{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:11:01Z","timestamp":1778033461786,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1177\/1933719117691140","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T13:02:44Z","timestamp":1487250164000},"page":"1503-1511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of an Antagonistic Analog of Growth Hormone-Releasing Hormone on Endometriosis in a Mouse Model and In Vitro"],"prefix":"10.1007","volume":"24","author":[{"given":"Frank","family":"K\u00f6ster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew V.","family":"Schally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Zhi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman L.","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Hornung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Marschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Rody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg B.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Finas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,30]]},"reference":[{"issue":"4","key":"24111503_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/1933719108330568","volume":"16","author":"PA Rogers","year":"2009","unstructured":"Rogers PA, D\u2019Hooghe TM, Fazleabas A, et al. Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009;16(4):335\u2013346.","journal-title":"Reprod Sci"},{"issue":"3","key":"24111503_CR2","first-page":"349","volume":"7","author":"C Mehedintu","year":"2014","unstructured":"Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7(3):349\u2013357.","journal-title":"J Med Life"},{"issue":"1","key":"24111503_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/ncpendmet0677","volume":"4","author":"AV Schally","year":"2008","unstructured":"Schally AV, Varga JL, Engel JB. Antagonists of growthhormone-releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab. 2008;4(1):33\u201343.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"6","key":"24111503_CR4","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1210\/jc.2004-2179","volume":"90","author":"JB Engel","year":"2005","unstructured":"Engel JB, Keller G, Schally AV, et al. Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone. J Clin Endocrinol Metab. 2005;90(6):3614\u20133621.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"24111503_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.canlet.2010.05.022","volume":"298","author":"HM Wu","year":"2010","unstructured":"Wu HM, Schally AV, Cheng JC, Zarandi M, Varga J, Leung PC. Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCd-mediated activation of p53\/p21. Cancer Lett. 2010;298(1):16\u201325.","journal-title":"Cancer Lett"},{"key":"24111503_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0083-6729(05)70001-7","volume":"70","author":"H Kiaris","year":"2005","unstructured":"Kiaris H, Schally AV, Kalofoutis A. Extrapituitary effects of the growth hormone-releasing hormone. Vitam Horm. 2005;70:1\u201324.","journal-title":"Vitam Horm"},{"issue":"1","key":"24111503_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.fertnstert.2008.04.048","volume":"92","author":"L Fu","year":"2009","unstructured":"Fu L, Osuga Y, Yano T, et al. Expression and possible implication of growth hormone-releasing hormone receptor splice variant 1 in endometriosis. Fertil Steril. 2009;92(1):47\u201353.","journal-title":"Fertil Steril"},{"issue":"3","key":"24111503_CR8","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.fertnstert.2009.03.093","volume":"94","author":"M Annunziata","year":"2010","unstructured":"Annunziata M, Grande C, Scarlatti F, et al. The growth hormonereleasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line. Fertil Steril. 2010;94(3):841\u2013849.","journal-title":"Fertil Steril"},{"issue":"4","key":"24111503_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.2174\/092986708783497355","volume":"15","author":"M Kovacs","year":"2008","unstructured":"Kovacs M, Schally AV, Varga JL, Zarandi M. Endocrine and antineoplastic actions of growth hormone-releasing hormone antagonists. Curr Med Chem. 2008;15(4):314\u2013321.","journal-title":"Curr Med Chem"},{"issue":"10","key":"24111503_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.18632\/oncoscience.92","volume":"1","author":"R Perez","year":"2014","unstructured":"Perez R, Schally AV, Popovics P, et al. Antagonistic analogs of growth hormone-releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; a preclinical study. Oncoscience. 