmood T, Saridogan E, Smutna S, Habib AM, Djahanbakhch O. The effect of ovarian steroids on epithelial ciliary beat frequency in the human fallopian tube. Hum Reprod 1998; 13(11):2991\u20132994.","journal-title":"Hum Reprod"},{"issue":"1","key":"22121516_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0015-0282(98)00416-6","volume":"71","author":"RC Chian","year":"1999","unstructured":"Chian RC, Ao A, Clarke HJ, Tulandi T, Tan SL. Production of steroids from human cumulus cells treated with different concentrations of gonadotropins during culture in vitro. Fertil Steril. 1999;71(1):61\u201366.","journal-title":"Fertil Steril"},{"issue":"3","key":"22121516_CR3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1055\/s-2004-814336","volume":"36","author":"T Wessel","year":"2004","unstructured":"Wessel T, Schuchter U, Walt H. Ciliary motility in bovine oviducts for sensing rapid non-genomic reactions upon exposure to progesterone. Horm Metab Res. 2004;36(3):136\u2013141.","journal-title":"Horm Metab Res"},{"issue":"10","key":"22121516_CR4","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1093\/humrep\/den260","volume":"23","author":"K Wanggren","year":"2008","unstructured":"Wanggren K, Stavreus-Evers A, Olsson C, Andersson E, Gemzell-Danielsson K. Regulation of muscular contractions in the human fallopian tube through prostaglandins and progestagens. Hum Reprod. 2008;23(10):2359\u20132368.","journal-title":"Hum Reprod"},{"issue":"2","key":"22121516_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1530\/jrf.0.0800487","volume":"80","author":"A Psychoyos","year":"1987","unstructured":"Psychoyos A, Prapas I. Inhibition of egg development and implantation in rats after post-coital administration of the progesterone antagonist RU 486. J Reprod Fertil. 1987;80(2):487\u2013491.","journal-title":"J Reprod Fertil"},{"key":"22121516_CR6","first-page":"D1324","volume":"8","author":"L Cheng","year":"2012","unstructured":"Cheng L, Che Y, Gulmezoglu AM. Interventions for emergency contraception. Cochrane Database Syst Rev. 2012;8:D1324.","journal-title":"Cochrane Database Syst Rev"},{"issue":"9714","key":"22121516_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0140-6736(10)60101-8","volume":"375","author":"AF Glasier","year":"2010","unstructured":"Glasier AF, Cameron ST, Fine PM, et al. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. Lancet 2010;375(9714):555\u2013562.","journal-title":"Lancet"},{"issue":"9","key":"22121516_CR8","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1093\/humrep\/deq157","volume":"25","author":"V Brache","year":"2010","unstructured":"Brache V, Cochon L, Jesam C, et al. Immediate pre-ovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. Hum Reprod. 2010;25(9):2256\u20132263.","journal-title":"Hum Reprod"},{"issue":"5","key":"22121516_CR9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1093\/humrep\/15.5.1092","volume":"15","author":"P Stratton","year":"2000","unstructured":"Stratton P, Hartog B, Hajizadeh N, et al. A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Hum Reprod. 2000;15(5):1092\u20131099.","journal-title":"Hum Reprod"},{"issue":"6","key":"22121516_CR10","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/j.2047-2927.2014.00261.x","volume":"2","author":"JK Ko","year":"2014","unstructured":"Ko JK, Huang VW, Li RH, Yeung WS, Ho PC, Chiu PC. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions. Andrology. 2014;2(6):868\u2013874.","journal-title":"Andrology"},{"issue":"10","key":"22121516_CR11","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1093\/humrep\/deu210","volume":"29","author":"HW Li","year":"2014","unstructured":"Li HW, Liao SB, Yeung WS, Ng EH, O WS, Ho PC. Ulipristal acetate resembles mifepristone in modulating human fallopian tube function. Hum Reprod. 2014;29(10):2156\u20132162.","journal-title":"Hum Reprod"},{"issue":"2","key":"22121516_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1023\/A:1009465900824","volume":"17","author":"Y Paltieli","year":"2000","unstructured":"Paltieli Y, Eibschitz I, Ziskind G, Ohel G, Silbermann M, Weichselbaum A. High progesterone levels and ciliary dysfunction\u2013a possible cause of ectopic pregnancy. J Assist Reprod Genet. 2000;17(2):103\u2013106.","journal-title":"J Assist Reprod Genet"},{"issue":"7","key":"22121516_CR13","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1113\/expphysiol.2010.052555","volume":"95","author":"A Nishimura","year":"2010","unstructured":"Nishimura A, Sakuma K, Shimamoto C, et al. Ciliary beat frequency controlled by oestradiol and progesterone during ovarian cycle in guinea-pig Fallopian tube. Exp Physiol. 