{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:15:23Z","timestamp":1788894923114,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1177\/1933719115620497","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T01:18:15Z","timestamp":1450747095000},"page":"838-846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enhanced Expression of Contractile-Associated Proteins and Ion Channels in Preterm Delivery Model Mice With Chronic Odontogenic Porphyromonas Gingivalis Infection"],"prefix":"10.1007","volume":"23","author":[{"given":"Hiroshi","family":"Miyoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Teraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Furusho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"issue":"9832","key":"23070838_CR1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","volume":"379","author":"L Liu","year":"2012","unstructured":"Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151\u20132161.","journal-title":"Lancet"},{"issue":"suppl 3","key":"23070838_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","volume":"113","author":"R Romero","year":"2006","unstructured":"Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. Br J Obst Gynecol. 2006;113(suppl 3):17\u201342.","journal-title":"Br J Obst Gynecol"},{"issue":"10","key":"23070838_CR3","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.tem.2004.10.009","volume":"15","author":"MA Elovitz","year":"2004","unstructured":"Elovitz MA, Mrinalini C. Animal models of preterm birth. Trends Endocrinol Metab. 2004;15(10):479\u2013487.","journal-title":"Trends Endocrinol Metab"},{"issue":"5 pt 1","key":"23070838_CR4","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/S0002-9378(94)70180-6","volume":"170","author":"PL Fidel Jr.","year":"1994","unstructured":"Fidel PL Jr., Romero R, Wolf N, et al. Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obst Gynecol. 1994;170(5 pt 1):1467\u20131475.","journal-title":"Am J Obst Gynecol"},{"issue":"5 pt 1","key":"23070838_CR5","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/0002-9378(89)90172-5","volume":"160","author":"R Romero","year":"1989","unstructured":"Romero R, Brody DT, Oyarzun E, et al. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obst Gynecol. 1989;160(5 pt 1):1117\u20131123.","journal-title":"Am J Obst Gynecol"},{"issue":"6198","key":"23070838_CR6","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","volume":"345","author":"R Romero","year":"2014","unstructured":"Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760\u2013765.","journal-title":"Science"},{"issue":"5","key":"23070838_CR7","first-page":"514","volume":"21","author":"JRGMS Challis","year":"2000","unstructured":"Challis JRG MS, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000;21(5):514\u2013550.","journal-title":"Endocr Rev"},{"issue":"4320","key":"23070838_CR8","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1126\/science.929182","volume":"198","author":"RE Garfield","year":"1977","unstructured":"Garfield RE, Sims S, Daniel EE. Gap junctions: their presence and necessity in myometrium during parturition. Science. 1977;198(4320):958\u2013960.","journal-title":"Science"},{"issue":"3","key":"23070838_CR9","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/S0006-3495(96)79332-3","volume":"71","author":"H Miyoshi","year":"1996","unstructured":"Miyoshi H, Boyle MB, MacKay LB, Garfield RE. Voltage-clamp studies of gap junctions between uterine muscle cells during term and preterm labor. Biophys J. 1996;71(3):1324\u20131334.","journal-title":"Biophys J"},{"issue":"4","key":"23070838_CR10","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1476-5381.1994.tb13201.x","volume":"112","author":"Y Kasai","year":"1994","unstructured":"Kasai Y, Iino M, Tsutsumi O, Taketani Y, Endo M. Effects of cyclopiazonic acid on rhythmic contractions in uterine smooth muscle bundles of the rat. Br J Pharmacol. 1994;112(4):1132\u20131136.","journal-title":"Br J Pharmacol"},{"issue":"3","key":"23070838_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000291842","volume":"43","author":"T Kawarabayashi","year":"1997","unstructured":"Kawarabayashi T, Shojo H, Tsukamoto T. Effects of oxytocin, prostaglandin F2 alpha and prostaglandin E2 on intracellular free calcium concentrations of longitudinal muscle cells isolated from term pregnant rat myometrium. Gynecol Obst Invest. 1997;43(3):145\u2013149.","journal-title":"Gynecol Obst Invest"},{"issue":"4","key":"23070838_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00424-003-1175-z","volume":"447","author":"H Miyoshi","year":"2004","unstructured":"Miyoshi H, Yamaoka K, Garfield RE, Ohama K. Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats. Eur J Physiol. 2004;447(4):457\u2013464.","journal-title":"Eur J Physiol"},{"issue":"4","key":"23070838_CR13","doi-asserted-by":"publisher","first-page":"r1117","DOI":"10.1152\/ajpregu.00507.2009","volume":"298","author":"H Miyoshi","year":"2010","unstructured":"Miyoshi H, Yamaoka K, Urabe S, Kodama M, Kudo Y. Functional expression of purinergic P2X7 receptors in pregnant rat myometrium. Am J Physiol Reg Integr Comp Physiol. 