2014;1(10):665\u2013673.","journal-title":"Oncoscience"},{"issue":"2","key":"24111503_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10549-008-0120-4","volume":"116","author":"F Koster","year":"2009","unstructured":"Koster F, Engel JB, Schally AV, et al. Triple-negative breast cancers express receptors for growth hormone-releasing hormone (GHRH) and respond to GHRH antagonists with growth inhibition. Breast Cancer Res Treat. 2009;116(2):273\u2013279.","journal-title":"Breast Cancer Res Treat"},{"key":"24111503_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1477-7827-8-54","volume":"8","author":"J Guo","year":"2010","unstructured":"Guo J, Schally AV, Zarandi M, Varga J, Leung PC. Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. Reprod Biol Endocrinol. 2010;8:54.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"24111503_CR13","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.fertnstert.2007.07.1358","volume":"90","author":"SK Banu","year":"2008","unstructured":"Banu SK, Lee J, Starzinski-Powitz A, Arosh JA. Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells. Fertil Steril. 2008;90(4):972\u2013987.","journal-title":"Fertil Steril"},{"issue":"9","key":"24111503_CR14","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","volume":"30","author":"MW Pfaffl","year":"2002","unstructured":"Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002;30(9): e36.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"24111503_CR15","first-page":"1025","volume":"39","author":"E Pozsgai","year":"2011","unstructured":"Pozsgai E, Schally AV, Hocsak E, Zarandi M, Rick F, Bellyei S. The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines. Int J Oncol. 2011;39(4):1025\u20131032.","journal-title":"Int J Oncol"},{"issue":"10","key":"24111503_CR16","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1002\/ijc.25259","volume":"127","author":"E Pozsgai","year":"2010","unstructured":"Pozsgai E, Schally AV, Zarandi M, Varga JL, Vidaurre I, Bellyei S. The effect of GHRH antagonists on human glioblastomas and their mechanism of action. Int J Cancer. 2010;127(10):2313\u20132322.","journal-title":"Int J Cancer"},{"issue":"1","key":"24111503_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.canlet.2009.12.014","volume":"293","author":"S Bellyei","year":"2010","unstructured":"Bellyei S, Schally AV, Zarandi M, Varga JL, Vidaurre I, Pozsgai E. GHRH antagonists reduce the invasive and metastatic potential of human cancer cell lines in vitro. Cancer Lett. 2010;293(1):31\u201340.","journal-title":"Cancer Lett"},{"issue":"17","key":"24111503_CR18","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.4161\/15384101.2015.945879","volume":"13","author":"L Szalontay","year":"2014","unstructured":"Szalontay L, Schally AV, Popovics P, et al. Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function. Cell Cycle. 2014;13(17):2790\u20132797.","journal-title":"Cell Cycle"},{"issue":"3","key":"24111503_CR19","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1073\/pnas.1323102111","volume":"111","author":"CD Fahrenholtz","year":"2014","unstructured":"Fahrenholtz CD, Rick FG, Garcia MI, et al. Preclinical efficacy of growth hormone-releasing hormone antagonists for androgendependent and castration-resistant human prostate cancer. Proc Natl Acad Sci U S A. 2014;111(3):1084\u20131089.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"24111503_CR20","doi-asserted-by":"publisher","first-page":"988","DOI":"10.18632\/oncotarget.634","volume":"3","author":"R Perez","year":"2012","unstructured":"Perez R, Schally AV, Vidaurre I, Rincon R, Block NL, Rick FG. Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers. Oncotarget. 2012;3(9):988\u2013997.","journal-title":"Oncotarget"},{"issue":"3","key":"24111503_CR21","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/cncr.26291","volume":"118","author":"A Klukovits","year":"2012","unstructured":"Klukovits A, Schally AV, Szalontay L, et al. Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers. Cancer. 2012;118(3):670\u2013680.","journal-title":"Cancer"},{"issue":"13","key":"24111503_CR22","doi-asserted-by":"publisher","first-page":"5575","DOI":"10.1073\/pnas.0700407104","volume":"104","author":"N Barabutis","year":"2007","unstructured":"Barabutis N, Tsellou E, Schally AV, Kouloheri S, Kalofoutis A, Kiaris H. Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormonereleasing hormone receptor. Proc Natl Acad Sci U S A. 2007;104(13):5575\u20135579.