{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:34:59Z","timestamp":1783352099032,"version":"3.54.6"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1177\/1933719116669057","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:07:31Z","timestamp":1474675651000},"page":"738-752","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model"],"prefix":"10.1007","volume":"24","author":[{"given":"Vaibhave","family":"Ubba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra Kumar","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangappa","family":"Chadchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet Kumar","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajender","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,30]]},"reference":[{"issue":"2","key":"24050738_CR1","first-page":"200","volume":"21","author":"EA McGee","year":"2000","unstructured":"McGee EA, Hsueh AJ. Initial and cyclic recruitment of ovarian follicles. Endocr Rev. 2000;21(2):200\u2013214.","journal-title":"Endocr Rev"},{"issue":"1","key":"24050738_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/er.2014-1020","volume":"36","author":"AJ Hsueh","year":"2015","unstructured":"Hsueh AJ, Kawamura K, Cheng Y, Fauser BC. Intraovarian control of early folliculogenesis. Endocr Rev. 2015;36(1):1\u201324.","journal-title":"Endocr Rev"},{"issue":"4","key":"24050738_CR3","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1172\/JCI41350","volume":"120","author":"JS Richards","year":"2010","unstructured":"Richards JS, Pangas SA. The ovary: basic biology and clinical implications. J Clin Invest. 2010;120(4):963\u2013972.","journal-title":"J Clin Invest"},{"issue":"1","key":"24050738_CR4","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1530\/REP-14-0499","volume":"150","author":"AS de Melo","year":"2015","unstructured":"de Melo AS, Dias SV, Cavalli RC, et al. Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause. Reproduction. 2015;150(1):R11\u2013R24.","journal-title":"Reproduction"},{"issue":"1","key":"24050738_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/humupd\/dmq032","volume":"17","author":"J Qiao","year":"2011","unstructured":"Qiao J, Feng HL. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update. 2011;17(1):17\u201333.","journal-title":"Hum Reprod Update"},{"issue":"10","key":"24050738_CR6","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","volume":"16","author":"AJ Ridley","year":"2006","unstructured":"Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol. 2006;16(10):522\u2013529.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"24050738_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/08977190600560651","volume":"24","author":"P Villalonga","year":"2006","unstructured":"Villalonga P, Ridley AJ. Rho GTPases and cell cycle control. Growth Factors. 2006;24(3):159\u2013164.","journal-title":"Growth Factors"},{"issue":"5","key":"24050738_CR8","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.ceb.2009.05.006","volume":"21","author":"A Tomar","year":"2009","unstructured":"Tomar A, Schlaepfer DD. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol. 2009;21(5):676\u2013683.","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"24050738_CR9","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4161\/cam.28721","volume":"8","author":"SM Goicoechea","year":"2014","unstructured":"Goicoechea SM, Awadia S, Garcia-Mata R. I\u2019m coming to GEF you: regulation of RhoGEFs during cell migration. Cell Adh Migr. 2014;8(6):535\u2013549.","journal-title":"Cell Adh Migr"},{"key":"24050738_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1757-2215-7-32","volume":"7","author":"VK Maurya","year":"2014","unstructured":"Maurya VK, Sangappa C, Kumar V, et al. Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse. J Ovarian Res. 2014;7:32. doi:10.1186\/1757-2215-7-32.","journal-title":"J Ovarian Res"},{"issue":"1","key":"24050738_CR11","first-page":"12","volume":"57","author":"JH Jun","year":"2016","unstructured":"Jun JH, Joo CK. MicroRNA-124 controls transforming growth factor beta1-induced epithelial-mesenchymal transition in the retinal pigment epithelium by targeting RHOG. Invest Ophthalmol Vis Sci. 2016;57(1):12\u201322.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"24050738_CR12","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1091\/mbc.E14-10-1444","volume":"26","author":"BC Jackson","year":"2015","unstructured":"Jackson BC, Ivanova IA, Dagnino L. An ELMO2-RhoG-ILK network modulates microtubule dynamics. Mol Biol Cell. 2015;26(14):2712\u20132725.","journal-title":"Mol Biol Cell"},{"issue":"11","key":"24050738_CR13","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.bbamcr.2014.07.006","volume":"1843","author":"J Lee","year":"2014","unstructured":"Lee J, Park B, Kim G, et al. Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Biochim Biophys Acta. 2014;1843(11):2438\u20132447.","journal-title":"Biochim Biophys Acta"},{"issue":"pt17","key":"24050738_CR14","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1242\/jcs.084269","volume":"124","author":"G Tzircotis","year":"2011","unstructured":"Tzircotis G, Braga VM, Caron E. RhoG is required for both FcgammaR- and CR3-mediated phagocytosis. J Cell Sci. 2011;124(pt 17):2897\u20132902.","journal-title":"J Cell Sci"},{"issue":"3","key":"24050738_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4161\/sgtp.1.3.15112","volume":"1","author":"A Morin","year":"2010","unstructured":"Morin A, Cordelieres FP, Cherfils J, Olofsson B. RhoGDI3 and RhoG: vesicular trafficking and interactions with the Sec3 Exocyst subunit. Small GTPases. 