2010;298(4):r1117\u2013R1124.","journal-title":"Am J Physiol Reg Integr Comp Physiol"},{"issue":"12","key":"23070838_CR14","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1177\/1933719112450333","volume":"19","author":"H Miyoshi","year":"2012","unstructured":"Miyoshi H, Yamaoka K, Urabe S, Kudo Y. ATP-induced currents carried through P2X7 receptor in rat myometrial cells. Reprod Sci. 2012;19(12):1285\u20131291.","journal-title":"Reprod Sci"},{"issue":"11","key":"23070838_CR15","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.3109\/14767058.2012.697942","volume":"25","author":"EY Chang","year":"2012","unstructured":"Chang EY, Zhang J, Sullivan S, Newman R, Singh I. N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. J Mat Fetal Neonat Med. 2012;25(11):2395\u20132400.","journal-title":"J Mat Fetal Neonat Med"},{"issue":"1-2","key":"23070838_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0165-0378(97)00065-X","volume":"36","author":"DJ Dudley","year":"1997","unstructured":"Dudley DJ. Pre-term labor: an intra-uterine inflammatory response syndrome? J Reprod Immunol. 1997;36(1\u20132):93\u2013109.","journal-title":"J Reprod Immunol"},{"issue":"7","key":"23070838_CR17","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1210\/me.2009-0016","volume":"23","author":"CR Mendelson","year":"2009","unstructured":"Mendelson CR. Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mol Endocrinol. 2009;23(7):947\u2013954.","journal-title":"Mol Endocrinol"},{"issue":"12","key":"23070838_CR18","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1177\/1933719109344630","volume":"16","author":"S Urabe","year":"2009","unstructured":"Urabe S, Miyoshi H, Fujiwara H, Yamaoka K, Kudo Y. Enhanced expression of P2X4 and P2X7 purinergic receptors in the myometrium of pregnant rats in preterm delivery models. Reprod Sci. 2009;16(12):1186\u20131192.","journal-title":"Reprod Sci"},{"issue":"11","key":"23070838_CR19","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s00535-012-0738-1","volume":"48","author":"H Furusho","year":"2013","unstructured":"Furusho H, Miyauchi M, Hyogo H, et al. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. J Gastroenterol. 2013;48(11):1259\u20131270.","journal-title":"J Gastroenterol"},{"issue":"6","key":"23070838_CR20","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ejim.2010.07.011","volume":"21","author":"G Pizzo","year":"2010","unstructured":"Pizzo G, Guiglia R, Lo Russo L, Campisi G. Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept. Eur J Intern Med. 2010;21(6):496\u2013502.","journal-title":"Eur J Intern Med"},{"issue":"suppl 4","key":"23070838_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01798.x","volume":"13","author":"GJ Seymour","year":"2007","unstructured":"Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007;13(suppl 4):3\u201310.","journal-title":"Clin Microbiol Infect"},{"issue":"12","key":"23070838_CR22","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1902\/jop.2003.74.12.1764","volume":"74","author":"K Hasegawa","year":"2003","unstructured":"Hasegawa K, Shimotsu A, Nakamura M, et al. Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol. 2003;74(12):1762\u20131770.","journal-title":"J Periodontol"},{"issue":"5","key":"23070838_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/154405910208100505","volume":"81","author":"ES Davenport","year":"2002","unstructured":"Davenport ES, Williams CE, Sterne JA, Murad S, Sivapathasundram V, Curtis MA. Maternal periodontal disease and preterm low birthweight: case-control study. J Dent Res. 2002;81(5):313\u2013318.","journal-title":"J Dent Res"},{"issue":"4","key":"23070838_CR24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1600-0765.2011.01366.x","volume":"46","author":"K Hasegawa-Nakamura","year":"2011","unstructured":"Hasegawa-Nakamura K, Tateishi F, Nakamura T, et al. The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis. J Periodont Res. 2011;46(4):497\u2013504.","journal-title":"J Periodont Res"},{"issue":"10","key":"23070838_CR25","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1902\/jop.1996.67.10.1103","volume":"67","author":"S Offenbacher","year":"1996","unstructured":"Offenbacher S, Katz V, Fertik G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 1996;67(10):1103\u20131113.","journal-title":"J Periodontol"},{"issue":"8","key":"23070838_CR26","doi-asserted-by":"publisher","first-page":"e0137249","DOI":"10.1371\/journal.pone.0137249","volume":"10","author":"M Ao","year":"2015","unstructured":"Ao M, Miyauchi M, Furusho H, et al. Dental infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One. 2015;10(8):e0137249. doi:10.1371\/journal.pone.0137249.","journal-title":"PLoS One"},{"issue":"6","key":"23070838_CR27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/0022034509338032","volume":"88","author":"J Katz","year":"2009","unstructured":"Katz J, Chegini N, Shiverick KT, Lamont RJ. Localization of P. gingivalis in preterm delivery placenta. J Dent Res. 2009;88(6):575\u2013578.","journal-title":"J Dent Res"},{"issue":"3","key":"23070838_CR28","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0002-9378(89)90409-2","volume":"161","author":"R Romero","year":"1989","unstructured":"Romero R, Sirtori M, Oyarzun E, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obst Gynecol. 