2010;95(7): 819\u2013828.","journal-title":"Exp Physiol"},{"issue":"3","key":"22121516_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/humupd\/dmi002","volume":"11","author":"N Chabbert-Buffet","year":"2005","unstructured":"Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM. Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Hum Reprod Update. 2005;11(3):293\u2013307.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"22121516_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0303-7207(01)00743-2","volume":"188","author":"BJ Attardi","year":"2002","unstructured":"Attardi BJ, Burgenson J, Hild SA, et al. CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent anti-progestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914. Mol Cell Endocrinol. 2002;188(1):111\u2013123.","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"22121516_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/molehr\/gan004","volume":"14","author":"Q Xu","year":"2008","unstructured":"Xu Q, Ohara N, Liu J, et al. Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells. Mol Hum Reprod. 2008;14(3):181\u2013191.","journal-title":"Mol Hum Reprod"},{"issue":"6","key":"22121516_CR17","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/j.2047-2927.2014.00261.x","volume":"2","author":"J KY Ko","year":"2014","unstructured":"Ko J KY, Huang VW, Li R HW, Yeung WS, Ho PC, Chiu PC. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions. Andrology. 2014;2(6):868\u2013874.","journal-title":"Andrology"},{"issue":"9","key":"22121516_CR18","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1093\/humrep\/des221","volume":"27","author":"L Communal","year":"2012","unstructured":"Communal L, Vilasco M, Hugon-Rodin J, et al. Ulipristal acetate does not impact human normal breast tissue. Hum Reprod. 2012; 27(9):2785\u20132798.","journal-title":"Hum Reprod"},{"issue":"5","key":"22121516_CR19","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.fertnstert.2011.08.021","volume":"96","author":"P Bouchard","year":"2011","unstructured":"Bouchard P, Chabbert-Buffet N, Fauser BC. Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety. Fertil Steril. 2011;96(5): 1175\u20131189.","journal-title":"Fertil Steril"},{"issue":"12","key":"22121516_CR20","doi-asserted-by":"publisher","first-page":"7940","DOI":"10.1073\/pnas.122225699","volume":"99","author":"Z Liu","year":"2002","unstructured":"Liu Z, Auboeuf D, Wong J, et al. Coactivator\/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proc Natl Acad Sci U S A. 2002;99(12): 7940\u20137944.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"22121516_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1043-2760(01)00527-6","volume":"13","author":"O Hermanson","year":"2002","unstructured":"Hermanson O, Glass CK, Rosenfeld MG. Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol Metab. 2002;13(2):55\u201360.","journal-title":"Trends Endocrinol Metab"},{"issue":"14","key":"22121516_CR22","doi-asserted-by":"publisher","first-page":"12335","DOI":"10.1074\/jbc.M207148200","volume":"278","author":"A Chauchereau","year":"2003","unstructured":"Chauchereau A, Amazit L, Quesne M, Guiochon-Mantel A, Milgrom E. Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1. J Biol Chem. 2003;278(14): 12335\u201312343.","journal-title":"J Biol Chem"},{"issue":"1","key":"22121516_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1210\/er.2003-0023","volume":"25","author":"C Smith","year":"2004","unstructured":"Smith C, O\u2019Malley BW. Coregulator functions: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev. 2004;25(1):45\u201371.","journal-title":"Endocr Rev"},{"issue":"4","key":"22121516_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/molehr\/8.4.333","volume":"8","author":"A Christow","year":"2002","unstructured":"Christow A, Sun X, Gemzell-Danielsson K. Effect of mifepristone and levonorgestrel on expression of steroid receptors in the human Fallopian tube. Mol Hum Reprod. 2002;8(4):333\u2013340.","journal-title":"Mol Hum Reprod"},{"key":"22121516_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1477-7827-11-33","volume":"11","author":"A Bylander","year":"2013","unstructured":"Bylander A, Lind K, Goksor M, Billig H, Larsson DG. The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone. Reprod Biol Endocrinol. 2013;11:33.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"22121516_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.clinthera.2011.11.012","volume":"34","author":"AR Richardson","year":"2012","unstructured":"Richardson AR, Maltz FN. Ulipristal acetate: review of the efficacy and safety of a newly approved agent for emergency contraception. Clin Ther. 2012;34(1):24\u201336.","journal-title":"Clin Ther"},{"issue":"2","key":"22121516_CR27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/1440-1681.12337","volume":"42","author":"W Zhao","year":"2015","unstructured":"Zhao W, Zhu Q, Yan M, et al. Levonorgestrel decreased cilia beat frequency of human fallopian tubes and rat oviducts without changing the morphological structure. Clin Exp Pharmacol Physiol. 