2010;1(3):142\u2013156.","journal-title":"Small GTPases"},{"issue":"20","key":"24050738_CR16","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1016\/j.yexcr.2006.09.006","volume":"312","author":"K Hiramoto","year":"2006","unstructured":"Hiramoto K, Negishi M, Katoh H. Dock4 is regulated by RhoG and promotes Rac-dependent cell migration. Exp Cell Res. 2006;312(20):4205\u20134216.","journal-title":"Exp Cell Res"},{"issue":"2","key":"24050738_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/sj.onc.1205036","volume":"21","author":"C Murga","year":"2002","unstructured":"Murga C, Zohar M, Teramoto H, Gutkind JS. Rac1 and RhoG promote cell survival by the activation of PI3 K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene. 2002;21(2):207\u2013216.","journal-title":"Oncogene"},{"key":"24050738_CR18","doi-asserted-by":"publisher","first-page":"23972","DOI":"10.1038\/srep23972","volume":"6","author":"L Zhao","year":"2016","unstructured":"Zhao L, Du X, Huang K, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016;6:23972. doi:10.1038\/srep23972.","journal-title":"Sci Rep"},{"issue":"6","key":"24050738_CR19","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1101\/gad.236349.113","volume":"28","author":"M Laurin","year":"2014","unstructured":"Laurin M, Cote JF. Insights into the biological functions of Dock family guanine nucleotide exchange factors. Genes Dev. 2014;28(6):533\u2013547.","journal-title":"Genes Dev"},{"issue":"52","key":"24050738_CR20","doi-asserted-by":"publisher","first-page":"8413","DOI":"10.1038\/sj.onc.1206888","volume":"22","author":"RV Mettus","year":"2003","unstructured":"Mettus RV, Rane SG. Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice. Oncogene. 2003;22(52):8413\u20138421.","journal-title":"Oncogene"},{"issue":"9","key":"24050738_CR21","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1007\/s10495-006-9148-2","volume":"11","author":"H Honnma","year":"2006","unstructured":"Honnma H, Endo T, Henmi H, et al. Altered expression of Fas\/Fas ligand\/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. Apoptosis. 2006;11(9):1525\u20131533.","journal-title":"Apoptosis"},{"issue":"3","key":"24050738_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/ar.1092340307","volume":"234","author":"E Anderson","year":"1992","unstructured":"Anderson E, Lee MT, Lee GY. Cystogenesis of the ovarian antral follicle of the rat: ultrastructural changes and hormonal profile following the administration of dehydroepiandrosterone. Anat Rec. 1992;234(3):359\u2013382.","journal-title":"Anat Rec"},{"issue":"3","key":"24050738_CR23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1095\/biolreprod25.3.629","volume":"25","author":"TM Kirsch","year":"1981","unstructured":"Kirsch TM, Friedman AC, Vogel RL, Flickinger GL. Macrophages in corpora lutea of mice: characterization and effects on steroid secretion. Biol Reprod. 1981;25(3):629\u2013638.","journal-title":"Biol Reprod"},{"issue":"4","key":"24050738_CR24","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1095\/biolreprod21.4.773","volume":"21","author":"KL Campbell","year":"1979","unstructured":"Campbell KL. Ovarian granulosa cells isolated with EGTA and hypertonic sucrose: cellular integrity and function. Biol Reprod. 1979;21(4):773\u2013786.","journal-title":"Biol Reprod"},{"key":"24050738_CR25","doi-asserted-by":"publisher","first-page":"18319","DOI":"10.1038\/srep18319","volume":"5","author":"MJ Chen","year":"2015","unstructured":"Chen MJ, Chou CH, Chen SU, Yang WS, Yang YS, Ho HN. The effect of androgens on ovarian follicle maturation: dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARgamma-dependent PTEN expression. Sci Rep. 2015;5:18319. doi:10.1038\/srep18319.:18319.","journal-title":"Sci Rep"},{"issue":"2","key":"24050738_CR26","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.ydbio.2006.12.011","volume":"303","author":"E Voronina","year":"2007","unstructured":"Voronina E, Lovasco LA, Gyuris A, Baumgartner RA, Parlow AF, Freiman RN. Ovarian granulosa cell survival and proliferation requires the gonad-selective TFIID subunit TAF4b. Dev Biol. 2007;303(2):715\u2013726.","journal-title":"Dev Biol"},{"issue":"6","key":"24050738_CR27","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1095\/biolreprod57.6.1509","volume":"57","author":"Z Yan","year":"1997","unstructured":"Yan Z, Lee GY, Anderson E. Influence of dehydroepiandrosterone on the expression of insulin-like growth factor-1 during cystogenesis in polycystic rat ovaries and in cultured rat granulosa cells. Biol Reprod. 1997;57(6):1509\u20131516.","journal-title":"Biol Reprod"},{"issue":"4","key":"24050738_CR28","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1095\/biolreprod56.4.891","volume":"56","author":"AJ Duleba","year":"1997","unstructured":"Duleba AJ, Spaczynski RZ, Olive DL, Behrman HR. Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells. Biol Reprod. 