1989;161(3):817\u2013824.","journal-title":"Am J Obst Gynecol"},{"issue":"1","key":"23070838_CR29","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0002-9378(50)90370-X","volume":"59","author":"IC Knox Jr","year":"1950","unstructured":"Knox IC Jr, Hoerner JK. The role of infection in premature rupture of the membranes. Am J Obst Gynecol. 1950;59(1):190\u2013194, illust.","journal-title":"Am J Obst Gynecol"},{"issue":"7","key":"23070838_CR30","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1096\/fj.12-205765","volume":"26","author":"M Barbera-Cremades","year":"2012","unstructured":"Barbera-Cremades M, Baroja-Mazo A, Gomez AI, Machado F, Di Virgilio F, Pelegr\u00edn P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release. FASEB J. 2012;26(7):2951\u20132962.","journal-title":"FASEB J"},{"issue":"3","key":"23070838_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1042\/CS20120479","volume":"125","author":"CW Chiao","year":"2013","unstructured":"Chiao CW, da Silva-Santos JE, Giachini FR, Tostes RC, Su MJ, Webb RC. P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction. Clin Sci. 2013;125(3):131\u2013141.","journal-title":"Clin Sci"},{"issue":"4","key":"23070838_CR32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4103\/2319-4170.127803","volume":"37","author":"AC Morandini","year":"2014","unstructured":"Morandini AC, Savio LE, Coutinho-Silva R. The role of P2X7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases. Biomed J. 2014;37(4):169\u2013177.","journal-title":"Biomed J"},{"issue":"18","key":"23070838_CR33","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1523\/JNEUROSCI.5417-06.2007","volume":"27","author":"HB Choi","year":"2007","unstructured":"Choi HB, Ryu JK, Kim SU, McLarnon JG. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci. 2007;27(18):4957\u20134968.","journal-title":"J Neurosci"},{"key":"23070838_CR34","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/ncomms2023","volume":"3","author":"Y Kurashima","year":"2012","unstructured":"Kurashima Y, Amiya T, Nochi T, et al. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Comm. 2012;3:1034.","journal-title":"Nat Comm"},{"issue":"18","key":"23070838_CR35","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","volume":"28","author":"J Kang","year":"2008","unstructured":"Kang J, Kang N, Lovatt D, et al. Connexin 43 hemichannels are permeable to ATP. J Neurosci. 2008;28(18):4702\u20134711.","journal-title":"J Neurosci"},{"issue":"5","key":"23070838_CR36","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/0002-9378(92)91628-N","volume":"166","author":"RS Gibbs","year":"1992","unstructured":"Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obst Gynecol. 1992;166(5):1515\u20131528.","journal-title":"Am J Obst Gynecol"},{"issue":"2","key":"23070838_CR37","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0095-5108(18)30286-0","volume":"22","author":"R Gomez","year":"1995","unstructured":"Gomez R, Ghezzi F, Romero R, Mu\u00f1oz H, Tolosa JE, Rojas I. Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol. 1995;22(2):281\u2013342.","journal-title":"Clin Perinatol"},{"issue":"2","key":"23070838_CR38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.8755-8920.2000.440201.x","volume":"44","author":"X Fang","year":"2000","unstructured":"Fang X, Wong S, Mitchell BF. Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus. Am J Reprod Immunol. 2000;44(2):65\u201372.","journal-title":"Am J Reprod Immunol"},{"issue":"9","key":"23070838_CR39","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1359\/jbmr.2000.15.9.1669","volume":"15","author":"R Tonon","year":"2000","unstructured":"Tonon R, D\u2019Andrea P. Interleukin-1beta increases the functional expression of connexin 43 in articular chondrocytes: evidence for a Ca2+-dependent mechanism. J Bone Miner Res. 2000;15(9):1669\u20131677.","journal-title":"J Bone Miner Res"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115620497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719115620497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719115620497\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719115620497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719115620497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:46:48Z","timestamp":1656812808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719115620497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["23070838"],"URL":"https:\/\/doi.org\/10.1177\/1933719115620497","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"30 December 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}