2015;42(2):171\u2013178.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"5","key":"22121516_CR28","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.contraception.2014.01.003","volume":"89","author":"DP Levy","year":"2014","unstructured":"Levy DP, Jager M, Kapp N, Abitbol JL. Ulipristal acetate for emergency contraception: postmarketing experience after use by more than 1 million women. Contraception. 2014;89(5):431\u2013433.","journal-title":"Contraception"},{"issue":"3","key":"22121516_CR29","first-page":"287","volume":"54","author":"BA Afzelius","year":"2000","unstructured":"Afzelius BA. Ciliary structure in health and disease. Acta Otorhinolaryngol Belg. 2000;54(3):287\u2013291.","journal-title":"Acta Otorhinolaryngol Belg"},{"issue":"5","key":"22121516_CR30","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0010-7824(98)00034-1","volume":"57","author":"SR Anzaldua","year":"1998","unstructured":"Anzaldua SR, Camacho-Arroyo I, Garcia GA, Cerbon MA. Differential effects of 5 alpha-norethisterone on the histomorphology of the oviduct and uterus of the pregnant rabbit. Contraception. 1998;57(5):349\u2013355.","journal-title":"Contraception"},{"issue":"4","key":"22121516_CR31","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/molehr\/8.4.333","volume":"8","author":"A Christow","year":"2002","unstructured":"Christow A, Sun X, Gemzell-Danielsson K. Effect of mifepristone and levonorgestrel on expression of steroid receptors in the human Fallopian tube. Mol Hum Reprod. 2002;8(4): 333\u2013340.","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"22121516_CR32","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S1472-6483(10)61935-9","volume":"4","author":"HB Croxatto","year":"2002","unstructured":"Croxatto HB. Physiology of gamete and embryo transport through the fallopian tube. Reprod Biomed Online. 2002;4(2):160\u2013169.","journal-title":"Reprod Biomed Online"},{"issue":"8","key":"22121516_CR33","first-page":"2963","volume":"84","author":"PA Mote","year":"1999","unstructured":"Mote PA, Balleine RL, McGowan EM, Clarke CL. Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 1999;84(8):2963\u20132971.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"22121516_CR34","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1677\/joe.0.1670363","volume":"167","author":"CN Mowa","year":"2000","unstructured":"Mowa CN, Iwanaga T. Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat\u2013an analysis by in situ hybridization. J Endocrinol. 2000; 167(3):363\u2013369.","journal-title":"J Endocrinol"},{"issue":"5","key":"22121516_CR35","doi-asserted-by":"publisher","first-page":"E1430","DOI":"10.1152\/ajpendo.00384.2007","volume":"293","author":"R Shao","year":"2007","unstructured":"Shao R, Egecioglu E, Weijdegard B, et al. Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors. Am J Physiol Endocrinol Metab. 2007;293(5):E1430\u2013E1442.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"22121516_CR36","doi-asserted-by":"publisher","first-page":"5146","DOI":"10.1210\/jc.2009-1476","volume":"94","author":"AW Horne","year":"2009","unstructured":"Horne AW, King AE, Shaw E, et al. Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy. J Clin Endocrinol Metab. 2009;94(12): 5146\u20135154.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"22121516_CR37","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0015-0282(16)55208-X","volume":"58","author":"JA Land","year":"1992","unstructured":"Land JA, Arends JW. Immunohistochemical analysis of estrogen and progesterone receptors in fallopian tubes during ectopic pregnancy. Fertil Steril. 1992;58(2):335\u2013337.","journal-title":"Fertil Steril"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115589409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719115589409","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719115589409\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719115589409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115589409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:40:02Z","timestamp":1656812402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719115589409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["22121516"],"URL":"https:\/\/doi.org\/10.1177\/1933719115589409","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"30 December 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}