1997;56(4):891\u2013897.","journal-title":"Biol Reprod"},{"issue":"2","key":"24050738_CR29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0165-022X(00)00107-X","volume":"45","author":"SK Li","year":"2000","unstructured":"Li SK, Hearn MT. Isolation of thecal cells: an assessment of purity and steroidogenic potential. J Biochem Biophys Methods. 2000;45(2):169\u2013181.","journal-title":"J Biochem Biophys Methods"},{"issue":"5","key":"24050738_CR30","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1210\/endo-122-5-2345","volume":"122","author":"DA Magoffin","year":"1988","unstructured":"Magoffin DA, Erickson GF. Purification of ovarian theca-interstitial cells by density gradient centrifugation. Endocrinology. 1988;122(5):2345\u20132347.","journal-title":"Endocrinology"},{"key":"24050738_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1757-2215-7-21","volume":"7","author":"I Ortega","year":"2014","unstructured":"Ortega I, Villanueva JA, Wong DH, et al. Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. J Ovarian Res. 2014;7:21. doi:10.1186\/1757-2215-7-21.","journal-title":"J Ovarian Res"},{"key":"24050738_CR32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1477-7827-8-88","volume":"8","author":"FG Vazquez-Cuevas","year":"2010","unstructured":"Vazquez-Cuevas FG, Zarate-Diaz EP, Garay E, Arellano RO. Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells. Reprod Biol Endocrinol. 2010;8:88. doi:10.1186\/1477-7827-8-88.","journal-title":"Reprod Biol Endocrinol"},{"key":"24050738_CR33","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.mce.2016.01.014","volume":"425","author":"SB Chadchan","year":"2016","unstructured":"Chadchan SB, Kumar V, Maurya VK, Soni UK, Jha RK. Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation. Mol Cell Endocrinol. 2016;425:69\u201383.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"24050738_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1095\/biolreprod.114.122838","volume":"92","author":"V Kumar","year":"2015","unstructured":"Kumar V, Maurya VK, Joshi A, Meeran SM, Jha RK. Integrin beta 8 (ITGB8) regulates embryo implantation potentially via controlling the activity of TGF-B1 in mice. Biol Reprod. 2015;92(4):109.","journal-title":"Biol Reprod"},{"issue":"5259","key":"24050738_CR35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227(5259):680\u2013685.","journal-title":"Nature"},{"issue":"6","key":"24050738_CR36","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1530\/REP-13-0588","volume":"147","author":"A Joshi","year":"2014","unstructured":"Joshi A, Mahfooz S, Maurya VK, et al. PARP-1 during embryo implantation and its up-regulation by oestradiol in mice. Reproduction. 2014;147(6):765\u2013780.","journal-title":"Reproduction"},{"issue":"12","key":"24050738_CR37","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1007\/s11064-010-0297-x","volume":"35","author":"V Spina-Purrello","year":"2010","unstructured":"Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E. Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFgamma-induced oxidative stress. Neurochem Res. 2010;35(12):2144\u20132153.","journal-title":"Neurochem Res"},{"issue":"3","key":"24050738_CR38","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1083\/jcb.133.3.617","volume":"133","author":"AM Murphy","year":"1996","unstructured":"Murphy AM, Montell DJ. Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol. 1996;133(3):617\u2013630.","journal-title":"J Cell Biol"},{"issue":"4","key":"24050738_CR39","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00404-012-2642-6","volume":"287","author":"MB Franz","year":"2013","unstructured":"Franz MB, Daube S, Keck C, Sator M, Pietrowski D. Small GTPases are involved in sprout formation in human granulosa lutein cells. Arch Gynecol Obstet. 2013;287(4):819\u2013824.","journal-title":"Arch Gynecol Obstet"},{"issue":"6947","key":"24050738_CR40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature01817","volume":"424","author":"H Katoh","year":"2003","unstructured":"Katoh H, Negishi M. RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature. 2003;424(6947):461\u2013464.","journal-title":"Nature"},{"issue":"3","key":"24050738_CR41","doi-asserted-by":"publisher","first-page":"H448","DOI":"10.1152\/ajpheart.00773.2013","volume":"307","author":"A Sidibe","year":"2014","unstructured":"Sidibe A, Polena H, Razanajatovo J, et al. Dynamic phosphorylation of VE-cadherin Y685 throughout mouse estrous cycle in ovary and uterus. Am J Physiol Heart Circ Physiol. 2014;307(3):H448\u2013H454.","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719116669057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719116669057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719116669057\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719116669057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719116669057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:55:07Z","timestamp":1656813307000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719116669057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["24050738"],"URL":"https:\/\/doi.org\/10.1177\/1933719116669057","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"30 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}