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"24111503_CR23","first-page":"33","volume":"7","author":"Q Wang","year":"2013","unstructured":"Wang Q, Wang Y, Fu X, Huang Y. Comparison of expression of growth hormone-releasing hormone and its receptor splice variant 1 in different stages of endometriosis. Int J Fertil Steril. 2013;7(1):33\u201338.","journal-title":"Int J Fertil Steril"},{"issue":"8","key":"24111503_CR24","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1634\/stemcells.2006-0828","volume":"25","author":"H Du","year":"2007","unstructured":"Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25(8):2082\u20132086.","journal-title":"Stem Cells"},{"issue":"1","key":"24111503_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S0015-0282(00)01658-7","volume":"75","author":"O Khorram","year":"2001","unstructured":"Khorram O, Garthwaite M, Grosen E, Golos T. Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions. Fertil Steril. 2001;75(1):174\u2013179.","journal-title":"Fertil Steril"},{"issue":"12","key":"24111503_CR26","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1172\/JCI119478","volume":"99","author":"KL Bruner","year":"1997","unstructured":"Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest. 1997;99(12):2851\u20132857.","journal-title":"J Clin Invest"},{"issue":"3","key":"24111503_CR27","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/humrep\/15.3.572","volume":"15","author":"M Nisolle","year":"2000","unstructured":"Nisolle M, Casanas-Roux F, Marbaix E, Jadoul P, Donnez J. Transplantation of cultured explants of human endometrium into nude mice. Hum Reprod. 2000;15(3):572\u2013577.","journal-title":"Hum Reprod"},{"issue":"2","key":"24111503_CR28","first-page":"337","volume":"121","author":"A Bergqvist","year":"1985","unstructured":"Bergqvist A, Jeppsson S, Kullander S, Ljungberg O. Human uterine endometrium and endometriotic tissue transplanted into nude mice. Morphologic effects of various steroid hormones. Am J Pathol. 1985;121(2):337\u2013341.","journal-title":"Am J Pathol"},{"issue":"6","key":"24111503_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.2174\/1566524013363168","volume":"1","author":"A Starzinski-Powitz","year":"2001","unstructured":"Starzinski-Powitz A, Zeitvogel A, Schreiner A, Baumann R. In search of pathogenic mechanisms in endometriosis: the challenge for molecular cell biology. Curr Mol Med. 2001;1(6):655\u2013664.","journal-title":"Curr Mol Med"},{"issue":"3","key":"24111503_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/1933719110386241","volume":"18","author":"L Aghajanova","year":"2011","unstructured":"Aghajanova L, Giudice LC. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reprod Sci. 2011;18(3):229\u2013251.","journal-title":"Reprod Sci"},{"issue":"9","key":"24111503_CR31","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1210\/me.2005-0001","volume":"20","author":"G Siriwardana","year":"2006","unstructured":"Siriwardana G, Bradford A, Coy D, Zeitler P. Autocrine\/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endocrinol. 2006;20(9):2010\u20132019.","journal-title":"Mol Endocrinol"},{"issue":"1","key":"24111503_CR32","doi-asserted-by":"publisher","first-page":"E224","DOI":"10.1152\/ajpendo.00050.2003","volume":"285","author":"AS Khan","year":"2003","unstructured":"Khan AS, Fiorotto ML, Cummings KK, Pope MA, Brown PA, Draghia-Akli R. Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs. Am J Physiol Endocrinol Metab. 2003;285(1): E224\u2013E231.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"24111503_CR33","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1089\/dna.2006.25.429","volume":"25","author":"ML Fiorotto","year":"2006","unstructured":"Fiorotto ML, Lopez R, Oliver WT, Khan AS, Draghia-Akli R. Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. DNA Cell Biol. 2006;25(8):429\u2013437.","journal-title":"DNA Cell Biol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719117691140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719117691140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719117691140\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719117691140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719117691140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T02:00:10Z","timestamp":1656813610000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719117691140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["24111503"],"URL":"https:\/\/doi.org\/10.1177\/1933719117691140","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"30 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}