{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:38:28Z","timestamp":1792201108514,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1177\/1933719117699706","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T11:54:19Z","timestamp":1491306859000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women"],"prefix":"10.1007","volume":"25","author":[{"given":"Yinan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahn Rhi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"issue":"3","key":"2501044_CR1","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/S0002-9378(94)70284-5","volume":"170","author":"L Chow","year":"1994","unstructured":"Chow L, Lye SJ. Expression of the gap junction protein connexin-43 is increased in the human myometrium toward term and with the onset of labor. Am J Obstet Gynecol. 1994;170(3):788\u2013795.","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"2501044_CR2","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/molehr\/5.9.880","volume":"5","author":"DM Slater","year":"1999","unstructured":"Slater DM, Dennes WJ, Campa JS, Poston L, Bennett PR. Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy. Mol Hum Reprod. 1999;5(9):880\u2013884.","journal-title":"Mol Hum Reprod"},{"issue":"pt24","key":"2501044_CR3","doi-asserted-by":"publisher","first-page":"6063","DOI":"10.1113\/jphysiol.2008.164004","volume":"586","author":"P Arthur","year":"2008","unstructured":"Arthur P, Taggart MJ, Zielnik B, Wong S, Mitchell BF. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J Physiol. 2008;586(pt 24):6063\u20136076.","journal-title":"J Physiol"},{"issue":"6","key":"2501044_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/jne.12154","volume":"26","author":"S Arrowsmith","year":"2014","unstructured":"Arrowsmith S, Wray S. Oxytocin: its mechanism of action and receptor signalling in the myometrium. J Neuroendocrinol. 2014;26(6):356\u2013369.","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"2501044_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.plefa.2003.04.004","volume":"70","author":"L Myatt","year":"2004","unstructured":"Myatt L, Lye SJ. Expression, localization and function of prostaglandin receptors in myometrium. Prostaglandins Leukot Essent Fatty Acids. 2004;70(2):137\u2013148.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"4","key":"2501044_CR6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2826.2008.01668.x","volume":"20","author":"NM Orsi","year":"2008","unstructured":"Orsi NM, Tribe RM. Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol. 2008;20(4):462\u2013469.","journal-title":"J Neuroendocrinol"},{"issue":"5","key":"2501044_CR7","first-page":"514","volume":"21","author":"JRG Challis","year":"2000","unstructured":"Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000;21(5):514\u2013550.","journal-title":"Endocr Rev"},{"issue":"5","key":"2501044_CR8","first-page":"1705","volume":"84","author":"C Sparey","year":"1999","unstructured":"Sparey C, Robson SC, Bailey J, Lyall F, Europe-Finner GN. The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and Gs alpha proteins in the upper and lower segments of the human uterus during pregnancy and labor. J Clin Endocrinol Metab. 1999;84(5):1705\u20131710.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2501044_CR9","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1210\/jc.2002-021212","volume":"88","author":"AM Blanks","year":"2003","unstructured":"Blanks AM, Vatish M, Allen MJ, et al. Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. J Clin Endocrinol Metab. 2003;88(7):3392\u20133400.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2501044_CR10","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/molehr\/gal061","volume":"12","author":"SR Sooranna","year":"2006","unstructured":"Sooranna SR, Grigsby PL, Engineer N, et al. Myometrial prostaglandin E2 synthetic enzyme mRNA expression: spatial and temporal variations with pregnancy and labour. Mol Hum Reprod. 2006;12(10):625\u2013631.","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"2501044_CR11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/molehr\/gah158","volume":"11","author":"S Astle","year":"2005","unstructured":"Astle S, Thornton S, Slater DM. Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy. Mol Hum Reprod. 2005;11(4):279\u2013287.","journal-title":"Mol Hum Reprod"},{"issue":"12","key":"2501044_CR12","doi-asserted-by":"publisher","first-page":"E1512","DOI":"10.1210\/jc.2015-2815","volume":"100","author":"L Liu","year":"2015","unstructured":"Liu L, Li H, Dargahi D, et al. HoxA13 regulates phenotype regionalization of human pregnant myometrium. J Clin Endocrinol Metab. 2015;100(12):E1512\u2013E1522.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2501044_CR13","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1210\/en.2015-2005","volume":"157","author":"H Li","year":"2016","unstructured":"Li H, Yu Y, Shi Y, et al. HoxA13 stimulates myometrial cells to secrete IL-1b and enhance the expression of contraction associated genes (accepted). Endocrinology. 2016;157(5):2129\u20132139.","journal-title":"Endocrinology"},{"issue":"1","key":"2501044_CR14","first-page":"23","volume":"75","author":"TR Lappin","year":"2006","unstructured":"Lappin TR, Grier DG, Thompson A, Halliday HL. HOX genes: seductive science, mysterious mechanisms. Ulster Med J. 2006;75(1):23\u201331.","journal-title":"Ulster Med J"},{"issue":"7","key":"2501044_CR15","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI1597","volume":"101","author":"HS Taylor","year":"1998","unstructured":"Taylor HS, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101(7):1379\u20131384.","journal-title":"J Clin Invest"},{"issue":"suppl1","key":"2501044_CR16","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1186\/1471-2393-13-S1-S7","volume":"13","author":"AA Mosher","year":"2013","unstructured":"Mosher AA, Rainey KJ, Bolstad SS, et al. Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy Childbirth. 2013; 13(suppl 1):S7.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"7","key":"2501044_CR17","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1210\/jc.2012-4000","volume":"98","author":"Y Yu","year":"2013","unstructured":"Yu Y, Liu L, Xie N, et al. Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control. J Clin Endocrinol Metab. 2013;98(7):2887\u20132896.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2501044_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1095\/biolreprod.112.100099","volume":"87","author":"AA Mosher","year":"2012","unstructured":"Mosher AA, Rainey KJ, Giembycz MA, Wood S, Slater DM. Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors. Biol Reprod. 2012;87(1):7, 1\u201310.","journal-title":"Biol Reprod"},{"issue":"1","key":"2501044_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1210\/jc.2012-2451","volume":"98","author":"L Liu","year":"2013","unstructured":"Liu L, Li Y, Xie N, et al. Proliferative action of the androgen receptor in human uterine myometrial cells\u2013a key regulator for myometrium phenotype programming. J Clin Endocrinol Metab. 2013;98(1):218\u2013227.","journal-title":"J Clin Endocrinol Metab"},{"key":"2501044_CR20","doi-asserted-by":"publisher","first-page":"e1338","DOI":"10.1038\/cddis.2014.303","volume":"5","author":"H Li","year":"2014","unstructured":"Li H, Li Y, Morin D, Plymate S, Lye S, Dong X. The androgen receptor mediates antiapoptotic function in myometrial cells. Cell Death Dis. 2014;5:e1338.","journal-title":"Cell Death Dis"},{"issue":"1","key":"2501044_CR21","doi-asserted-by":"publisher","first-page":"a023002","DOI":"10.1101\/cshperspect.a023002","volume":"6","author":"H Du","year":"2015","unstructured":"Du H, Taylor HS. The role of Hox genes in female reproductive tract development, adult function, and fertility. Cold Spring Harb Perspect Med. 2015;6(1):a023002.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"16","key":"2501044_CR22","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1242\/dev.128.16.3197","volume":"128","author":"Y Zhao","year":"2001","unstructured":"Zhao Y, Potter SS. Functional specificity of the HoxA13 homeo-box. Development. 2001;128(16):3197\u20133207.","journal-title":"Development"},{"issue":"6","key":"2501044_CR23","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1095\/biolreprod57.6.1338","volume":"57","author":"H V Taylor","year":"1997","unstructured":"Taylor HS, Vanden Heuvel GB, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod. 1997;57(6):1338\u20131345.","journal-title":"Biol Reprod"},{"issue":"1","key":"2501044_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1055\/s-2000-13478","volume":"18","author":"HS Taylor","year":"2000","unstructured":"Taylor HS. The role of HOX genes in the development and function of the female reproductive tract. Semin Reprod Med. 2000;18(1):81\u201389.","journal-title":"Semin Reprod Med"},{"key":"2501044_CR25","doi-asserted-by":"publisher","first-page":"11565","DOI":"10.1038\/ncomms11565","volume":"7","author":"L Nadeem","year":"2016","unstructured":"Nadeem L, Shynlova O, Matysiak-Zablocki E, Mesiano S, Dong X, Lye S. Molecular evidence of functional progesterone withdrawal in human myometrium. Nat Commun. 2016;7:11565.","journal-title":"Nat Commun"},{"issue":"5","key":"2501044_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1177\/107155760200900508","volume":"9","author":"F Lyall","year":"2002","unstructured":"Lyall F, Lye S, Teoh T, Cousins F, Milligan G, Robson S. Expression of Gsalpha, connexin-43, connexin-26, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gsalpha. J Soc Gynecol Investig. 2002;9(5):299\u2013307.","journal-title":"J Soc Gynecol Investig"},{"issue":"9","key":"2501044_CR27","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/jcmm.12307","volume":"18","author":"O Shynlova","year":"2014","unstructured":"Shynlova O, Dorogin A, Li Y, Lye S. Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice. J Cell Mol Med. 2014;18(9):1816\u20131829.","journal-title":"J Cell Mol Med"},{"issue":"2","key":"2501044_CR28","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s003350010029","volume":"11","author":"DP Mortlock","year":"2000","unstructured":"Mortlock DP, Sateesh P, Innis JW. Evolution of N-terminal sequences of the vertebrate HOXA13 protein. Mamm Genome. 2000;11(2):151\u2013158.","journal-title":"Mamm Genome"},{"issue":"pt12","key":"2501044_CR29","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1242\/jcs.02399","volume":"118","author":"KA Mace","year":"2005","unstructured":"Mace KA, Hansen SL, Myers C, Young DM, Boudreau N. HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair. J Cell Sci. 2005; 118(pt 12):2567\u20132577.","journal-title":"J Cell Sci"},{"issue":"6","key":"2501044_CR30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.4161\/cam.22164","volume":"6","author":"S Kachgal","year":"2012","unstructured":"Kachgal S, Mace KA, Boudreau NJ. The dual roles of homeobox genes in vascularization and wound healing. Cell Adh Migr. 2012;6(6):457\u2013470.","journal-title":"Cell Adh Migr"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719117699706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719117699706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719117699706\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719117699706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719117699706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T02:00:34Z","timestamp":1656813634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719117699706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2501044"],"URL":"https:\/\/doi.org\/10.1177\/1933719117699706","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"1 January 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}